5-HT1F Serotonin Receptor

A serotonin receptor subtype found in the GLOBUS PALLIDUS; HIPPOCAMPUS; PUTAMEN; SUBSTANTIA NIGRA; and TRIGEMINAL NUCLEUS, SPINAL that can modulate the release of CALCITONIN GENE-RELATED PEPTIDE from these nerves. Unlike 5-HT1B RECEPTORS, the activation of 5-HT1F receptors does not cause VASOCONSTRICTION. 5-HT1F receptor antagonists are used for the treatment of MIGRAINE.

Also Known As:

Networked: 74 relevant articles (13 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Goadsby, Peter J: 10 articles (02/2022 - 11/2014)
2.	Reuter, Uwe: 5 articles (09/2017 - 04/2010)
3.	Holland, Philip R: 4 articles (02/2022 - 01/2017)
4.	Johnson, Kirk W: 4 articles (02/2022 - 07/2003)
5.	Färkkilä, Markus: 3 articles (01/2022 - 10/2010)
6.	Martelletti, Paolo: 3 articles (05/2021 - 02/2015)
7.	Schnellmann, Rick G: 3 articles (01/2021 - 01/2018)
8.	Neeb, Lars: 3 articles (09/2017 - 04/2010)
9.	Filla, Sandra A: 3 articles (10/2015 - 07/2003)
10.	Mathes, Brian M: 3 articles (10/2015 - 07/2003)

Related Diseases

1.	Migraine Disorders (Migraine) 06/01/2012 - "It is both scientifically and clinically relevant to review whether a 5-HT(1F) receptor agonist is effective in the acute treatment of migraine. " 04/01/2010 - "5-HT(1F) Receptor agonists: a new treatment option for migraine attacks?" 04/01/2010 - "Study data show that 5-HT(1F) receptor agonists successfully abort migraine attacks. " 01/01/2023 - "The 5-HT1F receptor as the target of ditans in migraine - from bench to bedside." 01/01/2021 - "For the acute treatment of migraine, 5-HT1F receptor agonists, ditans, are now available. "
2.	Pain (Aches) 04/01/1997 - "The localization of the 5-HT1F receptor to areas involved in the mediation and transfer of nociceptive information implies a role for this receptor in pain processing. " 01/01/2021 - "Lasmiditan, a 5-HT1F receptor antagonist, also improved 2-hour pain freedom and freedom from the MBS at 2 hours. " 11/22/2001 - "Recent studies have demonstrated that selective 5-HT(1F) receptor agonists inhibit neurogenic dural inflammation, a model of migraine headache, indicating that these compounds may be effective therapies for the treatment of migraine pain. " 01/01/2021 - "Compared with placebo, calcitonin gene-related peptide receptor antagonists (low to high SOE), lasmiditan (5-HT1F receptor agonist; high SOE), dihydroergotamine (moderate to high SOE), ergotamine plus caffeine (moderate SOE), acetaminophen (moderate SOE), antiemetics (low SOE), butorphanol (low SOE), and tramadol in combination with acetaminophen (low SOE) were significantly associated with pain reduction and increase in mild adverse events. "
3.	Neuralgia (Stump Neuralgia) 01/01/2022 - "In addition, the neuronal 5-HT1F receptor is significantly downregulated in the spinal cord of rats with neuropathic pain. " 01/01/2022 - "5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation." 01/01/2022 - "In this study, we tested the hypothesis that 5-HT1F receptor agonists ameliorate mechanical allodynia in neuropathic pain via the induction of mitochondrial biogenesis and suppression of neuroinflammation. " 01/01/2022 - "Furthermore, the selective 5-HT1F receptor agonist lasmiditan attenuated established mechanical allodynia in rats with neuropathic pain. "
4.	Hyperalgesia 01/01/2022 - "5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation." 01/01/2022 - "In this study, we tested the hypothesis that 5-HT1F receptor agonists ameliorate mechanical allodynia in neuropathic pain via the induction of mitochondrial biogenesis and suppression of neuroinflammation. " 01/01/2022 - "Furthermore, the selective 5-HT1F receptor agonist lasmiditan attenuated established mechanical allodynia in rats with neuropathic pain. "
5.	Neuroinflammatory Diseases 01/01/2022 - "5-HT1F Receptor Agonist Ameliorates Mechanical Allodynia in Neuropathic Pain via Induction of Mitochondrial Biogenesis and Suppression of Neuroinflammation." 01/01/2022 - "In this study, we tested the hypothesis that 5-HT1F receptor agonists ameliorate mechanical allodynia in neuropathic pain via the induction of mitochondrial biogenesis and suppression of neuroinflammation. "

Related Drugs and Biologics

1.	lasmiditan
2.	LY 344864
3.	Serotonin (5 Hydroxytryptamine)
4.	4- fluoro- N- (3- (1- methyl- 4- piperidinyl)- 1H- indol- 5- yl)benzamide
5.	Vasoconstrictor Agents
6.	Serotonin Receptors
7.	Tryptamines (Triptans)
8.	Calcitonin Gene-Related Peptide Receptor Antagonists
9.	Calcitonin Gene-Related Peptide
10.	Monoclonal Antibodies

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Therapeutics