Iodothyronine Deiodinase Type II

An enzyme responsible for T4 (3,5,3',5'-tetraiodothyronine) to T3 (3,5,3'-TRIIODOTHYRONINE) conversion. May contribute to increasing T3 THYROID HORMONE production in patients with GRAVES DISEASE.

Also Known As:

2 Selenodeiodinase, Type; 2, Selenodeiodinase Type; 5'-Deiodinase, Type II; Enzyme, DIO2; Enzyme, TXDI2; II 5'-Deiodinase, Type; Selenodeiodinase, Type 2; Type 2, Selenodeiodinase; Type II 5' Deiodinase; DIO2 Enzyme; Selenodeiodinase Type 2; TXDI2 Enzyme; Type 2 Deiodinase (D2); Type 2 Selenodeiodinase; Type II 5'-Deiodinase; Type II Iodothyronine Deiodinase

Networked: 33 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Peroxidases: 304
      - Iodide Peroxidase: 1819
        Iodothyronine Deiodinase Type II: 33
        human DIO2 protein
        mouse Dio2 protein
        rat Dio2 protein

Experts

1.	Bianco, Antonio C: 3 articles (05/2010 - 03/2004)
2.	Harney, John W: 2 articles (05/2014 - 06/2005)
3.	Dora, José Miguel: 2 articles (03/2014 - 06/2005)
4.	Maia, Ana Luiza: 2 articles (03/2014 - 06/2005)
5.	Christoffolete, Marcelo A: 2 articles (05/2010 - 03/2004)
6.	Visser, Theo J: 2 articles (08/2007 - 06/2007)
7.	Araki, O: 2 articles (07/2001 - 11/2000)
8.	Hosoi, Y: 2 articles (07/2001 - 11/2000)
9.	Mizuma, H: 2 articles (07/2001 - 11/2000)
10.	Mori, M: 2 articles (07/2001 - 11/2000)

Related Diseases

1.	Heart Diseases (Heart Disease) 04/11/2006 - "To assess the potential efficacy of TH in treating heart disease, type 2 deiodinase (D2), which converts the prohormone thyroxine to active triiodothyronine (T3), was expressed transiently in mouse hearts by using the tetracycline transactivator system. "
2.	Hypothyroidism 10/01/2001 - "Functional evidence for the presence of type II 5'-deiodinase in somatotropes and its adaptive role in hypothyroidism." 07/01/1984 - "The results suggest that the increase in whole pituitary type II 5'-deiodinase activity associated with hypothyroidism is due largely or totally to increases occurring within somatotrophs and mammotrophs. " 06/01/2012 - "Comparison of the effects on gene expression observed in D3 deficiency with those in hypothyroidism, hyperthyroidism, and type 2 deiodinase (D2) deficiency revealed that the negative genes are more sensitive to D2 and D3 deficiencies than the positive genes. " 10/01/1990 - "The sensitivity to T4 replacement correlated with the degree of the stimulation of the type II 5'deiodinase (5'D-II) by hypothyroidism, whereas the response to exogenous T3 correlated with the fraction of the tissue T3 that derives from plasma T3 and inversely with the plasma T3 concentration required to saturate 50% of the nuclear receptors as reported in previous studies.(ABSTRACT TRUNCATED AT 250 WORDS)" 11/01/1999 - "Increase in type II 5'deiodinase activity and the number of binding sites point to an adaptive increase in response to thiocyanate induced hypothyroidism to maintain the cellular T3 levels within a narrow limit."
3.	Insulin Resistance 06/01/2007 - "In addition, we analysed the Thr92Ala polymorphism in the type 2 deiodinase (D2), which was recently associated with insulin resistance. " 03/01/2014 - "To study whether the D2 Thr92Ala polymorphism-a genetic marker that is associated with reduced thyroid type 2 deiodinase (D2) activity, increased insulin resistance, and risk for type 2 diabetes-is associated with disrupted placental D2 activity and with glycemic control and gestational outcomes. " 06/01/2005 - "The single-nucleotide polymorphism A/G in the type 2 deiodinase (D2) gene predicts a threonine (Thr) to alanine (Ala) substitution at codon 92 (D2 Thr92Ala) and is associated with insulin resistance in obese patients. "
4.	Type 2 Diabetes Mellitus (MODY) 03/01/2014 - "To study whether the D2 Thr92Ala polymorphism-a genetic marker that is associated with reduced thyroid type 2 deiodinase (D2) activity, increased insulin resistance, and risk for type 2 diabetes-is associated with disrupted placental D2 activity and with glycemic control and gestational outcomes. "
5.	Body Weight (Weight, Body) 08/01/1986 - "To study the effect of rT3 on the 5'-deiodinase type II (5'D-II) of rat brain cortex and anterior pituitary, daily infusions of rT3 at rates of 0.5, 1.5, 4.5, and 13.5 nmol/day X 100 g body weight were given to a total of 87 hypothyroid rats. "

Related Drugs and Biologics

1.	Thyroxine (Levothyroxine)
2.	Triiodothyronine (Liothyronine)
3.	Trans-Activators (Trans-Acting Factor)
4.	Tetracycline (Achromycin)
5.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
6.	Genetic Markers (Genetic Marker)
7.	Thyroid Hormones
8.	Enzymes
9.	Messenger RNA (mRNA)
10.	Thyroid Hormone Receptors beta (TR beta)

Related Therapies and Procedures

1.	Glycemic Control