Ursolic Acid

A pentacyclic triterpene that co-occurs with its isomer OLEANOLIC ACID in several plant species, and occurs in large amounts in FRUITS (such as CRANBERRIES; PEARS; PLUMS; and OLIVES), MEDICINAL HERBS, and other plants.

Also Known As:

Merotaine; 3 Epi Ursolic Acid; 3 Epiursolic Acid; 3alpha Ursolic Acid; 3beta Ursolic Acid; Oleanolate, Sodium; (+)-Ursolic Acid; (3 beta)-3-Hydroxyurs-12-en-28-oic Acid; 3-Epi-Ursolic Acid; 3-Epiursolic Acid; 3alpha-Ursolic Acid; 3beta-Ursolic Acid; Olean-12-en-28-oic Acid, 3-Hydroxy-, Sodium Salt (1:1), (3beta)-; Sodium Oleanolate; Ursolic Acid Monosodium Salt; Ursolic Acid Sodium Salt; Ursolic Acid, (3beta)-Isomer, 2-(14)C-Labeled; Ursolic Acid, (3beta)-Isomer, Monopotassium Salt

Networked: 763 relevant articles (60 outcomes, 170 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Triterpenes: 2493
      - Pentacyclic Triterpenes: 108
        Ursolic Acid: 763
      - Sapogenins: 26
        Ursolic Acid: 763

Experts

1.	Shao, Jingwei: 15 articles (01/2021 - 05/2014)
2.	Jia, Lee: 8 articles (11/2020 - 05/2014)
3.	Fan, Lulu: 8 articles (01/2019 - 01/2017)
4.	Slaga, Thomas J: 8 articles (01/2019 - 06/2009)
5.	Zheng, Guirong: 8 articles (03/2018 - 11/2016)
6.	Zhu, Xuan: 7 articles (01/2021 - 10/2018)
7.	Zhao, Ruirui: 7 articles (11/2020 - 08/2017)
8.	Lin, Li: 7 articles (06/2019 - 10/2013)
9.	Li, Tao: 7 articles (11/2018 - 11/2016)
10.	Sethi, Gautam: 7 articles (10/2016 - 09/2007)

Related Diseases

1.	Neoplasms (Cancer) 01/26/2021 - "Ursolic acid (UA) is a bioactive compound which has demonstrated therapeutic efficacy in a variety of cancer cell lines. " 04/05/2015 - "The anticancer efficacy of ursolic acid (UA) was limited by poor water solubility, non-specific tumor distribution, and low bioavailability. " 01/01/2021 - "This study revealed that ursolic acid played a multitarget and multichannel antitumor role by inhibiting the proliferation of tumor cells, inducing apoptosis, and enhancing antiangiogenesis." 01/01/2020 - "However, the anti-cancer effects of ursolic acid require further study. " 03/01/2018 - "In the present study, it is reported that the pro-apoptotic mechanism of ursolic acid potently suppressed the cell proliferation of human prostate LNCaP cancer cells. "
2.	Inflammation (Inflammations) 01/01/2022 - "Previous studies have shown that ursolic acid (UA) represses inflammation and oxidative stress, contributing to neuroprotection. " 12/01/2021 - "The present study investigated the effect and underlying mechanisms of ursolic acid (UA) on adipose IR and inflammation in ageing rats. " 01/01/2022 - "Ursolic acid represses influenza A virus-triggered inflammation and oxidative stress in A549 cells by modulating the miR-34c-5p/TLR5 axis." 10/01/2021 - "Ursolic acid inhibits FcεRI-mediated mast cell activation and allergic inflammation." 12/01/2020 - "It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. "
3.	Insulin Resistance 08/01/2012 - "To observe the effects of ursolic acid (UA) on insulin resistance and cell differentiation in 3T3-L1 adipocytes and to explore the mechanisms. " 11/09/2018 - "Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice." 07/01/2012 - "To explore the effects and mechanism of ursolic acid in improving hepatic insulin resistance in KKAy mice with spontaneous type 2 diabetes. " 09/15/2018 - "Synergistic action of ursolic acid and metformin in experimental model of insulin resistance and related behavioral alterations." 08/01/2013 - "To investigate the influences of triterpenoid from Psidium guajava Leaves (ursolic acid) on the proliferation, differentiation of 3T3-L1 preadipocyte, and its possible mechanism treat for insulin resistance. "
4.	Hypoxia (Hypoxemia) 07/30/2022 - "Ursolic Acid Ameliorates the Injury of H9c2 Cells Caused by Hypoxia and Reoxygenation Through Mediating CXCL2/NF-κB Pathway." 01/01/2022 - "In this study, we intend to explore whether ursolic acid (UA) can protect CMECs against hypoxia/reoxygenation (H/R) injury and to detect related molecular mechanism. " 08/01/2021 - "The ursolic acid is white concrete at room temperature, and many studies have elucidated that it can relieve hypoxia and endoplasmic reticulum stress. " 12/01/2018 - "Ursolic acid stimulates UCP2 expression and protects H9c2 cells from hypoxia-reoxygenation injury via p38 signaling." 01/01/2013 - "In the present study, we demonstrated that HCY2, an active fraction of Herba Cynomorii, and its major ingredient ursolic acid (UA) could protect against hypoxia/reoxygenation-induced cell apoptosis in H9c2 cells in vitro and also against ischemia/reperfusion-induced injury in rat hearts ex vivo. "
5.	Arthritis (Polyarthritis) 09/01/2014 - "Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation." 12/01/2015 - "Thus niosomal gel of ursolic acid would be a promising alternative to conventional therapy for safe and efficient treatment of arthritis and musculoskeletal disorders. " 12/01/2015 - "The aim of the present study was to optimize niosomes by experimental design for enhanced transdermal delivery of ursolic acid for the effective treatment of arthritis. " 01/01/2018 - "Ursolic acid rich Ocimum sanctum L leaf extract loaded nanostructured lipid carriers ameliorate adjuvant induced arthritis in rats by inhibition of COX-1, COX-2, TNF-α and IL-1: Pharmacological and docking studies." 03/01/2006 - "We applied Cytometric bead array (CBA) technology for simultaneously measurement of these cytokines in adjuvant inflammatory arthritis induced mice treated with ursolic acid in graded oral doses. "

Related Drugs and Biologics

1.	Triterpenes
2.	Oleanolic Acid
3.	Acids
4.	Glucose (Dextrose)
5.	Silicon Dioxide (Silica)
6.	Carbon Tetrachloride (Tetrachloromethane)
7.	Rosmarinic Acid
8.	caffeic acid
9.	Toll-Like Receptor 4
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chemoprevention
4.	Endurance Training
5.	Ligation