Polypeptide N-acetylgalactosaminyltransferase

Family of enzymes that catalyze the formation of GalNAcAlpha1-serine/threonine linkages in glycoproteins.

Also Known As:

(1-3)-N-acetyl-beta-galactosaminyltransferase; (1-4)-N-acetyl-beta-D-galactosaminyltransferase; 4-GalNActransferase; GalNAc-T1; GalNAc-T10; GalNAc-T2; GalNAc-T3; GalNAc-T4; GalNAc-T5; GalNAc-T8; GalNAc-transferase; GalNAcT-1; GalNAcT-2; GalNAcT-4; GalNAcT-8; UDP-GPAGAT; UDP-GalNAc-beta-galactose beta 1,4-N-acetylgalactosaminyltransferase; UDP-GalNAc-polypeptide N-acetylgalactosaminyltransferase; UDP-N-acetyl-D-galactosamine polypeptide N-acetylgalactosaminyltransferase-T4; UDP-N-acetylgalactosamine mucin transferase; UDP-N-acetylgalactosamine-beta-galactose beta 1,4-N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-globoside beta-N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-globosidetriaosylceramide beta-3-N-acetylgalactosaminyltransferase; UDP-N-acetylgalactosamine-polypeptide N-acetylgalactosamine transferase; UDPacetylgalactosamine-galactosyl-galactosyl-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase; UDPacetylgalactosamine-protein acetylgalactosaminyltransferase; beta-1,4-N-acetylgalactosaminyltransferase; beta-N-acetylgalactosaminyltransferase; beta1,6N-acetylgalactosaminyltransferase; polypeptide N-acetylgalactosaminyltransferase 1; polypeptide N-acetylgalactosaminyltransferase 10; polypeptide N-acetylgalactosaminyltransferase 2; polypeptide N-acetylgalactosaminyltransferase 3; polypeptide N-acetylgalactosaminyltransferase 4; polypeptide N-acetylgalactosaminyltransferase 5; polypeptide N-acetylgalactosaminyltransferase 8; pp-GalNAc-T10; ppGalNAc-T; Synthase, Globoside; Galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase; Globoside Synthase; Globoside beta GalNAc Transferase; Protein-UDPacetylgalactosaminyltransferase

Networked: 116 relevant articles (0 outcomes, 15 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kohno, Kimitoshi: 12 articles (01/2016 - 04/2002)
2.	Izumi, Hiroto: 8 articles (01/2016 - 04/2002)
3.	Osinaga, Eduardo: 6 articles (07/2018 - 01/2003)
4.	Kohno, K: 5 articles (07/2013 - 09/2002)
5.	Clausen, Henrik: 5 articles (06/2012 - 07/2006)
6.	Nakamura, Yusuke: 4 articles (10/2018 - 04/2010)
7.	Park, Jae-Hyun: 4 articles (10/2018 - 04/2010)
8.	Izumi, H: 4 articles (07/2013 - 09/2002)
9.	Mandel, Ulla: 4 articles (06/2012 - 07/2006)
10.	Ueda, Koji: 3 articles (10/2018 - 01/2016)

Related Diseases

1.	Carcinoma (Carcinomatosis) 03/15/2004 - "In this study, immunohistochemistry was performed to determine the expression level of GalNAc-T3 in 34 cases of pT(2) gallbladder carcinoma to determine the correlation of the GalNAc-T3 expression level with mode of recurrence and postsurgical survival. " 01/01/2003 - "In the present study, we investigated the relationship between immunohistochemical GalNAc-T3 expression and various clinicopathologic factors, including prognosis, in 117 gastric carcinoma patients. " 04/01/1995 - "Studies on the order and site specificity of GalNAc transfer to MUC1 tandem repeats by UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase from milk or mammary carcinoma cells." 12/01/2013 - "GalNAc-T3 was expressed in 40% and 20% of well and poorly differentiated components of follicular carcinomas, respectively. " 01/01/2005 - "GalNAc-T3 was determined to be positive in 37 cases (68.5%) of differentiated carcinomas, but only in 4 cases (33.3%) of undifferentiated carcinomas (p < 0.05). "
2.	Neoplasms (Cancer) 01/01/2023 - "Polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14), a member of the N-acetylgalactosaminyltransferase family, has been considered to be associated with various cancers. " 10/01/2020 - "Immunohistochemical staining was used to detect the expression of GalNAc-T3 and MUC1 in primary tumor specimens. " 08/01/2018 - "Genome-wide analysis of endogenously expressed ZEB2 binding sites reveals inverse correlations between ZEB2 and GalNAc-transferase GALNT3 in human tumors." 01/01/2018 - "Polypeptide N-acetylgalactosaminyltransferase 6 (GALNT6) regulated glycosylation, which is frequently altered in cancers, and play an important role in cancer development. " 01/01/2016 - "The GalNAc-T3 expression was considered to be strongly positive when 20 % or more of the cancer cells showed positive cytoplasmic staining. "
3.	Adenocarcinoma 01/01/2004 - "In the present study, the association of GalNAc-T3 expression with clinicopathologic features of pancreatic adenocarcinoma and patients' survival was examined. " 01/01/2021 - "We reported a rare case of primary hepatoid adenocarcinoma of gallbladder with Mab-21 domain containing 2 (MB21D2), polypeptide N-acetylgalactosaminyltransferase 12 (GALNT12), and AT-rich interaction domain 2 (ARID2) mutations, which was confirmed after surgical resection pathologically. " 01/01/2015 - "The low expression of the GalNAc-T3 usually in adenocarcinoma cell lines was compared with normal bronchial epithelium cell line. " 01/01/2004 - "These findings indicate that the expression of GalNAc-T3 is associated with the differentiation and aggressiveness of ductal adenocarcinoma of the pancreas." 11/01/1997 - "Well-differentiated adenocarcinoma cell lines expressed high levels and moderately differentiated cell lines expressed lower levels of GalNAc-T3. "
4.	Stomach Neoplasms (Stomach Cancer) 04/15/2014 - "Our studies were designed to investigate the expression and prognostic values of GalNAc-T5 and improve the risk stratification in patients with gastric cancer. " 04/15/2014 - "Detection of GalNAc-T5 expression in gastric cancer tissues might add some prognostic information for patients with this disease and lead to a more accurate classification under the TNM stage system." 04/15/2014 - "Intratumoral GalNAc-T5 expression was recognised as an independent prognostic marker for the overall survival of gastric cancer patients. " 04/15/2014 - "Applying the prognostic value of intratumoral GalNAc-T5 density to the conventional clinicopathologic TNM stage system showed a better prognostic value in patients with gastric cancer. " 04/15/2014 - "Low intratumoral GalNAc-T5 density, which was associated with tumour cell differentiation, T classification, N classification, and TNM stage in the two independent sets, was an independent prognosticator for poor prognosis of gastric cancer patients. "
5.	Adenocarcinoma of Lung 01/26/2004 - "This study was designed to detect GalNAc-T3 expression in lung adenocarcinoma by using immunohistochemical staining, and to evaluate the relationship between the GalNAc-T3 expression level and prognosis and recurrence in completely resected lung adenocarcinoma patients. " 12/01/2022 - "We addressed the role of LINC02535 by regulating the miR-30a-5p /GalNAc Transferase 3 (GALNT3) axis to promote the proliferation, migration, and invasion in lung adenocarcinoma (LUAD) cells. " 01/01/2015 - "GalNAc-T3 expression was correlated with the IASLC/ATS/ERS classification and also associated with prognosis of patients with completely resected small (≤2 cm) peripheral lung adenocarcinoma." 01/01/2015 - "Expression and prognostic value of GalNAc-T3 in patients with completely resected small (≤2 cm) peripheral lung adenocarcinoma after IASLC/ATS/ERS classification." 01/26/2004 - "In addition, multivariate analysis of the clinicopathological characteristics of stage I lung adenocarcinoma indicated that the low expression of GalNAc-T3 was a significant independent factor for predicting poor prognosis and early recurrence (P=0.006, rr=2.87 and P=0.019, rr=3.05, respectively). "

Related Drugs and Biologics

1.	Uridine Diphosphate (UDP)
2.	Proteins (Proteins, Gene)
3.	Transferases
4.	Indicators and Reagents (Reagents)
5.	Messenger RNA (mRNA)
6.	MicroRNAs (MicroRNA)
7.	Butyric Acid (Butanoic Acid)
8.	Monoclonal Antibodies
9.	Mucins
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Enzyme Replacement Therapy
2.	Therapeutics
3.	Lymph Node Excision (Lymph Node Dissection)
4.	Gastrectomy