First Generation Cephalosporins

CEPHALOSPORIN agents with excellent coverage against gram-positive cocci, such as STAPHYLOCOCCUS and STREPTOCOCCUS. They have some activity against the gram-negative bacteria, but in general, gram-negative activity is decreased compared to 2nd, 3rd, and 4th generation cephalosporins.

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Networked: 176 relevant articles (7 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hendrix, Diane V H: 2 articles (11/2021 - 01/2006)
2.	Pichichero, Michael E: 2 articles (03/2007 - 03/2007)
3.	Bollam, Neha: 1 article (09/2022)
4.	Chavez, Miguel A: 1 article (09/2022)
5.	Gandra, Sumanth: 1 article (09/2022)
6.	George, Ige: 1 article (09/2022)
7.	Harbarth, Stephan: 1 article (09/2022)
8.	Huttner, Benedikt: 1 article (09/2022)
9.	Katukoori, Shashi: 1 article (09/2022)
10.	Mertz, Dominik: 1 article (09/2022)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 01/01/2022 - "In this study, we evaluated the impact of a microbiology nudge on de-escalation to first-generation cephalosporins in hospitalized patients with urinary tract infections secondary to Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates with minimum inhibitory concentrations (MICs) ≤ 16 µg/mL. De-escalation to first generation-cephalosporins was uncommon at MICs = 4-16 µg/mL." 03/01/2022 - "First-generation cephalosporins for the treatment of complicated upper urinary tract infection in adults: A systematic literature review." 01/01/2022 - "Limited impact of a nudge comment in promoting de-escalation to first-generation cephalosporins in urinary tract infections." 09/01/2011 - "Corresponding rates for first-generation cephalosporin resistance in urinary tract infection were 75% and 23.5% (P = .04). " 03/01/2003 - "The results indicated that first-generation cephalosporin alone is an appropriate treatment for pediatric cases of community-acquired urinary tract infection and suggest that antimicrobial combinations should be reserved for serious or critical cases."
2.	Infections 09/01/2008 - "pneumoniae that required hospitalization during 2001-2002 was conducted to identify predictors of metastatic infection, mortality, and the efficacy of first-generation cephalosporins and percutaneous drainage. " 07/01/2019 - "Many periprosthetic joint infections (PJIs) are caused by organisms not susceptible to first-generation cephalosporins. " 04/01/2018 - "First-generation cephalosporins may be the most effective first-line empirical regimen for bacterial skin infections treated in outpatient settings, regardless of methicillin resistance." 07/01/2012 - "Patients with active skin infections were treated with a first-generation cephalosporin. " 09/01/2008 - "pneumoniae with use of first-generation cephalosporins and percutaneous drainage was associated with low rates of mortality, metastatic infection, and complications. "
3.	Peritonitis 07/01/2019 - "Gram-positive cocci are still the primary pathogen of PDAP cases in our center, but demonstrate a high resistance to first-generation cephalosporin, which is the suggested treatment per International Society for Peritoneal Dialysis 2016 Peritonitis Recommendations. " 01/01/1990 - "Eighty-eight percent of the peritonitis episodes were initially treated with a first generation cephalosporin, but results of microbial sensitivity studies led to a change in the initial antibiotic regimen in 23 episodes. " 07/26/2009 - "The majority of streptococcal peritonitis episodes were treated with either intraperitoneal vancomycin (most common) or first-generation cephalosporins for a median period of 13 days (interquartile range 8-18 days). " 07/26/2009 - "When treated with either first-generation cephalosporins or vancomycin for a period of 2 weeks, streptococcal peritonitis is associated with lower risks of relapse, catheter removal and permanent haemodialysis transfer than other forms of PD-associated peritonitis." 01/01/2007 - "Vancomycin or first generation cephalosporins may be used for treating peritoneal dialysis peritonitis due to Gram-positive agents. "
4.	Cellulitis 11/01/2007 - "Noncomplicated, nonfacial cellulitis is most commonly treated using first-generation cephalosporins. " 07/01/2020 - "One-day first generation cephalosporin administration is appropriate for preventing post-surgical complications such as wound infections, UTIs, and vaginal cuff cellulitis in gynecologic cancer surgery." 06/01/2000 - "The first-generation cephalosporin, cephalexin monohydrate, is effective for treating bacterial cellulitis but has not been recommended or studied for treating Lyme disease because of poor in vitro activity. " 11/01/1987 - "We believe that intravenous antibiotic therapy with a first-generation cephalosporin should be used in the acute phase for control of surrounding cellulitis and prevention of bacteremia." 02/01/2010 - "For outpatient cellulitis, PEPs selected clindamycin (30.6%), trimethoprim-sulfa (27.0%), and first-generation cephalosporins (22.7%); methicillin-sensitive S. "
5.	Pyelonephritis 01/01/2016 - "Literature is lacking regarding the utilization of first-generation cephalosporins for the treatment of acute pyelonephritis. " 01/01/2000 - "Our findings show that first generation cephalosporins could be used in our region to treat pyelonephritis in an otherwise healthy child, and that they can provide therapeutic success even in the face of apparent bacterial resistance." 01/01/2000 - "First generation cephalosporins as therapy for uncomplicated pyelonephritis in children. " 09/01/1992 - "Except in the treatment of pyelonephritis, the first-generation cephalosporins are rarely the first line drug of choice for any suspected infection in obstetrics. " 12/01/2017 - "Conclusion Ampicillin and first-generation cephalosporins are associated with a higher bacterial resistance while ceftriaxone proved to have a high efficacy for the treatment of pyelonephritis due to low bacterial resistance. "

Related Drugs and Biologics

1.	Aminoglycosides
2.	Anti-Bacterial Agents (Antibiotics)
3.	Cefazolin (Ancef)
4.	Vancomycin
5.	Third Generation Cephalosporins
6.	Cephalexin (Cefalexin)
7.	Nitrofurantoin (Macrodantin)
8.	Ciprofloxacin (Cipro)
9.	Tobramycin (Nebcin)
10.	Norfloxacin

Related Therapies and Procedures

1.	Therapeutics
2.	Peritoneal Dialysis
3.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
4.	Operative Surgical Procedures
5.	Cholecystectomy