Insulin-Like Peptides

Peptides that include INSULIN-LIKE GROWTH FACTOR 1 (IGF1), and IGF2. They influence brain development through their effects on CELL PROLIFERATION; CELL SURVIVAL; and NEUROGENESIS. They also influence post-embryonic development by serving as HORMONES; NEUROTRANSMITTERS, and GROWTH FACTORS.

Also Known As:

Insulin Like Growth Factors; Central Insulin Like Peptides; Factor, Insulin-Like Growth; Factors, Insulin-Like Growth; Growth Factor, Insulin-Like; Growth Factors, Insulin-Like; ILPs, Central; ILPs, Peripheral; Insulin-Like Peptides, Central; Insulin-Like Peptides, Peripheral; Like Peptides, Insulin; Peptides, Central Insulin-Like; Peptides, Insulin Like; Peptides, Insulin-Like; Peptides, Peripheral Insulin-Like; Peripheral Insulin Like Peptides; Central ILPs; Central Insulin-Like Peptides; Insulin Like Growth Factor; Insulin Like Peptides; Insulin-Like Growth Factor; Insulin-Like Growth Factors; Insulin-Like Peptides (ILPs); Peripheral ILPs; Peripheral Insulin-Like Peptides

Networked: 7371 relevant articles (134 outcomes, 857 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pollak, Michael: 44 articles (01/2022 - 11/2002)
2.	Pollak, Michael N: 35 articles (06/2022 - 10/2003)
3.	Yee, Douglas: 28 articles (10/2021 - 01/2002)
4.	Baxter, Robert C: 26 articles (01/2022 - 03/2002)
5.	Lee, Ho-Young: 26 articles (03/2021 - 06/2002)
6.	Kaaks, Rudolf: 23 articles (06/2022 - 09/2002)
7.	de la Monte, Suzanne M: 23 articles (01/2019 - 02/2005)
8.	Holly, Jeff M P: 22 articles (12/2021 - 01/2003)
9.	Werner, Haim: 21 articles (01/2021 - 06/2004)
10.	Cohen, Pinchas: 21 articles (01/2019 - 06/2002)

Related Diseases

1.	Neoplasms (Cancer) 02/10/2004 - "hGHRH antagonists with improved efficacy could be useful for treatment of cancers that depend on insulin-like growth factors or GHRH." 01/01/2023 - "Numerous studies have shown that the insulin-like growth factor (IGF) pathway is highly associated with tumor initial and progression in several tumors. " 01/01/2023 - "Insulin-like growth factor like family member 2 (IGFL2) is a gene in the IGFL family, located on chromosome 19, whose role in cancer is unclear, and the aim of this study was to investigate the relevance of IGFL2 expression, prognosis, immunity, and mutation in pan-cancer. " 01/01/2021 - "Recent studies have indicated that downregulation of insulin-like growth factor (IGF)-1 and its downstream targets are the main mechanisms underlying the anti-cancer impact of exercise. " 01/01/2020 - "Therefore, we included a unified cohort of HCV genotype 4-related HCCs to study the expression levels of genes involved in the insulin-like growth factor 1 receptor (IGF1R) pathway, which is known to be involved in all aspects of cancer growth and progression. "
2.	Acromegaly 11/03/2023 - "In a patient with typical acromegaly features, insulin-like growth factor (IGF)-I > 1.3 times the upper limit of normal for age confirms the diagnosis. " 07/27/2023 - "High levels of insulin-like growth factor 1 (IGF-1) in patients with acromegaly cause structural and functional changes specific to the disease. " 01/01/2022 - "Insulin-Like Growth Factor 1 in the Early Postoperative Assessment of Acromegaly." 01/01/2022 - "Additionally, there was a trend toward higher standardized insulin-like growth factor 1 (IGF-1) in patients with DG acromegaly than in those with SG acromegaly in the severe OSA group. " 05/01/2021 - "Measurement of serum concentrations of insulin-like growth factor (IGF)-1 is used to diagnose acromegaly in cats. "
3.	Insulin Resistance 11/01/2005 - "These mice have dramatically reduced plasma levels of insulin-like growth factor 1 (IGF1) and enhanced insulin sensitivity. " 11/03/2020 - "However, to the best of our knowledge, there is no study examining its association with insulin resistance and tissue levels of insulin-like growth factor 1 receptor (IGF-1R) and insulin-like growth factor 2 receptor (IGF-2R). " 03/01/2009 - "The aim of this study is to assess fasting serum insulin-like growth factor binding protein-1 (IGFBP-1) as a simple index of insulin sensitivity compared with other simple indices and FSIVGTT. " 05/01/2005 - "Conversely, based on various studies, insulin-like growth factors (IGFs) can improve insulin resistance and stimulate adipocyte adipogenesis. " 03/01/2001 - "It has potential use as a marker of (hepatic) insulin resistance in clinical intervention studies and further implicates the insulin-like growth factor system in the development of macrovascular disease."
4.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "This study investigated the role and mechanism of insulin-like growth factor 2-IGF2BP2 in breast cancer. " 01/01/2021 - "Eligibility criteria included randomized controlled trials that evaluated the effects of physical exercise on the insulin-like growth factor system among women with breast cancer. " 01/01/2020 - "Background: Studies on the association between circulating insulin-like growth factor 1 (IGF1) and prognosis of breast cancer are limited. " 04/01/2017 - "Studies have demonstrated an association between insulin-like growth factor 1 (IGF-1) gene polymorphism and cell proliferation and reduced apoptosis, in addition to its role in breast cancer growth and aggressiveness. " 05/01/2015 - "The aim of this study was to evaluate the association between insulin-like growth factor 1 receptor (IGF-1R) expression in breast cancer tissue and mammographic density and the clinical significance of IGF-1R overexpression. "
5.	Prostatic Neoplasms (Prostate Cancer) 10/01/2020 - "Although a growing body of evidence supports an early-life contribution to prostate cancer (PCa) development, few studies have investigated early-life diet, and only three have examined early-life dairy product intake, a promising candidate risk factor because of its known/suspected influence on insulin-like growth factor levels and height. " 01/01/2020 - "Preclinical, clinical, and population studies have provided robust evidence for an important role for the insulin-like growth factor (IGF) system in the development of prostate cancer. " 01/01/2016 - "Some previous studies have investigated the relationship between insulin-like growth factor-binding protein-3 polymorphism and prostate cancer (PCa) susceptibility; however, the findings from those studies remain inconsistent. " 10/01/2013 - "In this study, we examined the role of insulin-like growth factor receptor-1 (IGF-1R) signaling in MET activation, focusing on prostate cancer cells. " 07/01/2012 - "We surveyed the authors of studies on the association between insulin-like growth factor 1 (IGF-1) and prostate cancer, and 20 meta-analysis methodologists. "

Related Drugs and Biologics

1.	Growth Hormone (Somatotropin)
2.	Insulin-Like Growth Factor I (IGF-1)
3.	Insulin (Novolin)
4.	Glucose (Dextrose)
5.	Messenger RNA (mRNA)
6.	Carrier Proteins (Binding Protein)
7.	Proteins (Proteins, Gene)
8.	Leptin
9.	Intercellular Signaling Peptides and Proteins (Growth Factors)
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Transplantation
4.	Percutaneous Coronary Intervention
5.	Injections