Nociceptin Receptor

A member of the opioid subfamily of the G PROTEIN-COUPLED RECEPTORS. It is the receptor for the endogenous neuropeptide nociceptin. It functions in modulating NOCICEPTION and the perception of pain.

Also Known As:

Noci-R; 1 Protein, Opioid-Receptor-Like; 1, Opiate Receptor-Like; FQ Receptor, Orphanin; FQ Receptors, Orphanin; MOR C Protein; Noci R; Opioid Receptor Like 1 Protein; Protein, KOR-3; Protein, MOR-C; Protein, Opioid Receptor-Like; Protein, Opioid-Receptor-Like 1; Receptor, Kappa3-Related Opioid; Receptor-Like 1, Opiate; Receptor-Like Protein, Opioid; Receptors, Nociceptin; Receptors, Orphanin FQ; KOR-3 Protein; Kappa3-Related Opioid Receptor; MOR-C Protein; Nociceptin Receptors; OFQ Receptor; OFQ Receptors; ORL1 Receptor; ORL1 Receptors; Opiate Receptor-Like 1; Opioid Receptor-Like Protein; Opioid-Receptor-Like 1 Protein; Orphanin FQ Receptor; Orphanin FQ Receptors; Receptor, Nociceptin; Receptor, OFQ; Receptor, Orphanin FQ; Receptors, ORL1

Networked: 151 relevant articles (6 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ciccocioppo, Roberto: 6 articles (01/2019 - 05/2002)
2.	Zaveri, Nurulain T: 5 articles (12/2020 - 12/2009)
3.	Massi, Maurizio: 4 articles (11/2009 - 05/2002)
4.	Anthes, John: 4 articles (09/2009 - 12/2008)
5.	Fernandez, Xiomara: 4 articles (09/2009 - 12/2008)
6.	Greenlee, William J: 4 articles (09/2009 - 12/2008)
7.	McLeod, Robbie L: 4 articles (09/2009 - 12/2008)
8.	Tulshian, Deen: 4 articles (09/2009 - 12/2008)
9.	Takeshima, Hiroshi: 4 articles (01/2008 - 06/2003)
10.	Guerrini, Remo: 3 articles (01/2021 - 11/2006)

Related Diseases

1.	Pain (Aches) 12/01/2015 - "Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice." 02/01/2006 - "In the present study, we examined the relationship of pain responses between PGs and N/OFQ using the N/OFQ receptor (NOP) antagonist, N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxy-methyl)benzamide monohydrochloride (JTC-801), and in mice lacking the N/OFQ prepropeptide (ppN/OFQ(-/-)) and the NOP receptor (NOP(-/-)). " 01/01/2021 - "Both agonist and antagonist of N/OFQ receptor were administered to examine their effects on pain and the expression of CGRP in trigeminal ganglia (TG). " 01/01/2012 - "This is particularly intriguing because the NOP receptor/nociceptin system has been primarily linked to behavior and pain regulation, but a role in CNS development or myelination has not been described before. " 01/08/2008 - "Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice."
2.	Alcoholism (Alcohol Abuse) 11/15/2018 - "Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A." 03/01/2008 - "OPRL1 encodes the nociceptin receptor, which has been shown to be involved in alcohol dependence in previous studies. " 11/15/2018 - "Basic investigations support a role for medications that target nociceptin receptors in the treatment of alcohol use disorders. " 11/01/2016 - "Nociceptin Receptor as a Target to Treat Alcohol Use Disorder: Challenges in Advancing Medications Development." 03/01/2008 - "Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence."
3.	Sepsis (Septicemia) 01/01/2023 - "In animal models of sepsis, increased activation of the Nociceptin/Orphanin FQ (N/OFQ) receptor NOP is associated with mortality and NOP antagonists improved survival. " 10/01/2013 - "Recent clinical and animal studies have reported that Noc and its receptor (nociceptin/orphanin FQ [NOP]) are involved in inflammation and sepsis. " 11/01/2014 - "The nociceptin receptor (NOP) and its ligand nociceptin/orphanin FQ (N/OFQ) have been shown to exert a modulatory effect on immune cells during sepsis. "
4.	Opioid-Related Disorders (Opiate Addiction) 02/01/2016 - "Growing evidence indicates that targeting nociceptin receptor (NOP) signaling may have therapeutic efficacy in treating alcohol and opioid addiction. " 09/15/2000 - "The present results confirm and extend previous reports that nociceptin/orphanin FQ is able to abolish morphine-induced conditioned place preference, and raise interest for the possible role of nociceptin/orphanin FQ and ORL1 receptors in the control of opiate abuse."
5.	Diarrhea 05/15/2012 - "Inhibition of the N/OFQ receptor (NOP) by SB612111 significantly ameliorated the clinical disease course in these animals, as indicated by reduced fecal bleeding, improved recovery from diarrhea and weight loss, and a reduction in histopathological alterations. " 11/01/2014 - "Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS."

Related Drugs and Biologics

1.	Nociceptin
2.	Neurokinin-1 Receptors (Neurokinin 1 Receptor)
3.	LY2940094
4.	Opioid Receptors (Opioid Receptor)
5.	Ligands
6.	Opioid Analgesics (Opioids)
7.	Morphine (MS Contin)
8.	Analgesics (Analgesic Drugs)
9.	Peptides (Polypeptides)
10.	Neuropeptides

Related Therapies and Procedures

1.	Spinal Injections
2.	Therapeutics
3.	Analgesia
4.	Injections
5.	Ligation