beta-Galactoside alpha-2,3-Sialyltransferase

Sialyltransferases that catalyze the transfer of N-ACETYLNEURAMINIC ACID from CYTIDINE MONOPHOSPHATE N-ACETYLNEURAMINIC ACID to the 3-OH of the GALACTOSE residue of N-GLYCANS.

Also Known As:

ST3Gal I; ST3Gal II; ST3Gal III; ST3Gal IV; ST3Gal VI; alpha-2,3-ST(O); 2-3-Sialyltransferase, alpha; 3-alpha-Sialyltransferase, beta-D-Galactoside; CMP ANGS Transferase; CMP N Acetylneuraminate beta Galactoside alpha 2,3 Sialyltransferase; CMP Neu5Ac GAl beta1 3GalNAc alpha 2,3 Sialyltransferase; CMP Neu5Ac Gal1 3GalNAc alpha 2,3 Sialyltransferase; CMPSialic Acid beta Galactosyl 1 3 N Acetylgalactosaminide alpha 2 3 Sialyltransferase; N-Acetylneuraminate-beta-Galactoside alpha-2,3-Sialyltransferase, CMP; Sialyltransferase, Asialofetuin; alpha 2 3 Sialyltransferase; alpha-2,3-Sialyltransferase, CMP N-Acetylneuraminate-beta-Galactoside; alpha-2,3-Sialyltransferase, CMP-Neu5Ac-GAl beta1-3GalNAc; alpha-2,3-Sialyltransferase, CMP-Neu5Ac-Gal1-3GalNAc; alpha-2,3-Sialyltransferase, beta-Galactoside; beta D Galactoside 3 alpha Sialyltransferase; beta Galactoside alpha 2,3 Sialyltransferase; beta1-3GalNAc alpha-2,3-Sialyltransferase, CMP-Neu5Ac-GAl; Asialofetuin Sialyltransferase; CMP N-Acetylneuraminate-beta-Galactoside alpha-2,3-Sialyltransferase; CMP-ANGS-Transferase; CMP-Acetylneuraminate-Galactoside (alpha 2-3)-Sialyltransferase; CMP-Neu5Ac-GAl beta1-3GalNAc alpha-2,3-Sialyltransferase; CMP-Neu5Ac-Gal1-3GalNAc alpha-2,3-Sialyltransferase; CMP-NeuAc-Galactoside (alpha 2-3)-Sialyltransferase; CMPSialic Acid beta-Galactosyl-1-3-N-Acetylgalactosaminide alpha 2-3-Sialyltransferase; Gal beta1,3GalNAc alpha2,3-Sialyltransferase; alpha 2-3-Sialyltransferase; beta-D-Galactoside 3-alpha-Sialyltransferase

Networked: 58 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Sialyltransferases: 490
        beta-Galactoside alpha-2,3-Sialyltransferase: 58
        human ST3GAL1 protein
        human ST3GAL3 protein
        human ST3GAL4 protein

Experts

1.	Peracaula, Rosa: 4 articles (01/2014 - 09/2010)
2.	Pérez-Garay, Marta: 4 articles (01/2014 - 09/2010)
3.	Reis, Celso A: 2 articles (01/2019 - 01/2014)
4.	Jia, Li: 2 articles (08/2017 - 09/2014)
5.	Zhou, Huimin: 2 articles (08/2017 - 09/2014)
6.	Bassagañas, Sònia: 2 articles (01/2014 - 01/2014)
7.	Figueras, Joan: 2 articles (01/2014 - 08/2013)
8.	Arteta, Beatriz: 2 articles (08/2013 - 09/2010)
9.	Pagès, Lluís: 2 articles (08/2013 - 09/2010)
10.	Vidal-Vanaclocha, Fernando: 2 articles (08/2013 - 09/2010)

Related Diseases

1.	Adenocarcinoma 08/01/2013 - "ST3Gal IV overexpressing pancreatic adenocarcinoma MDAPanc-28 cell lines were generated. " 09/01/2010 - "ST3Gal III overexpressing pancreatic adenocarcinoma cell lines Capan-1 and MDAPanc-28 were generated. " 08/01/2013 - "α2,3-Sialyltransferase ST3Gal IV promotes migration and metastasis in pancreatic adenocarcinoma cells and tends to be highly expressed in pancreatic adenocarcinoma tissues." 01/01/2003 - "Alterations of CMP-NeuAc:asialofetuin sialyltransferase activities in human colorectal adenocarcinoma." 01/01/2020 - "It has been reported that ST3Gal IV expression is associated with gastric carcinoma, pancreatic adenocarcinoma and breast cancer. "
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma) 03/01/2009 - "Increased mRNA expression of STs (ST6Gal I, ST3Gal III) has been detected in invasive cervical squamous cell carcinoma. " 02/14/2013 - "In summary, our results showed that the high expression of ST3Gal I and ST6Gal I, in skin tumors, is associated with tumors with greater potential for invasion and metastasis, as in the case of squamous cell carcinoma, and this may be related to their behavior." 02/14/2013 - "The expression of ST3Gal I was observed in actinic keratosis (53%), keratoacanthoma (78%), squamous cell carcinoma (73%) and basal cell carcinoma (32%) with statistic differences between basal cell carcinoma and keratoacanthoma (P=0.0239) and basal cell carcinoma and squamous cell carcinoma (P=0.0096); for ST6Gal I, cytoplasmic expression was noted in actinic keratosis (40%), heterogeneous and cytoplasmic expression was noted in keratoacanthoma (67%), squamous cell carcinoma (41%) and basal cell carcinoma (7%) with statistic differences between basal cell carcinoma and squamous cell carcinoma (P=0.0061) and basal cell carcinoma and keratoacanthoma (P=0.0008). " 10/01/2001 - "ST6Gal I expression was enhanced in squamous cell carcinoma of the cervix (P = 0.026, Mann-Whitney U test), but mRNA expression from the other three STs (ST3Gal I, ST3Gal III, and ST3Gal IV) was significantly down-expressed in squamous cell carcinoma of the cervix compared to the normal cervix (P = 0.003, P < 0.001, and P = 0.001, respectively). " 02/14/2013 - "In this study, it was evaluated the expression of ST3Gal I and ST6Gal I in cutaneous epithelial lesions that include actinic keratosis (n=15), keratoacanthoma (n=9), squamous cell carcinoma (n=22) and basal cell carcinoma (n=28) in order to evaluate if sialyltransferases expression is different in premalignant and in malignant tumors. "
3.	Glioma (Gliomas) 08/15/1991 - "Study of O-glycan sialylation in C6 cultured glioma cells: evidence for post-translational regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by N-glycosylation." 08/14/1992 - "Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors." 02/01/1990 - "The tricyclic antidepressant desipramine, when added to culture medium, gave rise in C6 rat glioma cells to a decrease of the activity of the enzyme asialofetuin sialyltransferase. "
4.	Neoplasms (Cancer) 10/07/2009 - "The overexpression of ST3Gal.I seems to be part of the initial oncogenic transformation of bladder and can be considered when predicting cancer progression and recurrence." 10/07/2009 - "The two ST3Gal.I transcript variants were also equally expressed, independently of cell phenotype or malignancy. " 10/07/2009 - "In muscle-invasive cancers and matching urothelium, ST3Gal.I mRNA levels were as elevated as nonmuscle-invasive cancers. " 11/01/2002 - "The 6 cases that possessed almost the same levels of ST3Gal IV mRNA in primary tumor tissues as those in non-tumor kidneys showed favorable prognoses, as assessed by Kaplan-Meier curve. " 11/01/2002 - "ST3Gal IV mRNA level was decreased in 16 cases of 22 primary RCC tissues compared to 21 non-tumor kidney tissues. "
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2020 - "In this study, we found that ST3Gal IV was downregulated in human cervical cancer tissues compared to normal cervix tissues, and ST3Gal IV expression was negatively associated with the pathological grade of cervical cancer. " 01/01/2020 - "These results indicate that expression of ST3Gal IV is reduced in cervical cancer and plays a negative role in cell proliferation via Notch/p21/CDKs signaling pathway. " 01/01/2020 - "ST3Gal IV upregulation inhibited the growth and proliferation of cervical cancer HeLa and SiHa cells in vitro and in vivo. " 01/01/2020 - "While the expression and functions of ST3Gal IV in cervical cancer are still poorly understood. " 01/01/2020 - "ST3Gal IV Mediates the Growth and Proliferation of Cervical Cancer Cells In Vitro and In Vivo Via the Notch/p21/CDKs Pathway."

Related Drugs and Biologics

1.	beta-Galactoside alpha-2,3-Sialyltransferase
2.	Sialyltransferases
3.	beta-D-Galactoside alpha 2-6-Sialyltransferase
4.	Sialyl Lewis X Antigen
5.	Polysaccharides (Glycans)
6.	Messenger RNA (mRNA)
7.	N-Acetylneuraminic Acid (Sialic Acid)
8.	Gangliosides
9.	RNA (Ribonucleic Acid)
10.	Fucosyltransferases

Related Therapies and Procedures

1.	Castration
2.	Therapeutics