Hemorrhagic Cystitis

A diffuse inflammation of the URINARY BLADDER characterized by HEMATURIA due to bleeding from the bladder mucosa. Hemorrhagic cystitis is most often associated with infections, e.g., HUMAN ADENOVIRUS INFECIONS, but may also be due to other noninfectious etiologies: CHEMOTHERAPY with certain drugs, e.g., CYCLOPHOSPHAMIDE and IFOSFAMIDE, and RADIOTHERAPY.

Also Known As:

Cystitis, Hemorrhagic

Networked: 1025 relevant articles (80 outcomes, 70 trials/studies)

Relationship Network

Disease Context: Research Results

Urogenital Diseases: 126

Related Diseases

1.	Water Intoxication
2.	Neoplasms (Cancer)
3.	Hemorrhage
4.	Interstitial Cystitis (Interstitial Cystitis, Chronic)
5.	Overactive Urinary Bladder (Overactive Bladder)

Experts

1.	Hirsch, Hans H: 9 articles (12/2021 - 08/2005)
2.	Chancellor, Michael B: 7 articles (01/2021 - 04/2013)
3.	Chen, Huan: 6 articles (07/2018 - 01/2007)
4.	Han, Wei: 6 articles (07/2018 - 01/2007)
5.	Champlin, Richard E: 5 articles (01/2021 - 08/2009)
6.	Laskin, Benjamin L: 5 articles (12/2020 - 10/2011)
7.	Huang, Xiao-Jun: 5 articles (07/2018 - 01/2007)
8.	Liu, Kai-Yan: 5 articles (07/2018 - 01/2007)
9.	Xu, Lan-Ping: 5 articles (07/2018 - 01/2007)
10.	Ribeiro, Ronaldo A: 5 articles (12/2015 - 02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hemorrhagic Cystitis:

1.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/01/2023 - "Evaluation of the Efficacy of Lactobacillus acidophilus in the Treatment of Cyclophosphamide-induced Hemorrhagic Cystitis in Wistar Rats." 01/01/2023 - "Thus, this study aimed to evaluate the effects of using Lactobacillus acidophilus NCFM in the treatment of cyclophosphamide-induced hemorrhagic cystitis in Wistar rats. " 11/01/2018 - "In this study, we investigated the effects of pomegranate on alleviating cyclophosphamide-induced hemorrhagic cystitis (HC). " 02/01/2001 - "Cyclophosphamide-induced hemorrhagic cystitis in rats that underwent colocystoplasty: experimental study." 06/01/1994 - "The toxicity from the preparative regimen was similar to that of cyclophosphamide and TBI except that none of the patients in the study had hemorrhagic cystitis or veno-occlusive disease. "
2.	Mesna (Coenzyme M)FDA LinkGeneric 03/01/2021 - " and relevance: Our study results do not support the use of mesna in preventing hemorrhagic cystitis. " 11/01/1991 - "Although previous reports had suggested that the sulfhydryl-containing compound mesna might be superior to forced diuresis in preventing hemorrhagic cystitis, there were concerns about the effect of mesna on engraftment in these studies. " 01/01/2017 - "Because the patient presented with hemorrhagic cystitis due to CY, we also implemented mesna administration by bladder perfusion. " 11/01/2015 - "Continuous IV infusion of MESNA can prevent hemorrhagic cystitis in HSCT and retain MESNA concentration in urine." 09/01/2015 - "We observed similar incidence rate for hemorrhagic cystitis in both patient groups concomitantly treated with or without mesna [9/583 (1.5%) vs 8/425 (1.8%) respectively, p = 0.08]. "
3.	Ifosfamide FDA LinkGeneric 05/09/2022 - "The aim of this study was to evaluate the protective effect of isopropyl gallate (IPG) against ifosfamide (IFOS)-induced hemorrhagic cystitis in mice. " 01/01/2023 - "Here, we investigate the molecular mechanism of action of gingerols, Zingiber officinale bioactive molecules, as an alternative treatment for ifosfamide-induced hemorrhagic cystitis. " 01/01/2021 - "Ifosfamide (IFS) has potential complications such as nephropathy and hemorrhagic cystitis (HC). " 12/01/2020 - "Correction to: α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice." 10/01/2020 - "Hemorrhagic cystitis (HC) is the major dose-limiting adverse effect of the clinical use ifosfamide (IFOS). "
4.	Oxygen (Dioxygen)IBA 10/01/2015 - "To analyze the efficacy of hyperbaric oxygen for the treatment of radiation-induced hemorrhagic cystitis and to identify factors associated with successful treatment. " 02/01/1999 - "Radiation induced hemorrhagic cystitis that does not respond to standard regimens can be successfully treated with hyperbaric oxygen. " 12/01/2012 - "Hyperbaric oxygen (HBO) has been demonstrated to be an effective treatment for radiation-induced hemorrhagic cystitis not responding to conventional management. " 06/01/2003 - "We assess the efficacy of hyperbaric oxygen for treatment of hemorrhagic cystitis. " 10/01/2015 - "Refractory radiation-induced hemorrhagic cystitis can be successfully and safely treated with hyperbaric oxygen. "
5.	Proteins (Proteins, Gene)FDA Link 01/01/2019 - "IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis." 07/01/2009 - "The results of the present study reveal that protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of CP-induced hemorrhagic cystitis. " 05/01/1983 - "Hemorrhagic cystitis was much more common in protein free groups compared to rats on regular diets (55 vs 11%, P less than 0.01). " 01/01/2018 - "Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis." 01/01/2018 - "Therapeutic exploitation of IPSE, a urogenital parasite-derived host modulatory protein, for chemotherapy-induced hemorrhagic cystitis."
6.	Cidofovir (Vistide)FDA Link 12/01/2019 - "Six months post-allo-HSCT, adenovirus hemorrhagic cystitis occurred, which has been in remission after a single dose of intravesical cidofovir. " 01/01/2018 - "Efficacy of Cidofovir in Treatment of BK Virus-Induced Hemorrhagic Cystitis in Allogeneic Hematopoietic Cell Transplant Recipients." 08/01/2007 - "In this study, we report a five-yr-old boy who presented with adenovirus-associated hemorrhagic cystitis 68 days after renal transplant and was successfully treated with reduction of immunosuppression and an intermediate dose of intravenous cidofovir." 01/01/2020 - "He was treated for adenovirus hemorrhagic cystitis with intravenous cidofovir 1 mg/kg/day, every three days for three weeks, with good clinical response. " 01/01/2018 - "Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant."
7.	Tacrolimus (Prograf)FDA LinkGeneric 10/01/2015 - "Intravesical tacrolimus is a safe, minimally invasive, and promising treatment option for radiation hemorrhagic cystitis. " 09/19/2023 - "Intravesical liposomal tacrolimus for hemorrhagic cystitis: a phase 2a multicenter dose-escalation study." 04/01/2013 - "Intravesical liposomal tacrolimus may be a promising approach as an orphan drug indication for hemorrhagic cystitis." 01/01/2014 - "New therapy, such as intravesical immunosuppression with local tacrolimus formulation is being developed for the treatment of radiation hemorrhagic cystitis. " 04/01/2013 - "Development of potential orphan drug therapy of intravesical liposomal tacrolimus for hemorrhagic cystitis due to increased local drug exposure."
8.	Alprostadil (Muse)FDA LinkGeneric 01/01/2021 - "This study is the first report describing the special role of intravesical alprostadil in refractory cases of BK virus-associated hemorrhagic cystitis. " 01/01/2021 - "Intravesical alprostadil as a promising agent in BK virus-associated hemorrhagic cystitis: A report of a refractory case." 08/01/1995 - "PGE1 bladder instillations is a safe and useful treatment for severe, life-threatening late-onset hemorrhagic cystitis after allogeneic BMT." 01/01/2021 - "In such refractory cases, clinicians can use intravesical alprostadil rather than invasive therapies in the treatment of BK virus-hemorrhagic cystitis." 01/01/1990 - "Prostaglandin E1 bladder instillations to control severe hemorrhagic cystitis."
9.	Amifostine (Ethyol)FDA LinkGeneric 01/01/2006 - "This study demonstrated the efficacy of amifostine in prevention of cyclophosphamide-induced hemorrhagic cystitis." 03/01/1999 - "Evaluation of uroprotective efficacy of amifostine against cyclophosphamide induced hemorrhagic cystitis." 03/01/1999 - "The role of amifostine in the prevention of cyclophosphamide-induced hemorrhagic cystitis (HC) was evaluated in the rat model. " 01/01/2006 - "Comparison of uroprotective efficacy of mesna and amifostine in Cyclophosphamide- induced hemorrhagic cystitis in rats." 01/01/2007 - "Amifostine and glutathione prevent ifosfamide- and acrolein-induced hemorrhagic cystitis."
10.	aluminum sulfate (alum)IBA 01/01/2018 - "Re: Safety and Efficacy of Intravesical Alum for Intractable Hemorrhagic Cystitis: A Contemporary Evaluation." 11/01/2016 - "Safety and efficacy of intravesical alum for intractable hemorrhagic cystitis: A contemporary evaluation." 05/01/2020 - "This case demonstrates the efficacy and safety of alum irrigation in patients with adenovirus hemorrhagic cystitis." 05/01/2020 - "Alum irrigation for the treatment of adenovirus induced hemorrhagic cystitis in a kidney transplant recipient." 01/01/1993 - "Intravesical alum instillation is an increasingly common treatment for hemorrhagic cystitis. "

Therapies and Procedures

1.	Therapeutics 11/01/2023 - "Cellular therapy seems to be an innovative therapeutic alternative for which mesenchymal stem cells (MSCs) have been shown to be effective for interstitial and hemorrhagic cystitis. " 04/01/2005 - "HBO2 therapy is an effective treatment for radiation-induced hemorrhagic cystitis, with reported response rates ranging from 76% to 100%. " 10/20/2023 - "Erratum: Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation." 06/28/2021 - "A promising therapy for hemorrhagic cystitis." 01/01/2021 - "Third-Party BK Virus-Specific Cytotoxic T Lymphocyte Therapy for Hemorrhagic Cystitis Following Allotransplantation."
2.	Radiotherapy 09/01/2014 - "Technological advances in radiation therapy have resulted in greater treatment efficacy, with significant reduction in side-effects such as hemorrhagic cystitis. " 09/01/1999 - "This technique is particularly useful in the treatment of intractable hemorrhagic cystitis secondary to pelvic radiation therapy. " 04/01/2016 - "Multivariate analysis showed independent effects of pelvic radiation therapy (p = 0.001) and delayed onset of hemorrhagic cystitis (p = 0.0444). " 12/20/2023 - "The patient developed radiation-induced hemorrhagic cystitis 2 years and 3 months after radiotherapy. " 12/20/2023 - "Radiation-induced hemorrhagic cystitis is a late complication of radiotherapy, and in rare cases, refractory. "
3.	Drug Therapy (Chemotherapy) 01/01/2018 - "Chemotherapy-induced hemorrhagic cystitis (CHC) can be difficult to manage. " 01/01/2016 - "Hemorrhagic cystitis (HC), a rare but serious disease that may affect patients after pelvic radiation or systemic chemotherapy, has significant unmet medical needs. " 09/01/2007 - "Hemorrhagic cystitis (HC) is a known complication of oxazophosphorine chemotherapy. " 10/01/2005 - "Severe hemorrhagic cystitis can be a devastating complication of chemotherapy. " 11/01/1999 - "There were no episodes of hemorrhagic cystitis following mobilization chemotherapy. "
4.	Intravesical Administration 09/01/2016 - "To evaluate the early histological effects of the intravesical instillation of platelet-rich plasma (PRP) in rabbit models of interstitial and hemorrhagic cystitis. " 08/01/1995 - "PGE1 bladder instillations is a safe and useful treatment for severe, life-threatening late-onset hemorrhagic cystitis after allogeneic BMT." 10/01/1992 - "This study reveals that hemorrhagic cystitis in the rat model may be prevented by prophylactic continuous bladder irrigation with carboprost tromethamine, whereas established hemorrhagic cystitis may be treated effectively with intravesical instillation of carboprost tromethamine. " 11/01/2006 - "Our results are the first demonstration that intravesical administration of acrolein induces hemorrhagic cystitis. " 01/01/2005 - "Intravesical instillation of cidofovir in a BMT recipient with intractable hemorrhagic cystitis resulted in clinical improvement. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 09/01/2014 - "The aim of this study was to evaluate the usefulness of ultrasonography in the diagnosis of hemorrhagic cystitis following bone marrow transplantation in children. " 08/01/2015 - "Patients who received bone marrow transplantation (BMT) had significantly longer duration of hemorrhagic cystitis than those who did not receive BMT (p < 0.05). " 03/01/2015 - "Łasecki Ultrasonography in the diagnosis of hemorrhagic cystitis - a complication of bone marrow transplantation in pediatric oncology patients." 02/01/2015 - "Hemorrhagic cystitis (HC) is a troublesome and potentially life-threatening complication of bone marrow transplantation (BMT). " 09/01/2014 - "Ultrasonography in the diagnosis of hemorrhagic cystitis - a complication of bone marrow transplantation in pediatric oncology patients."