UDP Xylose-Protein Xylosyltransferase

A pentosyltransferase that initiates a series of post-translational modifications necessary for transport and secretion of proteoglycans. It is a key enzyme for glycosylation of the proteoglycan core.

Also Known As:

Networked: 45 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kuhn, Joachim: 11 articles (01/2021 - 03/2002)
2.	Götting, Christian: 10 articles (11/2009 - 03/2002)
3.	Kleesiek, Knut: 10 articles (11/2009 - 03/2002)
4.	Kuhn, J: 6 articles (07/2013 - 01/2000)
5.	Götting, C: 5 articles (06/2007 - 01/2000)
6.	Kleesiek, K: 5 articles (06/2007 - 01/2000)
7.	Prante, Christian: 4 articles (05/2008 - 05/2005)
8.	Schön, Sylvia: 4 articles (12/2006 - 05/2005)
9.	Hendig, Doris: 3 articles (01/2021 - 12/2005)
10.	Dong, Fusheng: 3 articles (06/2018 - 12/2009)

Related Diseases

1.	Choriocarcinoma 06/26/2003 - "High-density tissue-like cultivation of JAR choriocarcinoma cells for the in vitro production of human xylosyltransferase." 06/26/2003 - "This study clearly demonstrates the successful high-density, tissue-like cultivation of JAR choriocarcinoma cells in a hollow fiber bioreactor resulting in an effective production of native human xylosyltransferase." 06/26/2003 - "JAR choriocarcinoma cells cultured with 10% fetal calf serum were found to secrete xylosyltransferase with relatively high activities (1.10 mU l(-1)). " 02/16/2001 - "First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells."
2.	Lung Injury 08/01/2001 - "Changes in xylosyltransferase activity and in proteoglycan deposition in bleomycin-induced lung injury in rat." 08/01/2001 - "This study examined the catalytic activity of UDP-xylosyltransferase in lung tissue and in isolated fibroblasts, as well as the deposition of the proteoglycans versican, biglycan and decorin in rat lung tissue during bleomycin-induced lung injury. "
3.	Neoplasm Metastasis (Metastasis) 12/21/2009 - " this study, human xylosyltransferase-I (XTLY-I) gene, which catalyzes the rate-limited step of proteoglycans biosynthesis, was knocked down by RNA interference (RNAi) to inhibit the proteoglycans biosynthesis in SACC cell line with high tendency of lung metastasis (SACC-M). "
4.	Fibrosis (Cirrhosis) 01/23/2020 - "Xylosyltransferase I expression was considerably and significantly stronger than that of xylosyltransferase II. The following sequences of xylosyltransferase I and xylosyltransferase II expression were determined as follows: vessels >> cell-rich fibrosis > cell-poor fibrosis > synovialis. " 07/05/2013 - "Human xylosyltransferase-I - a new marker for myofibroblast differentiation in skin fibrosis." 12/01/2006 - "Measurement of fibrosis marker xylosyltransferase I activity by HPLC electrospray ionization tandem mass spectrometry." 05/01/2005 - "Serum xylosyltransferase I activity, the new biochemical fibrosis marker, is not affected by renal insufficiency." 07/05/2013 - "Here, we consider the suitability of xylosyltransferase-I (XT-I) as a myofibroblast biomarker in skin fibrosis. "
5.	Systemic Scleroderma (Systemic Sclerosis) 05/01/2005 - "Serum xylosyltransferase I (XT-I) is a marker for the determination of tissue remodeling in systemic sclerosis. " 01/01/2000 - "Elevated serum xylosyltransferase activity correlates with a high level of hyaluronate in patients with systemic sclerosis." 06/01/1999 - "Furthermore, xylosyltransferase activity was correlated with the clinical classification of systemic sclerosis. " 06/01/1999 - "Xylosyltransferase activities in female (mean value 1.28 mU per liter, 90% range 1.10-1.55 mU per liter) and male patients (mean 1.39 mU per liter, 90% range 1.16-1. 57 mU per liter) with systemic sclerosis were significantly increased in comparison with blood donors of a corresponding age. " 06/01/1999 - "Xylosyltransferase activities were determined in serum samples of 30 patients with systemic sclerosis. "

Related Drugs and Biologics

1.	Proteoglycans (Proteoglycan)
2.	Uridine Diphosphate (UDP)
3.	Versicans (Versican)
4.	Biglycan
5.	Decorin
6.	Bleomycin (Blenoxane)
7.	Proteins (Proteins, Gene)
8.	Enzymes
9.	Glycosaminoglycans
10.	Biomarkers (Surrogate Marker)

Related Therapies and Procedures

1.	Bioreactors (Bioreactor)
2.	Vasectomy (Vas Occlusion)