Ficolins

Soluble oligomeric defense proteins with lectin-like activity. They initiate the LECTIN pathway of COMPLEMENT ACTIVATION through attached serine proteases and a primitive OPSONIZATION.

Also Known As:

Networked: 114 relevant articles (5 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thiel, Steffen: 15 articles (01/2022 - 08/2009)
2.	Garred, Peter: 12 articles (08/2020 - 09/2008)
3.	Jensenius, Jens C: 9 articles (01/2019 - 08/2009)
4.	Matsushita, Misao: 7 articles (01/2019 - 06/2006)
5.	Zhang, Xiao-Lian: 6 articles (10/2017 - 01/2008)
6.	Bidula, Stefan: 5 articles (01/2019 - 04/2013)
7.	Schelenz, Silke: 5 articles (01/2019 - 04/2013)
8.	Zhang, Jing: 4 articles (01/2020 - 12/2010)
9.	Sexton, Darren W: 4 articles (01/2019 - 04/2013)
10.	Skjoedt, Mikkel-Ole: 4 articles (01/2019 - 12/2011)

Related Diseases

1.	Infections 01/01/2016 - "In this study, we used ficolin-deficient mice to investigate the role of ficolins during lung infection with A. " 02/01/2014 - "[Study on Ficolin-A against infection of Plasmodium berghei in mouse model]." 04/01/2012 - "Future studies should investigate whether M-ficolin may be used as a marker of neutrophil activation during invasive infections. " 01/01/2010 - "Initial studies on the impact of FCN2 polymorphisms or low L-ficolin levels do not seem to show major associations with respiratory infection. " 01/01/2021 - "Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation."
2.	Inflammation (Inflammations) 01/01/2017 - "Collectively, results from this study demonstrate that ficolins are not involved in host response to LPS-induced systemic inflammation." 09/09/2019 - "We hypothesize that increased serum M-ficolin levels are associated with higher disease activity in JIA and further, the results indicate that MASP-1, MASP-3 and CL-K1 are markers of inflammation." 01/01/2019 - "fumigatus, pointing towards a similar effect of the ficolins in non-sterile mouse models of inflammation. " 05/01/2013 - "We conclude that ficolin-A may play an important role in the innate defense against Aspergillus by opsonizing conidia, immobilizing this fungus through enhanced adherence to epithelial cells and modulation of inflammation. " 03/01/2012 - "These results emphasize a new function of M-ficolin, different from ficolin pathogen recognition, i.e., a participation to neutrophil adhesion potentially important in early inflammation, as nanomolar agonist concentrations are sufficient to mobilize M-ficolin to the neutrophil surface. "
3.	Virus Diseases (Viral Diseases) 01/01/2012 - "However, little is known about the role of L-ficolin during viral infections in vivo. " 08/01/2009 - "These findings provide new insights into the biological functions of L-ficolin in clinically important hepatic viral diseases." 09/01/2014 - "Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity. " 09/01/2012 - "The ficolins are a related group of innate immune proteins that are present at relatively high concentrations in serum, but also in respiratory secretions; however, there has been little study of the role of ficolins in viral infection. " 12/26/2013 - "Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study."
4.	Human Influenza (Influenza) 12/26/2013 - "Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study."
5.	Rheumatoid Arthritis 12/01/2013 - "M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis." 12/01/2013 - "To assess plasma M-ficolin concentrations in disease-modifying antirheumatic drug (DMARD)-naive patients with early rheumatoid arthritis (RA), to investigate the correlation of M-ficolin concentrations with disease activity markers, and to determine the predictive value of M-ficolin with respect to the Disease Activity Score in 28 joints (DAS28). " 01/01/2021 - "In the past few decades, accumulating evidence have suggested that ficolins play a major role in the onset and development of several autoimmune diseases (ADs), including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), Type 1 diabetes (T1D), inflammatory bowel disease (IBD), etc. In this review, we synthesized previous literatures and recent advances to elucidate the immunological regulations of ficolins and discuss the potential diagnostic ability of ficolins in ADs, as well as giving an insight into the future therapeutic options for ficolins in ADs."

Related Drugs and Biologics

1.	Mannose-Binding Lectin (Mannan-Binding Lectin)
2.	Ficolins
3.	Lectins
4.	Complement System Proteins (Complement)
5.	Cytokines
6.	Proteins (Proteins, Gene)
7.	Mannose-Binding Protein-Associated Serine Proteases (Mannose-Binding Protein-Associated Serine Protease)
8.	Collectins (Collectin)
9.	Serine Proteases (Serine Protease)
10.	Vaccines

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Glycemic Control
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
5.	Transplantation