HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
Bethanidine (Batel)
A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.
Also Known As:
Batel
;
Betanidine
;
Bethanidine Sulfate
; Bethanidine, Sulfate (2:1); Sulfate, Bethanidine; Guanidine, N,N'-dimethyl-N''-(phenylmethyl)-
Networked:
45
relevant articles (
3
outcomes,
10
trials/studies)
Relationship Network
Drug Context: Research Results
Organic Chemicals: 133
Amidines: 14
Guanidines: 29
Bethanidine: 45
Experts
1.
Minuchehr, Zarrin
: 1 article (03/2022)
2.
Sabouni, Farzaneh
: 1 article (03/2022)
3.
Taghvaei, Somayye
: 1 article (03/2022)
Related Diseases
1.
Ventricular Tachycardia
09/01/1985 - "
In conclusion, the efficacy of bethanidine for preventing ventricular tachyarrhythmias as assessed by programmed stimulation is low.
"
11/01/1984 - "
Ventricular tachycardia or fibrillation, inducible in all patients during the control study, could still be initiated by ventricular stimulation in 9 of 10 patients after bethanidine.
"
07/01/1986 - "
Bethanidine sulfate in paroxysmal ventricular tachycardia: toxicity and antifibrillatory actions.
"
09/01/1985 - "
Bethanidine sulfate: efficacy in prevention of ventricular tachyarrhythmias during programmed stimulation.
"
11/01/1984 - "
Acute electrophysiologic effects of bethanidine sulfate in patients with ventricular tachycardia or fibrillation.
"
2.
Hypertension (High Blood Pressure)
12/01/1968 - "
Treatment of hypertension with bethanidine (esbatal).
"
01/13/1968 - "
Bethanidine in hypertension.
"
12/02/1967 - "
Clinical experience with bethanidine in treatment of hypertension.
"
11/01/1966 - "
[The use of bethanidine sulfate (Esbatal) in hypertension].
"
01/08/1966 - "
A clinical trial of bethanidine sulphate in severe hypertension.
"
3.
Ventricular Fibrillation
08/01/1984 - "
These studies show that bethanidine is effective in preventing VT induction and, thus, its use may not be restricted only to cases of primary ventricular fibrillation.
"
09/01/1985 - "
Patients presenting with only ventricular fibrillation may have a more favorable response to bethanidine sulfate.
"
01/01/1982 - "
The oral efficacy and rapid onset of action gives bethanidine a potential role in the prevention of out-of-hospital ventricular fibrillation.
"
01/01/1982 - "
In the infarcted heart, bethanidine increased ventricular fibrillation threshold from an average postinfarction level of 14.4 mA to an average peak value of 55.3 mA, an increase of 327 percent.
"
01/01/1982 - "
Bethanidine increased ventricular fibrillation threshold in the normal dog heart from an average control value of 28.5 mA to an average peak value of 66.5 mA, an increase of 150 percent.
"
4.
Tachycardia (Tachyarrhythmias)
05/01/1984 - "
Bethanidine, in doses of 4, 8, and 16 mg/kg, slowed the cycle length of the tachycardia and allowed slower rates of ventricular pacing to produce equivalent delays at epicardial sites in the ischemic zone.
"
09/03/1976 - "
5. Bethanidine blocked the tachycardia and vasoconstriction seen in response to LBNP in control and 6-OHDA-treated rabbits.
"
04/01/1990 - "
The atrial arrhythmias were consistently terminated by procainamide and WY-48986 whereas bethanidine converted the tachycardias in one of the five dogs studied.
"
11/01/1986 - "
In studies of ouabain-induced tachycardias and 24-h infarct-induced ventricular arrhythmias, bethanidine tends to increase heart rate and/or exacerbate the ectopic activity (due to its sympathomimetic effects), whereas meobentine tends to reduce heart rate and restore normal sinus rhythm.
"
03/01/1971 - "
The tachycardia was abolished and the pressor response greatly reduced by vagotomy or atropine (250 mug/kg i.v.).4. The pressor response which remained after vagotomy was abolished by subsequent sympathetic blockade with bethanidine (2-3 mg/kg i.v.) or bretylium (10 mg/kg i.v.).5. In contrast to the effects of propranolol or cervical cord section bethanidine (4-5 mg/kg i.v.) or bretylium (10 mg/kg i.v.) significantly reduced blood pressure and heart rate responses to intravertebral prostaglandin F(2alpha).
"
5.
Hypotension (Low Blood Pressure)
09/01/1985 - "
Despite protriptyline administration in 54 of 59 bethanidine trials, symptomatic hypotension occurred in 30 trials (51%).
"
12/01/1976 - "
2. Unlike bethanidine, propranolol did not produce postural and exercise hypotension; methyldopa was intermediate in effect.
"
10/01/1975 - "
Symptoms due to orthostatic and exertional hypotension occurred in 23-4 per cent of 448 hypertensive patients treated with guanethidine, debrisoquine, or bethanidine.
"
Related Drugs and Biologics
1.
Guanethidine
2.
Procainamide (Procan)
3.
Debrisoquin (Debrisoquine)
4.
bretylium
5.
Bethanidine (Batel)
6.
meobentine
7.
Protriptyline (Vivactil)
8.
Sympathomimetics (Sympathomimetic Amines)
9.
Sotalol (Sotalol Hydrochloride)
10.
Oxprenolol (Trasicor)
Related Therapies and Procedures
1.
Therapeutics
2.
Oral Administration
3.
Vagotomy
4.
Lower Body Negative Pressure