Nucleolin

09/01/2023 - "HAS1411-PTX-ICG displayed effective cytotoxicity and a significant tumor spheroids inhibitory effect owning to the improved internalization of PTX and ICG mediated by TfR1 and nucleolin dual receptors. "
01/01/2023 - "It has been demonstrated through in vitro studies that both types of AS-conjugated nanoassemblies are highly biocompatible, have high cellular uptake efficiency (equivalent concentration of AS: 0.25 μΜ), and enable targeted fluorescence imaging in nucleolin-positive MCF7 and MDA-MB-231 cancer cells compared to MCF10-A normal cells. "
01/01/2020 - "In previous studies, we designed a pseudopeptide, N6L, that binds the nucleolin and blocks the tumor angiogenesis. "
01/13/2016 - "Fluorescent microscopy and flow cytometry studies both revealed highly selective fluorescence staining of MCF-7 (a cancer cell line with nucleolin overexpression) over MCF-10A (normal) cells by the aptamer-functionalized AIE-FSNPs. "
04/01/2015 - "Two aptamers - one targeting nucleolin and a second targeting CXCL12 - are currently undergoing clinical trials for treating cancer patients, and many more are under study. "

09/01/2019 - "In this study, based on nucleolin's active transport property to the nucleus and its affinity with aptamer, we developed a nuclear-targeted delivery system to circumvention of drug resistance in breast cancer (MCF-7/Adr). "
06/01/2016 - "This study found that nucleolin is notably elevated in breast cancer cell lines MCF-7 and MDA-231 compared to nonmalignant breast epithelial MCF-10A cells. "
09/01/2009 - "Studies on expression of nucleolin in breast cancer suggest a possible association to the metastatic cascade. "
12/13/2022 - "Furthermore, we revealed that ZL216 promoted the formation of a nucleolin-ZL216-VHL ternary complex in breast cancer cells and potently induced nucleolin degradation in vitro and in vivo. "
12/13/2022 - "Based on the differential expression of nucleolin on the cell surface, ZL216 could bind to and internalize into breast cancer cells, but not normal breast cells. "

01/01/2018 - "Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity."
01/01/2017 - "Retraction Note to: Nucleolin Promotes TGF-β Signaling Initiation via TGF-β Receptor I in Glioblastoma."
01/01/2015 - "Thus, nucleolin could be a key factor in glioblastoma pathogenesis and considered a therapeutic target, which may also mediate more signaling pathways."
01/01/2015 - "However, the effect of cell surface nucleolin on TGF-β pathway in glioblastoma is not still understood. "
01/01/2015 - "Nucleolin promotes TGF-β signaling initiation via TGF-β receptor I in glioblastoma."

01/01/2019 - "Mechanistic studies revealed that LZ1 acts through binding to nucleolin, whose expression on cell surface is frequently increased in pancreatic cancer cells. "
12/14/2022 - "Correction: Ponzo et al. Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression. "
08/31/2022 - "Nucleolin Therapeutic Targeting Decreases Pancreatic Cancer Immunosuppression."
10/01/2021 - "Nucleolin Aptamer N6L Reprograms the Translational Machinery and Acts Synergistically with mTORi to Inhibit Pancreatic Cancer Proliferation."
01/01/2019 - "These data suggest that LZ1, targeting nucleolin-AMPK-autophagy axis, is a promising lead for the development of therapeutic agents against pancreatic cancer."

12/01/2022 - "Therefore, in the current study, we intend to review the role of nucleolin in the development and progression of lung cancer cells and also evaluate its potential as a prognostic, therapeutic as well as diagnostic marker in lung cancer patients."
01/01/2023 - "To uncover the molecular mechanism of BC-mediated EGFR-TKI resistance in lung cancer, we screened and identified nucleolin and hnRNPK that interact with BC. "
04/29/2022 - "Overall, the results suggested nucleolin overexpression as a poor prognosis predictor and thus a target for therapeutic intervention in lung cancer."
04/29/2022 - "Cell surface expression of nucleolin was evaluated by flow cytometry and subcellular fraction Western blotting in lung cancer cell lines. "
04/29/2022 - "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer."