Non-Erosive Reflux Disease

A type of gastroesophageal reflux disease with acid reflux-related symptoms, but that does not affect the integrity of the ESOPHAGEAL MUCOSA.

Also Known As:

Disease, Non-Erosive Reflux; Diseases, Non-Erosive Reflux; GERD, Non-Erosive; NERD Non Erosive Reflux Disease; Non Erosive GERD; Non-Erosive Reflux Diseases; Reflux Disease, Non-Erosive; Reflux Diseases, Non-Erosive; NERD Non-Erosive Reflux Disease; Non Erosive Reflux Disease; Non-Erosive GERD

Networked: 278 relevant articles (41 outcomes, 56 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 1042
- Gastrointestinal Diseases: 5874
  - Esophageal Diseases: 379
    - Deglutition Disorders: 9385
      - Esophageal Motility Disorders: 515
        Gastroesophageal Reflux: 12198
        Non-Erosive Reflux Disease: 278

Related Diseases

1.	Gastroesophageal Reflux (GERD)
2.	Peptic Esophagitis (Reflux Esophagitis)
3.	Dyspepsia (Indigestion)
4.	Esophagitis
5.	Hypersensitivity (Allergy)

Experts

1.	Iwakiri, Katsuhiko: 21 articles (01/2022 - 01/2009)
2.	Kawami, Noriyuki: 15 articles (01/2022 - 01/2009)
3.	Kinoshita, Yoshikazu: 15 articles (01/2022 - 05/2007)
4.	Miwa, Hiroto: 9 articles (08/2016 - 05/2007)
5.	Kusano, Motoyasu: 8 articles (08/2016 - 12/2008)
6.	Sakamoto, Choitsu: 8 articles (07/2015 - 01/2009)
7.	Hoshikawa, Yoshimasa: 7 articles (01/2022 - 01/2017)
8.	Hoshino, Shintaro: 7 articles (01/2022 - 01/2017)
9.	Savarino, Vincenzo: 7 articles (12/2020 - 03/2009)
10.	Umezawa, Mariko: 7 articles (01/2019 - 01/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Non-Erosive Reflux Disease:

1.	Proton Pump InhibitorsIBA 02/01/2011 - "Proton pump inhibitors (PPIs) are less effective in non-erosive reflux disease (NERD) patients than in reflux oesophagitis patients. " 01/01/2016 - "Proton-pump inhibitors (PPIs) have been proved as safe and effective ways to treat patients with non-erosive reflux disease (NERD). " 05/01/2012 - "We aimed to determine whether reflux- and symptom-related parameters can predict the efficacy of proton pump inhibitors (PPI) in non-erosive reflux disease (NERD). " 05/28/2005 - "Data on the efficacy of proton pump inhibitors in patients with non-erosive GERD (NERD) in Asia is lacking. " 01/01/2016 - "Predictors of proton pump inhibitor failure in non-erosive reflux disease: A study with impedance-pH monitoring and high-resolution manometry."
2.	AcidsIBA 12/01/2003 - "The total percentage acid reflux time was significantly greater in complicated reflux disease than in either erosive reflux oesophagitis (P = 0.024) or non-erosive reflux disease (P = 0.000). " 05/01/2007 - "Non-erosive reflux disease(NERD) is a common condition and acid-suppressing agents are the mainstay of treatment. " 04/01/2009 - "pH-monitoring is considered the gold standard for the detection of acid reflux in patients with non-erosive reflux disease (NERD). " 01/01/2015 - "Integrated upper endoscopy, including endoscopic manometrography and esophageal acid-perfusion test in clinical studies increases the frequency of detection of non-erosive reflux disease and one of its predictors--reduced esophago-gastric pressure gradient." 01/15/2006 - "Our study demonstrated a high oesophageal acid exposure overlap between patients with non-erosive reflux disease-positive and erosive oesophagitis, Barrett's oesophagus and erosive oesophagitis, as well as Barrett's oesophagus and non-erosive reflux disease-positive patients."
3.	Rabeprazole (Aciphex)FDA Link 09/01/2004 - "Recent studies have also indicated that rabeprazole on-demand is cost effective in preventing non-erosive reflux disease (NERD) symptom relapse." 01/01/2014 - "The aim of the study was to monitor the safety and efficacy of rabeprazole administered to patients with erosive or symptomatic non-erosive reflux disease, in real-life healthcare settings. " 01/01/2011 - "The efficacy of rabeprazole 5 mg/day for patients with non-erosive reflux disease (NERD) has not been reported in the literature. " 01/01/2011 - "Randomised clinical trial: a multicentre, double-blind, placebo-controlled study on the efficacy and safety of rabeprazole 5 mg or 10 mg once daily in patients with non-erosive reflux disease." 12/01/2008 - "It is possible to classify non-erosive reflux disease (NERD) patients into endoscopically normal groups and minimal change groups by subjective symptoms and responsiveness to rabeprazole -- a report from a study with Japanese patients."
4.	Esomeprazole (Nexium)FDA Link 07/01/2011 - "This study suggests that esomeprazole is efficacious in treating Chinese patients with non-erosive reflux disease." 07/01/2011 - "We aimed to study esomeprazole for the treatment of non-erosive reflux disease in Chinese patients. " 01/15/2006 - "Data were derived from a subgroup of patients participating in the proGERD study, who had either erosive reflux disease (n = 720) or non-erosive reflux disease (n = 35) and who had biopsy data from two sites [(i) 2 cm above the z-line and (ii) at the z-line], obtained at baseline and following treatment with esomeprazole. " 01/30/2020 - "Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). " 01/15/2006 - "After esomeprazole treatment, baseline thickness and length of papillae were significantly reduced (P < 0.05) at both biopsy sites in non-erosive reflux disease and erosive reflux disease patients (particularly those with Los Angeles grades C and D). "
5.	Omeprazole (Prilosec)FDA LinkGeneric 07/01/2019 - "Efficacy and Safety of AlbisD Compared With Omeprazole 20 mg in Patients With Non-erosive Reflux Disease: A Randomized, Open-label, Active-controlled, Pilot Study." 10/01/2018 - "This prospective, open label, non random (consecutive), experimental study was performed due to compare the therapeutic efficacy of alginate and omeprazole in relieving symptoms of non erosive reflux disease (NERD) and was carried out in the Outpatient Department of Gastroenterology, Dhaka Medical College Hospital, Dhaka, Bangladesh from December 2013 to May 2014. " 02/01/2011 - "Randomised clinical trial: efficacy of the addition of a prokinetic, mosapride citrate, to omeprazole in the treatment of patients with non-erosive reflux disease - a double-blind, placebo-controlled study." 11/01/2013 - "The study showed that sodium alginate was as effective as omeprazole for symptomatic relief in patients with non-erosive reflux disease (Clinicaltrials.gov NCT01338077)." 05/01/2010 - "Randomized controlled trial: roxatidine vs omeprazole for non-erosive reflux disease."
6.	1- (5- (2- fluorophenyl)- 1- (pyridin- 3- ylsulfonyl)- 1H- pyrrol- 3- yl)- N- methylmethanamineIBA 11/01/2023 - "Randomised clinical trial: Efficacy and safety of on-demand vonoprazan versus placebo for non-erosive reflux disease." 01/01/2019 - "To evaluate the efficacy of on-demand therapy using 20-mg vonoprazan for non-erosive reflux disease. " 01/01/2019 - "Efficacy of on-demand therapy using 20-mg vonoprazan for non-erosive reflux disease." 01/01/2019 - "On-demand therapy with 20-mg vonoprazan exerted equivalent effects to continuous PPI maintenance therapy for patients with non-erosive reflux disease." 12/01/2023 - "This study aims to investigate whether vonoprazan could relieve the symptoms of Chinese patients with non-erosive reflux disease (NERD) and whether increased dosage or different times of dosing could increase the response rate of GERD. "
7.	Pantoprazole (Protonix)FDA LinkGeneric 04/30/2021 - "Efficacy of S-pantoprazole 10 mg in the Symptom Control of Non-erosive Reflux Disease: A Phase III Placebo-controlled Trial." 01/01/2018 - "To establish the efficacy of pantoprazole treatment in patients with erosive reflux disease (ERD) and in those with non-erosive reflux disease (NERD), by assessing symptom relief and quality of life. " 04/30/2021 - "We aim to evaluate the efficacy and safety of 10 mg S-pantoprazole for treatment of non-erosive reflux disease (NERD). " 08/01/2007 - "Esomeprazole 20 mg od is superior to placebo for treatment of non-erosive reflux disease (NERD) but clinical trials have not shown any significant differences in efficacy between esomeprazole 20 mg and omeprazole 20 mg or pantoprazole 20 mg od. " 07/01/2008 - "Omeprazole, pantoprazole and lansoprazole have an equivalent potency for normalizing intra-oesophageal acid exposure after 3 days of treatment in non-erosive reflux disease patients."
8.	Dexlansoprazole FDA Link 08/20/2010 - "Dexlansoprazole modified release: in erosive oesophagitis and non-erosive reflux disease." 10/01/2016 - "Expert commentary: Overall, dexlansoprazole offers benefits in its ease of administration and proven efficacy in the healing, maintenance of erosive esophagitis, and symptomatic non-erosive GERD. " 08/01/2011 - "When compared to placebo, dexlansoprazole provided significantly higher maintenance rates for healed esophageal mucosa in patients with erosive esophagitis and symptom control in patients with non-erosive reflux disease. " 01/30/2020 - "Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and erosive esophagitis (EE). " 07/01/2013 - "To compare the efficacy of dexlansoprazole with esomeprazole in healing erosive oesophagitis (EO), the maintenance of healed EO and the treatment of non-erosive reflux disease (NERD). "
9.	PotassiumIBA 01/01/2018 - "The present study examined the pathogenesis of potassium-competitive acid blocker (P-CAB)-resistant non-erosive reflux disease (NERD). " 01/01/2018 - "Pathogenesis of Potassium-Competitive Acid Blocker-Resistant Non-Erosive Reflux Disease." 01/01/2022 - "This study investigated potential determinants of reflux perception in patients with non-erosive reflux disease (NERD) who had reflux-related symptoms on potassium-competitive acid blocker (P-CAB) therapy. " 01/01/2022 - "Determinants of reflux perception in patients with non-erosive reflux disease who have reflux-related symptoms on potassium-competitive acid blocker therapy." 02/01/2017 - "Efficacy of a potassium-competitive acid blocker for improving symptoms in patients with reflux esophagitis, non-erosive reflux disease, and functional dyspepsia."
10.	liu-jun-zi-tangIBA 10/01/2014 - "The aim of this study was to investigate the efficacy of rikkunshito (RKT), a traditional Japanese medicine, combined with proton pump inhibitor (PPI) in patients with PPI-refractory non-erosive reflux disease (NERD). " 10/01/2014 - "A randomized, placebo-controlled, double-blind clinical trial of rikkunshito for patients with non-erosive reflux disease refractory to proton-pump inhibitor: the G-PRIDE study." 07/02/2014 - "Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito." 02/01/2017 - "Tongjlang and rikkunshito showed therapeutic effects for non-erosive reflux disease (NERD) where PPIs failed to show a promising effect. "

Therapies and Procedures

1.	Therapeutics 01/01/2005 - "This form of therapy ("on-demand treatment") has been shown to be effective in patients with non-erosive reflux disease and may reduce the costs associated with long-term therapy. " 04/01/2005 - "This randomized, open-label study enrolled patients diagnosed with non-erosive reflux disease or oesophagitis grade 1 or 2 (Savary-Miller classification) reporting frequent symptomatic relapses (requiring > or =2 courses of antisecretory therapy during the previous year), whose intensity is rated at least moderate (>2 on a 5-point Likert scale). " 01/01/2017 - "Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux disease." 03/01/2016 - "Differences in effectiveness of non-erosive reflux disease therapy were not significant. " 01/10/2013 - "Topic II. Current status and future prospective of medical care of the representative disorders; 2. Non-erosive reflux disease (NERD)--pathophysiology/diagnosis/therapy]."
2.	Endoscopes 12/01/2014 - "Endoscope versus microscope in the diagnosis of esophageal non-erosive reflux disease: a study of 71 cases." 11/01/2013 - "To evaluate the value of Lugol's iodine solution staining combined with endoscope on the diagnosis of non-erosive reflux disease (NERD). " 11/01/2013 - "The evaluation of Lugol's iodine solution staining combined with endoscope for diagnosis of non-erosive reflux disease in clinic."
3.	Lasers (Laser) 01/01/2021 - "Confocal Laser Endomicroscopic Findings of Refractory Erosive Reflux Disease versus Non-Erosive Reflux Disease with Anti-Reflux Mucosectomy: An in vivo and ex vivo Study." 06/01/2012 - "Microalterations of esophagus in patients with non-erosive reflux disease: in-vivo diagnosis by confocal laser endomicroscopy and its relationship with gastroesophageal reflux."
4.	Chinese Traditional Medicine (Traditional Chinese Medicine) 10/18/2022 - "Traditional Chinese medicine based on Tongjiang methodology combined with proton pump inhibitor (PPI) step-down in treating non-erosive reflux disease: a study protocol for a multicentered, randomized controlled clinical trial."
5.	Fundoplication 05/01/2013 - "Blinded retrospective review of impedance-pH tracings from patients with erosive reflux disease (ERD) and non-erosive reflux disease (NERD), and from proton pump inhibitor (PPI)-refractory patients before and after laparoscopic fundoplication. " 03/30/2015 - "Fifty-four percent of non-erosive reflux disease vs 11% of functional heartburn patients (P < 0.003) increased the dose of proton pump inhibitors or underwent fundoplication after the pH test. " 10/01/2013 - "This paper presents commentaries on how endoluminal antireflux procedures compare to laparoscopic fundoplication; new endoscopic procedures being studied to treat refractory gastroesophageal reflux disease (GERD); the new Stretta; the relationship between obesity and proton pump inhibitor (PPI) resistance; data concerning acid hypersensitivity and sensory receptors (vallinoid, TRPV1) causing refractory GERD; whether microscopic esophagitis is relevant in determining symptoms of non-erosive reflux disease (NERD); how concomitant functional gastrointestinal disorders affect the PPI response in NERD; the evidence that a functional esophagus is associated with inflammatory bowel syndrome (IBS); the role of GABA agonists in the treatment of refractory GERD; the role of biofeedback and antidepressants in refractory GERD; and endoluminal fundoplication using the EsophyX device. "