Interferon Lambda

A specific type of interferon that is similar to INTERFERON TYPE I. It primarily functions at barrier epithelial surface, such as the respiratory tract and blood brain barrier

Also Known As:

IFNs, Type III; III IFN, Type; III IFNs, Type; III Interferon, Type; III Interferons, Type; III, Interferon Type; Interferon, Type III; Interferons, Lambda; Interferons, Type III; IFN-Lambda; Interferon Type III; Interferon-Lambda; Lambda Interferons; Type III IFN; Type III IFNs; Type III Interferon; Type III Interferons

Networked: 568 relevant articles (37 outcomes, 63 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kotenko, Sergei V: 19 articles (01/2022 - 01/2003)
2.	Staeheli, Peter: 13 articles (10/2021 - 02/2008)
3.	Hartmann, Rune: 11 articles (01/2022 - 02/2008)
4.	Coyne, Carolyn B: 9 articles (01/2022 - 05/2016)
5.	George, Jacob: 9 articles (12/2019 - 01/2013)
6.	Baldridge, Megan T: 8 articles (01/2021 - 01/2017)
7.	Scagnolari, Carolina: 6 articles (12/2022 - 05/2014)
8.	Nice, Timothy J: 6 articles (01/2022 - 01/2017)
9.	Johnston, Sebastian L: 6 articles (01/2021 - 09/2006)
10.	O'Brien, Thomas R: 6 articles (12/2020 - 10/2009)

Related Diseases

1.	Infections 11/01/2018 - "Our results also suggest that skin keratinocytes play an important role in the skin microenvironment after DENV infection by secreting molecules like type I and type III IFNs, pro-inflammatory molecules, and LL-37, which may contribute to the protection against arboviral infections." 09/01/2011 - "Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful treatment of HCV infection. " 05/01/2011 - "Moreover, high IFN-lambda levels predisposed to spontaneous resolution of HCV infection. " 06/05/2007 - "These results suggest that type III IFNs may be an effective treatment for some poxviral infections." 03/01/2005 - "These results suggest the possibility that IFN-lambda may be therapeutically useful in the treatment of chronic HBV or HCV infection."
2.	Virus Diseases (Viral Diseases) 10/14/2020 - "Among barrier cells, intestinal epithelial cells (IECs) are particularly dependent on type III IFN for the control and clearance of virus infection, but the physiological basis of this selective IFN response is not well understood. " 01/01/2022 - "Prior studies suggest that in mouse intestinal epithelial cells (IECs), type III IFNs are preferentially produced during viral infections and are less cytotoxic than type I IFN. " 12/01/2021 - "Type III IFN (IFN-λ) is now appreciated to have a nonredundant role in viral infection, but few studies have addressed the effects of IFN-λ on immune cells given the more restricted expression of its receptor primarily to the epithelium. " 01/01/2018 - "This study for the first time shows PEDV evasion of the type III IFN response in intestinal epithelial cells, and it provides valuable information on host cell-virus interactions not only for PEDV but also for other enteric viral infections in swine." 02/01/2023 - "Collectively, the data may provide new and comprehensive insights into the virus-host interactions and particularly highlights the potential role of type III IFNs in restricting CCHFV, which may help inform further mechanistic delineation of the viral infection and development of anti-CCHFV strategies."
3.	COVID-19 01/01/2023 - "The efficacy of a single dose of pegylated interferon lambda in preventing clinical events among outpatients with acute symptomatic coronavirus disease 2019 (Covid-19) is unclear. " 01/01/2021 - "Linkage of Lambda Interferons in Protection Against Severe COVID-19." 01/01/2023 - "Pegylated interferon lambda substantially reduced the risk of COVID-19-related hospitalizations or emergency room visits in a recent phase 3, multi-center, randomized, double-blind, placebo-controlled study of high-risk, non-hospitalized adult patients with SARS-CoV-2 infection compared to treatment with placebo. " 10/26/2022 - "Thus, our study provides evidence of restoration of homeostatic levels in DC subset frequencies and circulating levels of Type I and Type III IFNs in convalescent COVID-19 individuals." 01/01/2020 - "Indeed, clinical studies have shown benefit of IFN Is, and there are ongoing trials testing type III IFNs for the treatment of COVID-19. "
4.	Zika Virus Infection 01/01/2020 - "In this mSphere of Influence article, she reflects on how the papers "Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection" (https://doi.org/10.1016/j.chom.2016.03.008) and "A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance" (https://doi.org/10.1126/sciadv.1501462) by Carolyn Coyne's group have made an impact on her, inspiring her to explore immunity in the placenta by indicating the unique innate immune control elicited at the maternal-fetal barrier as well as by providing physiologically relevant model systems for study." 05/11/2016 - "Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection." 01/01/2017 - "Collectively, these data provide important insights into the defense mechanisms used by syncytiotrophoblasts at various stages of human gestation to resist ZIKV infection and new human models to study the role of type III IFNs in the vertical transmission of ZIKV and other viruses associated with congenital disease." 01/01/2019 - "As such, this raises the question of a potential role for type III IFN during ZIKV infection. " 01/01/2019 - "Interferon lambda protects the female reproductive tract against Zika virus infection."
5.	Chronic Hepatitis C 04/01/2017 - "Host factors including single-nucleotide polymorphisms (SNPs) in or near interferon lambda (IFNL) gene are the important factors in predicting response to treatment of chronic hepatitis C (CHC). " 01/01/2015 - "SNPs near the interferon lambda (IFNL) 3 gene are predictors for sustained virological response (SVR) in patients with chronic hepatitis C genotype (GT) 1. In addition, a dinucleotide frame shift in ss469415590 was described, which generates IFNL4. " 01/01/2015 - "Activation of Type I and Type III Interferons in Chronic Hepatitis C." 01/01/2014 - "Predictive value of interferon-lambda gene polymorphisms for treatment response in chronic hepatitis C." 08/01/2010 - "Preclinical and clinical development of pegylated interferon-lambda 1 in chronic hepatitis C."

Related Drugs and Biologics

1.	Interferons
2.	Antiviral Agents (Antivirals)
3.	Interferon Lambda
4.	Ribavirin (Virazole)
5.	Cytokines
6.	Vaccines
7.	KIR Receptors
8.	RHO(D) antibody (anti-D)
9.	Interleukins
10.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Therapeutics
2.	Art Therapy
3.	Intranasal Administration
4.	Investigational Therapies (Experimental Therapy)
5.	Bioreactors (Bioreactor)