Delta Catenin

A CATENIN protein that plays a critical role in cell adhesion and tissue morphogenesis by regulating the surface stability of C-, E-, and N- CADHERINS.

Also Known As:

p120(cas); p120(ctn); p120-catenin; p120cas; p120ctn; Catenins, Delta; Delta-1, Catenin; Protein, CTNND1; Protein, CTNND2; Protein, Catenin p120ctn; CTNND1 Protein; CTNND2 Protein; Cadherin-Associated Src Substrate p120; Catenin Delta-1; Catenin Delta-2; Catenin p120(ctn) Protein; Catenin p120ctn Protein; Catenin, Delta; Delta Catenins; Delta-Catenin; Neurojungin

Networked: 266 relevant articles (3 outcomes, 47 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoskeletal Proteins: 739
    - Catenins: 16285
      - Delta Catenin: 266
        human CTNND1 protein
        human CTNND2 protein
        mouse Ctnnd1 protein
        mouse Ctnnd2 protein
        rat Ctnnd1 protein

Experts

1.	Liu, Yang: 22 articles (01/2022 - 04/2005)
2.	Wang, En-Hua: 16 articles (01/2022 - 07/2007)
3.	Wang, Enhua: 14 articles (01/2018 - 08/2005)
4.	Reynolds, Albert B: 13 articles (01/2021 - 12/2002)
5.	Lu, Qun: 10 articles (10/2022 - 10/2005)
6.	Dai, Shun-Dong: 10 articles (12/2016 - 07/2007)
7.	Wang, Yan: 9 articles (12/2016 - 04/2008)
8.	Miao, Yuan: 9 articles (06/2015 - 04/2008)
9.	Stairs, Douglas B: 8 articles (01/2021 - 04/2011)
10.	Zhang, Di: 8 articles (01/2018 - 08/2008)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2007 - "Accurate categorization of ductal versus lobular neoplasia in the breast with P120ctn immunostaining was effective in all cases. " 01/01/2020 - "In previous studies, we demonstrated that p120ctn is a tumor suppressor and its loss is capable of inducing cancer. " 01/01/2012 - "Studies have demonstrated that p120-catenin plays important roles in cell-cell adhesion, embryonic development, cell proliferation and polarity, tumor cell migration, and cancer progression. " 10/01/2010 - "For most epithelial cancers, studies have demonstrated a reduction of p120(ctn) expression or alteration of its subcellular distribution. " 04/01/2003 - "This study further represents conclusive evidence for a direct involvement of p120(ctn) in malignant tumor cell proliferation. "
2.	Carcinoma (Carcinomatosis) 10/01/1999 - "The aim of this study was to investigate in vivo expression of p120(ctn) in gastric carcinoma and to examine any relationship to pathological characteristics and patient survival. " 05/02/2008 - "delta-Catenin is upregulated in human carcinomas. " 03/01/2008 - "Our findings suggest that p120(ctn) acts as a prognostic factor in bladder tumours and has a primary role to play in the migratory and invasive behaviour of bladder carcinoma cells." 03/01/2008 - "To identify the frequency of change in the expression and localization of p120(ctn) in bladder tumours and its association with clinical outcomes, and to investigate the potential role of p120(ctn) in the migratory and invasive behaviour of bladder carcinoma cells. " 10/01/1999 - "In conclusion, staining for p120(ctn) in gastric carcinoma and dysplasia revealed marked up-regulation of cytoplasmic staining, sometimes associated with reduced membranous expression. "
3.	Ventilator-Induced Lung Injury 11/01/2019 - "Protective role of p120-catenin on mitochondria by inhibiting NLRP3 in ventilator-induced lung injury." 05/20/2015 - "Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury." 08/01/2011 - "Our findings demonstrate that p120-catenin plays a critical protective role in cyclic stretch-induced alveolar barrier dysfunction, and, thus, maintenance of p120-catenin expression may be a novel therapeutic strategy for the prevention and treatment of ventilator-induced lung injury." 04/01/2011 - "This study tested the hypothesis that Rho negative regulator p190RhoGAP is essential for OxPAPC-induced lung barrier protection against ventilator-induced lung injury (VILI), and investigated potential mechanism of p190RhoGAP targeting to adherens junctions (AJ) via p120-catenin. " 12/20/2016 - "p120-catenin (p120) is a cell-cell junction protein known to protect against ventilator-induced lung injury (VILI) that results from improper ventilation of patients. "
4.	Lung Neoplasms (Lung Cancer) 11/01/2021 - "Cytoplasmic p120ctn activates PAK1 via Cdc42/Rac1 activation, constitutively activates ERK in the EGFR downstream signaling, and promotes EGFR-TKI resistance in lung cancer cells. " 11/01/2021 - "Immunohistochemistry detected PAK1, Cdc42, and Rac1 expression in lung cancer with cytoplasmic p120ctn. " 12/01/2016 - "RETRACTED: Kaiso is expressed in lung cancer: Its expression and localization is affected by p120ctn." 01/01/2014 - "Co-expression of delta-catenin and RhoA is significantly associated with a malignant lung cancer phenotype." 06/01/2013 - "Accordingly, the down-regulation and cytoplasmic mislocalization of p120ctn has been reported in all subtypes of lung cancers and is associated with grave prognosis. "
5.	Prostatic Neoplasms (Prostate Cancer) 03/01/2009 - "This study demonstrated, for the first time, the extracellular accumulation of delta-catenin in urine supporting its potential utility for non-invasive prostate cancer detection." 03/01/2009 - "In this study, we investigated the hypothesis of delta-catenin accumulation in the urine of prostate cancer patients and its potential pathways of excretion into extracellular milieu. " 05/02/2008 - "These studies identify E2F1 as a positive transcriptional regulator for delta-catenin, but further suggest the presence of strong negative regulator(s) for delta-catenin in prostate cancer cells with minimal endogenous delta-catenin expression." 03/10/2009 - "We hypothesized that delta-catenin plays a direct role in prostate cancer progression by altering gene profiles of cell cycle regulation and cell survival. " 03/10/2009 - "delta-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles."

Related Drugs and Biologics

1.	oxidized- L- alpha- 1- palmitoyl- 2- arachidonoyl- sn- glycero- 3- phosphorylcholine
2.	Small Interfering RNA (siRNA)
3.	Cadherins (E-Cadherin)
4.	Catenins
5.	Delta Catenin
6.	Proteins (Proteins, Gene)
7.	Protein Isoforms (Isoforms)
8.	beta Catenin
9.	Phosphotransferases (Kinase)
10.	Vimentin

Related Therapies and Procedures

1.	Therapeutics
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Lasers (Laser)
4.	Drug Therapy (Chemotherapy)