Subgenomic RNA

RNA that results from VIRUS REPLICATION of partial genomic regions. The process may involve specific internal transcriptional initiation and termination sites.

Also Known As:

Replicon, Subgenomic; Replicon, Subgenomic RNA; mRNA, Subgenomic; Subgenomic Messenger RNA; Subgenomic RNA Replicon; Subgenomic Replicon; Subgenomic Replicon RNA; Subgenomic mRNA; sgmRNA

Networked: 163 relevant articles (4 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Messenger RNA: 115441
      - Subgenomic RNA: 163
    - Viral RNA: 4758
      - Subgenomic RNA: 163

Experts

1.	Neyts, Johan: 5 articles (01/2021 - 04/2006)
2.	Carrasco, Luis: 5 articles (01/2016 - 07/2007)
3.	Sanz, Miguel Angel: 4 articles (01/2016 - 01/2009)
4.	Kanda, Tatsuo: 3 articles (05/2022 - 03/2006)
5.	Oh, Jong-Won: 3 articles (12/2020 - 08/2009)
6.	Paeshuyse, Jan: 3 articles (01/2018 - 04/2006)
7.	Kao, C Cheng: 3 articles (01/2016 - 05/2011)
8.	Hardy, Richard W: 3 articles (07/2013 - 02/2007)
9.	Kato, Nobuyuki: 3 articles (10/2007 - 05/2002)
10.	Moriyama, Mitsuhiko: 2 articles (05/2022 - 02/2022)

Related Diseases

1.	Infections 01/01/2021 - "Despite low analytical sensitivity, both Ag-RDTs detected 100% infection in cell culture-positive samples (n = 15) and were highly effective in distinguishing viable samples from those with subgenomic RNA (66.66%). " 08/01/1985 - "In an earlier study we concluded that tobacco mosaic virus (TMV) infections engender a third subgenomic RNA in infected tissue (P. " 02/23/2023 - "Using this method, we show that viral gene expression is highly correlated across cells suggesting a relatively consistent proportion of viral sgmRNA production throughout infection. " 01/01/2022 - "This recapitulates the relative sgmRNA abundance observed in cells at early points in infection but not at late points. " 01/01/2022 - "Altered subgenomic RNA abundance provides unique insight into SARS-CoV-2 B.1.1.7/Alpha variant infections."
2.	COVID-19 05/28/2022 - "Using the subgenomic RNA (sgRNA) as an active replication marker of SARS-CoV-2, 48 (76.2%), 56 (88.9%), and 63 (100%) of 63 samples with sgRNA positive results tested positive with the SD BIOSENSOR STANDARD Q COVID-19 Ag (Standard Q), the SD BIOSENSOR STANDARD F COVID-19 Ag FIA (Standard F), or the Fujirebio LUMIPULSE G SARS-CoV-2 Ag (Lumipulse) assay, respectively. " 07/01/2023 - "Using a large and diverse panel of virus sequencing data produced as part of the Danish COVID-19 routine surveillance together with information in electronic health registries, we assessed the association of subgenomic RNA levels with demographic and clinical variables of the infected individuals. " 05/01/2023 - "Correction: Detection of SARS-CoV-2 genomic and subgenomic RNA in retina and optic nerve of patients with COVID-19." 01/01/2023 - "Through an in vitro experiment exposing VERO cells to testicular macerates, we observed viral content in all samples, and the subgenomic RNA's presence reinforced the replicative activity of SARS-CoV-2 in testes of the severe COVID-19 patients. " 02/01/2022 - "Characterization of two SARS-CoV-2 subgenomic RNA dynamics in severe COVID-19 patients."
3.	Migraine Disorders (Migraine) 01/01/2006 - "In this study, we identified parthenolide (1), an active component in feverfew, a popular remedy for fever and migraine, as a lead compound with an EC50 value of 2.21 microM against HCV replication in a subgenomic RNA replicon assay system. "
4.	Fever (Fevers) 01/01/2006 - "In this study, we identified parthenolide (1), an active component in feverfew, a popular remedy for fever and migraine, as a lead compound with an EC50 value of 2.21 microM against HCV replication in a subgenomic RNA replicon assay system. "
5.	Lung Injury 12/01/2021 - "Either single-dose or two-dose mucosal administration of AdC7-RBD-tr2 protected mice against SARS-CoV-2 challenge, with undetectable subgenomic RNA in lung and relieved lung injury. "

Related Drugs and Biologics

1.	parthenolide
2.	Proteins (Proteins, Gene)
3.	Subgenomic RNA
4.	Luciferases
5.	RNA (Ribonucleic Acid)
6.	Viral RNA
7.	Viral Nonstructural Proteins
8.	Hepatitis A Antibodies
9.	Heterogeneous-Nuclear Ribonucleoprotein K
10.	Rimantadine

Related Therapies and Procedures

1.	Mucosal Administration
2.	Chinese Traditional Medicine (Traditional Chinese Medicine)
3.	Therapeutics
4.	Length of Stay