Ascending Aorta Dissection

Also Known As:

Dissection, Ascending Aorta; Aorta Dissection, Ascending; Aortic Dissection, Ascending; Aortic Root Dissections; Ascending Aorta Dissections; Ascending Aortic Dissections; Dissection, Ascending Aortic; Root Dissection, Aortic; Aortic Root Dissection; Ascending Aortic Dissection; Dissection, Aortic Root

Networked: 138 relevant articles (2 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Aneurysm: 24506
    - Blood Vessel Dissection: 480
      - Aortic Dissection: 5412
        Thoracic Aorta Dissection: 247
        Ascending Aorta Dissection: 138
  - Aortic Diseases: 879
    - Acute Aortic Syndrome: 141
      - Aortic Dissection: 5412
        Thoracic Aorta Dissection: 247
        Ascending Aorta Dissection: 138

Related Diseases

1.	Aortic Dissection
2.	False Aneurysm (Pseudoaneurysm)
3.	Rupture
4.	Aneurysm (Aneurysms)
5.	Myocardial Infarction

Experts

1.	LeMaire, Scott A: 4 articles (01/2018 - 02/2009)
2.	Coselli, Joseph S: 4 articles (08/2015 - 02/2009)
3.	Preventza, Ourania: 3 articles (05/2022 - 03/2011)
4.	Jing, Zaiping: 3 articles (12/2019 - 11/2016)
5.	Roselli, Eric E: 2 articles (05/2022 - 01/2018)
6.	Bao, Junmin: 2 articles (12/2019 - 11/2016)
7.	Li, Zhenjiang: 2 articles (12/2019 - 11/2016)
8.	Zhao, Zhiqing: 2 articles (12/2019 - 11/2016)
9.	Zhou, Jian: 2 articles (12/2019 - 11/2016)
10.	Feng, Yan-Mei: 2 articles (12/2018 - 12/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ascending Aorta Dissection:

1.	Bio-glueIBA 10/04/2023 - "The aim of this study was to develop a method to quantify the peel force in an in vitro model simulating repair of ascending aortic dissections with tissue glue (Bioglue). "
2.	1,3,4,6- tetra- O- acetyl- 2- azido- 2- deoxyglucopyranose (TAAD)IBA 12/01/2022 - "The aim of this study was to determine whether specific three-dimensional aortic shape features, extracted via statistical shape analysis (SSA), correlate with the development of thoracic ascending aortic dissection (TAAD) risk and associated aortic hemodynamics. "
3.	Polyethylene Terephthalates (Polyethylene Terephthalate)IBA 09/01/2010 - "Eighty-three patients (median age, 58 years) with acute or subacute ascending aortic dissection underwent surgical repair with right axillary artery perfusion through an interposition Dacron graft. " 03/01/1992 - "A 60-year-old man having an acute ascending aortic dissection was successfully operated on with a resection of the dissecting aorta which was replaced with a Dacron graft. " 01/01/2023 - "We present a case of a 72-year-old-male with an ascending aortic anastomotic pseudoaneurysm following Dacron graft repair of an iatrogenic ascending aortic dissection that occurred during an open mitral valve repair, which was successfully treated with endovascular graft placement. " 09/01/2016 - "We present a case of hemolytic anemia due to kinking of previously implanted Dacron graft for ascending aorta dissection treated by surgery and replaced with new Dacron. "
4.	Proteins (Proteins, Gene)FDA Link 02/01/2014 - "Compared with the control group, both in acute and chronic ascending aortic dissection, elastic fiber fragments increased and the expression of fibulin-4 protein significantly decreased (P= 0.045 < 0.05). " 02/01/2014 - "In conclusion, in aortic wall of ascending aortic dissection, the expression of fibulin-4 protein decreased and the expression of fibulin-4 mRNA was abnormal. " 03/01/2010 - "In the vascular wall of ascending aortic dissections, alpha 1 antitrypsin protein amounts are reduced compared with healthy aortas. " 09/01/2013 - "Both PN-1 and plasminogen activator inhibitor-1 mRNA and proteins were overexpressed in medial tissue extracts and primary VSMC cultures from thoracic aneurysm of the ascending aorta compared with acute ascending aortic dissection and controls. "
5.	Messenger RNA (mRNA)IBA 02/01/2014 - "The increased amounts of elastic fiber fragments were negatively correlated with the expression of fibulin-4 mRNA in acute ascending aortic dissection. " 02/01/2014 - "The level of fibulin-4 mRNA decreased in acute ascending aortic dissection (P= 0.034 < 0.05), while it increased in chronic ascending aortic dissection (P=0.004 < 0.05). " 02/01/2014 - "In conclusion, in aortic wall of ascending aortic dissection, the expression of fibulin-4 protein decreased and the expression of fibulin-4 mRNA was abnormal. " 09/01/2013 - "Both PN-1 and plasminogen activator inhibitor-1 mRNA and proteins were overexpressed in medial tissue extracts and primary VSMC cultures from thoracic aneurysm of the ascending aorta compared with acute ascending aortic dissection and controls. "
6.	Contrast MediaIBA 12/01/1999 - "Transthoracic echocardiography combined with an echocardiographic contrast agent can be useful in detecting an ascending aortic dissection." 12/01/1999 - "We describe a case in which transthoracic echocardiography with an echocardiographic contrast agent provided diagnostic information regarding an acute ascending aortic dissection, delineating both the true and false lumens. " 02/01/1999 - "We report 2 cases of the use of an echo contrast agent in enhancing the diagnostic capability of transesophageal echocardiography in suspected ascending aortic dissection. "
7.	Cardioplegic SolutionsIBA 03/01/1980 - "Iatrogenic ascending aortic dissection following cannulation for arterial return and for infusion of cardioplegic solution: Prevention and repair." 05/01/1992 - "We experienced a patient in whom acute ascending aortic dissection appeared to develop at the site of injection of the cardioplegic solution during coronary artery bypass surgery. "
8.	Aggrecans (Aggrecan)IBA 01/01/2018 - "Fbn1mgR/mgR mice with ascending aortic dissection and/or rupture had dramatically increased aggrecan staining compared with mice without these complications. "
9.	Metalloproteases (Metalloproteinases)IBA 10/01/2011 - "A disintegrin and metalloproteases (ADAMs) may reveal differences between AA and ascending aortic dissection (AD). " 10/01/2011 - "A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection."
10.	DisintegrinsIBA 10/01/2011 - "A disintegrin and metalloproteases (ADAMs) may reveal differences between AA and ascending aortic dissection (AD). " 10/01/2011 - "A disintegrin and metalloprotease -8 and -15 and susceptibility for ascending aortic dissection."

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 10/01/2016 - "Secondary ascending aortic dissection was found in 1 case two years later, which was cured by hybrid procedure with cardiopulmonary bypass. " 05/01/2008 - "During the repair of acute ascending aortic dissection, malperfusion syndrome related to femoral artery cannulation has an acceptable incidence, and can be managed under appropriate intraoperative monitoring, particularly at the initiation of cardiopulmonary bypass." 01/01/2007 - "By creating a graft-to-graft anastomosis on the bench during cooling of the patient on cardiopulmonary bypass, we were able to shorten to 21 minutes the period of hypothermic circulatory arrest required during ascending aortic dissection repair. " 01/01/2006 - "After beginning cardiopulmonary bypass, a retrograde ascending aortic dissection associated with cerebral malperfusion was recognized. " 01/01/2000 - "Between June 1991 and February 1999, three patients suffered ascending aortic dissection as a complication of cardiopulmonary bypass operations with aortic cannulation at our hospital. "
2.	Transcatheter Aortic Valve Replacement 02/01/2019 - "Transcatheter aortic valve replacement through chronic ascending aortic dissection: efficacy of the distal flex system of the SAPIEN 3 transcatheter heart valve." 01/01/2023 - "Postprocedural ascending aortic dissection after transcatheter aortic valve implantation: a case report." 06/01/2019 - "The authors report a case of 85-year-old male undergoing transcatheter aortic valve replacement (TAVR), whose intraoperative transesophageal echocardiogram was concerning for ascending aortic dissection. " 08/01/2018 - "A narrow and calcified sinotubular junction (STJ) represents a risk for ascending aortic dissection after balloon-expandable transcatheter aortic valve implantation (TAVI). " 07/01/2018 - "Successful Transcatheter Aortic Valve Replacement Using Balloon-Expandable Valve for Pure Native Aortic Valve Regurgitation in the Presence of Ascending Aortic Dissection."
3.	Stents 02/01/2008 - "The longitudinal length of the created ascending aortic dissection was 1.8 +/- 0.39 cm. Ultrasound studies revealed successful deployment of the stent graft and closure of the false lumen in all 12 cases. " 02/01/2008 - "This study assessed the feasibility of stent graft treatment of ascending aortic dissections in a porcine in vitro model. " 08/01/2023 - "Results from the ARISE early feasibility study of a specific ascending stent graft device to treat ascending aortic dissection are promising." 08/01/2023 - "ARISE: First-In-Human Evaluation of a Novel Stent Graft to Treat Ascending Aortic Dissection." 02/16/2022 - "We performed a novel hybrid transcarotid covered stent exclusion of a postoperative ascending aortic dissection in an infant. "
4.	Therapeutics 12/01/2019 - "The aim of this study was to summarize the published data linking endovascular therapy for ascending aortic dissection. " 01/01/2018 - "We represent a case of asymptomatic isolated chronic ascending aortic dissection that lasted for 15 years in which a patient was only followed up with medical therapy that saved him from early surgical intervention." 04/01/1999 - "Selected patients with acute type A (ascending) aortic dissection who are treated with delayed operation or nonoperative therapy may have better early and short-term outcomes than was previously expected. " 02/01/1983 - "Early diagnosis of the intraoperative or postoperative ascending aortic dissection process is essential to minimize the extent of dissection and prevent delay of definitive surgical therapy. " 02/01/2009 - "The treatment strategy of this condition is in part influenced by the location and the severity of aortic dissection as immediate surgical intervention is necessary in acute ascending aortic dissection, whereas medical therapy is the initial treatment approach in uncomplicated descending aortic dissection. "
5.	Cardiac Surgical Procedures 02/01/1983 - "This study retrospectively reviews the hospital records of 24 patients who developed ascending aortic dissection during or following 6,943 cardiac surgical procedures performed from January, 1971, through December, 1981. "