Arcus Senilis

10/01/1979 - "The results of blood-lipid screening of 200 39--49-year-old participants with incidentally diagnosed corneal arcus from the Copenhagen City Heart Study are reported. "
09/01/1977 - "These results, together with the findings of our study, show that one ought to examine the blood-lipids, if by chance of the first refraction a fully developed arcus corneae is found."
12/01/1974 - "Studies on the pathogenesis of corneal arcus formation II. Immunofluorescent studies on lipid deposition in the eye of the lipid-fed rabbit."
03/01/1972 - "Earlier studies related the presence and severity of a corneal arcus to plasma lipid levels and linked it with certain familial hyperlipidaemias. "
01/01/2022 - "To evaluate corneal densitometry (CD) of patients with arcus senilis (AS) and its association with the serum lipid markers. "

09/15/2016 - "This outcome did not exclude the predictive role of other risk factors, such as age, cigarettes, arm circumference (protective), systolic blood pressure, vital capacity (protective), cholesterol, corneal arcus and diabetes, documented by the Cox model, that had common roles for both end-points. "
01/01/2016 - "Decreased cholesterol efflux capacity was associated with the presence of corneal arcus after adjusting for age and sex. "
10/01/2010 - "The presence of corneal arcus was significantly associated with age (P = 0.03) and high levels of total cholesterol (over 200 mg/dl, P < 0.01). "
10/01/2005 - "The multivariate hazard ratio for 5 years of age was 1.59 (CI 1.43-1.77); for heavy job-related physical activity it was 0.96 (CI 0.79-1.18); for 10 cigarettes smoked per day 1.16 (CI 1.05-1.28); for 20 mm Hg of systolic blood pressure 1.38 (CI 1.25-1.52); for 1 mmol/l of serum cholesterol 1.19 (CI 1.09-1.30); for 0.25 l/m2 of height of vital capacity 0.87 (CI 0.78-0.97); for the presence of corneal arcus 1.36 (CI 1.03-1.79). "
02/01/2004 - "Corneal arcus was significantly associated with progressively higher levels of total cholesterol over 5 mmol/l. "

09/01/2019 - "Although the arcus corneae (AC) has long been used as an age indicator for forensic purposes, its diagnostic value has not been evaluated. "
01/01/2009 - "Corneal arcus: an indicator of severe coronary artery disease in a young adult man."
03/10/2008 - "Corneal arcus is not as good an indicator of calcific atherosclerosis as Achilles tendon thickness, but its presence suggests increased atherosclerosis in these hypercholesterolemic patients."
10/01/1999 - "Corneal arcus: indicator for severity of coronary atherosclerosis?"
12/01/1998 - "Accelerated development of corneal arcus with age is an indicator of HFH, but premature arcus is not an additional marker of premature coronary disease for individual cases of HFH."

06/01/2002 - "No association between corneal arcus and fasting plasma glucose was found in all ages and both sexes. "
08/31/2022 - "Although various studies have reported a significant relationship between corneal arcus with blood lipid and glucose levels as well as blood pressure, these relationships were not found in the present study."
06/01/2002 - "The presence of corneal arcus was determined by hand-held slitlamp, serum lipids and serum plasma glucose collected on the same day as corneal arcus detection. "
01/01/1986 - "There was no consistent univariate association of xanthelasma and corneal arcus with smoking, alcohol consumption, blood pressure, obesity, sedentary lifestyle, family history of ischemic heart disease, or glucose and uric acid plasma concentrations. "
10/01/2010 - "After adjustment for age, gender, total cholesterol, serum glucose, and current smoking, many cardiovascular risk factors significantly associated with corneal arcus, including male gender (odds ratio [OR] 1.65, 95% confidence interval [CI] 1.27-2.03), older age (per 10 years, OR 4.49, 95% CI 3.91-5.15), higher body mass index (per kg/m(2), OR 1.02, 95% CI 1.00-1.04), higher levels of CRP (per 10 mg/L, OR 1.36, 95% CI 1.13-1.64), total cholesterol (per mmol/L, OR 1.21, 95% CI 1.11-1.32), low-density lipoprotein cholesterol (per mmol/L, OR 1.94, 95% CI 1.38-2.74), presence of peripheral artery disease (OR 3.85, 95% CI 1.29-11.5), chronic kidney disease (OR 1.14, 95% CI 1.03-1.38), and current smoking (OR 1.29, 95% CI 1.02-1.69). "

07/01/1985 - "This study demonstrates that arcus senilis does not have a higher prevalence rate in diabetics than non-diabetics in spite of the increased cardiovascular risk in insulin-dependent diabetics."
07/01/1985 - "The prevalence of corneal arcus senilis in known insulin-dependent diabetic patients."

01/01/2018 - "Finally, simple regression analysis showed a correlation of IMT with LDL cholesterol >190 mg/dL and corneal arcus (p < 0.01 and p < 0.001, respectively). "
03/01/1993 - "Old age and high LDL cholesterol concentration were associated with the presence of corneal arcus. "
06/01/1992 - "It is concluded that while corneal arcus is primarily an age-related change, its formation is accelerated by high serum LDL-cholesterol so that in people under 50 years it is a marker for the condition."
02/01/2002 - "These included increased cholesterol concentrations, in particular of LDL-cholesterol, in combination with the presence of tendon xanthoma, corneal arcus, xanthelasmata and a history of early CAD. "
01/01/2018 - "Familial hypercholesterolemia (FH) is a common inherited disease that exhibits significantly increased levels of low-density lipoprotein cholesterol (LDL-C), skin or tendon xanthomas, corneal arcus and premature coronary heart disease (CHD). "

04/27/2023 - "In case 2, the patient had an LDL-c level of 5.7 mmol/L and premature corneal arcus. "
10/01/2009 - "In addition to serum LDL-C, male gender and serum non-HDL-C level are significantly correlated to corneal arcus. "
07/01/2004 - "The mean LDL-C : HDL-C ratio in the group without arcus was 4.28 (SD: 1.99), and 5.73 (SD: 2.09) in the group with a corneal arcus (p < 0.05). "
04/01/2017 - "Diagnosis of FH usually depends on family history, clinical history of premature CAD, physical findings of xanthoma or corneal arcus and high levels of LDL-C. "
01/01/2017 - "After multivariable analysis, LDL-C as a continuous variable, tendon xanthomas and corneal arcus were independently associated with the presence of FH mutations. "

07/01/2004 - "The mean serum HDL-cholesterol (HDL-C) in the group with corneal arcus was 1.04 +/- 0.30 mmol/l as opposed to 1.31 +/- 0.38 mmol/l in the group without arcus (p < 0.005 for difference). "
12/01/1992 - "Although their serum HDL cholesterol levels were remarkably high, ranging from 2.67 to 3.58 mmol/L, three patients had CHD and corneal arcus was present in seven patients. "
07/25/1991 - "A proband with plasma apoA-I and HDL cholesterol that are below 15% of normal levels and with marked bilateral arcus senilis was shown to be heterozygous for a 45-base pair deletion in exon four of the apoA-I gene. "
10/01/1990 - "After excluding those with clinically manifest CHD at baseline, corneal arcus was strongly associated with CHD and CVD mortality only in hyperlipidemic men ages 30-49 years, for whom the relative risk for CHD and CVD death was 3.7 and 4.0, respectively, after adjusting for age, total cholesterol, HDL cholesterol, and smoking status using a Cox proportional hazards model. "
01/01/2009 - "Independently of total cholesterol, serum high-density lipoprotein cholesterol and smoking, corneal arcus has been suggested as a predictor of coronary heart disease among hyperlipidemic men. "

01/01/2022 - "The serum triglyceride level should give an insight into the intensity of arcus senilis. "
07/01/2004 - "Total serum cholesterol and triglyceride levels were not associated with corneal arcus. "
07/01/1977 - "[Serum cholesterol-triglycerides and their relation to age, skinfold, arcus senilis, blood pressure and electrocardiogram, in the population of homes for the aged (author's transl)]."
01/01/2021 - "Prevalence estimates were computed, and multivariable logistic regression analysis was applied to determine associated factors for corneal arcus including sex, age, spherical equivalent, central corneal thickness, intraocular pressure (IOP), socio-economic status, smoking, BMI, systolic and diastolic arterial blood pressure, HbA1c, HDL-C, LDL-C, triglyceride, and lipid modifying agents. "
04/01/2015 - "The corneal arcus consists of cholesterol, phospholipids and triglycerides. "

07/01/2004 - "To determine whether an association exists between plasma lipoprotein constituents and the prevalence of corneal arcus in dyslipidaemic patients. "
01/01/2003 - "During 2002 in ophthalmology cabinet in Dom zdravlja Fojnica, 32 patients, aged 54-56, with diagnosis arcus corneae were treated, which means that findings of lipoprotein fractions in serum has been made. "
01/01/1986 - "Thus the clinical findings of xanthelasma or corneal arcus, especially in young people, seem to identify persons with plasma lipoprotein abnormalities."
01/01/1980 - "[Lipid and lipoprotein anomalies associated with arcus senilis]."
10/17/1964 - "3. CORNEAL ARCUS: INCIDENCE AND RELATION TO SERUM LIPIDS AND LIPOPROTEINS."

12/01/2018 - "Slit lamp examination revealed the same lesions in our three patients: an early-onset corneal arcus senilis, central corneal deposits, and a gray stromal haze in the two oldest subjects. "
11/01/2011 - "Corneal arcus was detected using a standardized slit-lamp examination. "
10/01/2010 - "Corneal arcus was defined from anterior segment images taken with a slit-lamp camera. "
10/01/2009 - "Corneal arcus identification was completed by a single ophthalmologist using slit-lamp biomicroscopy examination. "
05/01/2005 - "Slit-lamp characteristics of the donor corneas showed little variation with donor age, except for the presence of corneal arcus. "

08/01/2007 - "Also, because corneal arcus represents physical evidence of early lipid deposition, its presence suggests the need for aggressive lipid therapy."

09/16/2017 - "An 85-year-old man with apparent cornea arcus senilis underwent femtosecond laser-assisted cataract surgery in his right eye. "

06/01/1966 - "Significance of arcus senilis under anesthesia."