Thoracic Aorta Dissection

Dissection or a tear of the THORACIC AORTA. It includes aortic root dissection, ascending aortic dissection, aortic arch dissection and descending thoracic aortic dissection.

Also Known As:

Dissection, Thoracic Aorta; Aorta Dissection, Descending; Aorta Dissection, Thoracic; Aortic Arch Dissections; Aortic Dissection, Thoracic; Arch Dissection, Aortic; Descending Aorta Dissections; Dissection, Thoracic Aortic; Dissections, Aortic Arch; Thoracic Aorta Dissections; Thoracic Aortic Dissections; Aortic Arch Dissection; Descending Aorta Dissection; Descending Thoracic Aortic Dissection; Dissection, Aortic Arch; Dissection, Descending Aorta; Dissection, Descending Thoracic Aorta; Thoracic Aortic Dissection

Networked: 247 relevant articles (5 outcomes, 18 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Aneurysm: 24506
    - Blood Vessel Dissection: 480
      - Aortic Dissection: 5412
        Thoracic Aorta Dissection: 247
        Ascending Aorta Dissection: 138
  - Aortic Diseases: 879
    - Acute Aortic Syndrome: 141
      - Aortic Dissection: 5412
        Thoracic Aorta Dissection: 247
        Ascending Aorta Dissection: 138

Related Diseases

1.	Aneurysm (Aneurysms)
2.	Cardiovascular Diseases (Cardiovascular Disease)
3.	Thoracic Aortic Aneurysm
4.	Aortic Dissection
5.	Endoleak

Experts

1.	Du, Jie: 8 articles (12/2020 - 01/2016)
2.	LeMaire, Scott A: 8 articles (01/2018 - 08/2005)
3.	Zhang, Lei: 7 articles (08/2021 - 11/2010)
4.	Jing, Zaiping: 6 articles (06/2022 - 07/2008)
5.	Coselli, Joseph S: 6 articles (06/2014 - 08/2005)
6.	Shen, Ying H: 5 articles (06/2014 - 08/2005)
7.	Feng, Rui: 4 articles (06/2022 - 12/2007)
8.	Shu, Chang: 4 articles (04/2022 - 01/2017)
9.	Fu, Weiguo: 4 articles (01/2022 - 12/2012)
10.	Wang, Lixin: 4 articles (01/2022 - 12/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thoracic Aorta Dissection:

1.	Long Noncoding RNAIBA 01/01/2021 - "Construction and Integrated Analysis of Competitive Endogenous Long Non-Coding RNA Network in Thoracic Aortic Dissection." 01/01/2018 - "LncRNA Expression Profile of Human Thoracic Aortic Dissection by High-Throughput Sequencing." 11/01/2020 - "In the present study, the role and molecular mechanism of long noncoding RNA CDKN2B-AS1 in human thoracic aortic dissection (TAD), a highly lethal cardiovascular disease, was investigated. " 01/01/2018 - "In this study, the long non-coding RNA (lncRNA) expression profile in human thoracic aortic dissection (TAD), a highly lethal cardiovascular disease, was investigated. " 09/01/2018 - "LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human thoracic aortic dissection."
2.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "More importantly, the expression of C/EBPβ, MMP2/MMP9, and apoptosis-promoting proteins was increased in the aorta of human patients with thoracic aortic dissection, suggesting that the mechanisms identified in animal study could be relevant to human disease. " 11/01/2010 - "This study was to investigate the expression of these cytoskeleton proteins and their possible molecular pathway in the remodeling process of thoracic aortic dissection. " 02/01/2011 - "To investigate the potential role of four and a half Lin-11, Isl-1, and Mec-3 (FHL1) protein in the pathogenesis of thoracic aortic dissection (TAD). " 07/01/2008 - "Our results indicate that protein expression profiles in the aortic media from thoracic aortic dissection differ significantly from that of controls, which may provide important insights into the disease mechanisms. " 03/01/2015 - "To identify differentially expressed proteins from the aortic tissue of thoracic aortic dissection (TAD) with hypertension and normal aorta and to explore the potential molecular pathogenesis of TAD. "
3.	Messenger RNA (mRNA)IBA 01/01/2019 - "To assess the mRNA expression profile and explore the hub mRNAs and potential molecular mechanisms in the pathogenesis of human thoracic aortic dissection (TAD). " 09/01/2018 - "LncRNA and mRNA interaction study based on transcriptome profiles reveals potential core genes in the pathogenesis of human thoracic aortic dissection." 07/01/2013 - "We also observed increased aortic Th17 infiltration and IL-17 mRNA expression in patients with thoracic aortic dissections. " 01/01/2017 - "Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure the expression of BRM and MMP2 mRNA in the thoracic aortic aneurysm, thoracic aortic dissection, and normal tissues. " 01/01/2021 - "Through the statistical analysis, we determined the proportion of glycosylated hemoglobin (HbA1c) abnormalities (HbA1c > 5.7) in people with acute thoracic aortic dissection (ATAD) and compared the difference of messenger RNA (mRNA) and protein expression of GluT1 in the thoracic aorta of normal people and those with ATAD to find evidence that IR is a causative factor in AD. "
4.	fibrin fragment D (D-dimer)IBA 07/01/2013 - "The objective of this study is to determine at what probability of thoracic aortic dissection (TAD) to use a computed tomographic angiography (CTA) or a d-dimer test. " 11/01/2011 - "D-Dimer (DD) has been described as a useful predictor of both morphologic changes in acute thoracic aortic dissection (TAD) and of TAD-associated mortality. " 12/01/2007 - "A short cut review was carried out to establish whether a raised D-dimer could be used to identify patients with an acute thoracic aortic dissection. " 12/01/2007 - "Detection of acute thoracic aortic dissection with D-dimer." 05/01/2003 - "In addition, we investigated 14 patients who had received a confirmed diagnosis of thoracic aortic dissection during the previous 5 years, in whom d-dimer testing had been performed for differential diagnosis. "
5.	AminopropionitrileIBA 08/01/2020 - "Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models." 08/14/2019 - "Involvement of B cells in the pathophysiology of β-aminopropionitrile-induced thoracic aortic dissection in mice." 01/01/2016 - "β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice." 10/01/2013 - "This study compared three β-aminopropionitrile (BAPN) treatment rats to find the optimal BAPN model for thoracic aortic dissection and aneurysm in one study. " 06/01/2020 - "Intermittent Hypoxia Alleviates β-Aminopropionitrile Monofumarate Induced Thoracic Aortic Dissection in C57BL/6 Mice."
6.	S(8)IBA 10/01/2003 - "Twelve patient's (8%) AAAs were diagnosed with the initial CT study of their thoracic aortic dissection. " 12/20/2007 - "Simultaneous multi-tear exclusion: an optimal strategy for type B thoracic aortic dissection initially proved by a single center's 8 years experience."
7.	Destrin (Actin Depolymerizing Factor)IBA 11/01/2010 - "A study of the expression and interaction of Destrin, cofilin, and LIMK in Debakey I type thoracic aortic dissection tissue."
8.	Actin Depolymerizing Factors (Cofilins)IBA 11/01/2010 - "A study of the expression and interaction of Destrin, cofilin, and LIMK in Debakey I type thoracic aortic dissection tissue." 11/01/2010 - "Changes in the expression of cytoskeletal regulatory proteins such as LIMK and cofilin may play a role in weakening thoracic aortic medial tissue, as a precondition to thoracic aortic dissection." 11/01/2010 - "Western blotting showed that the protein expression of cofilin and LIMK was significantly decreased in thoracic aortic dissection tissue compared with normal control, (p = 0.004 for cofilin, p < 0.001 for LIMK). " 11/01/2010 - "The mRNA levels of cofilin and LIMK were lower in thoracic aortic dissection than normal control and were coincident with the protein expression (p = 0.0039 for cofilin, p = 0.017 for LIMK). "
9.	Interleukin-11 (Interleukin 11)IBA 06/01/2018 - "This study aimed to investigate whether IL-11 is involved in acute thoracic aortic dissection (TAD). " 06/01/2018 - "Increased interleukin-11 levels in thoracic aorta and plasma from patients with acute thoracic aortic dissection."
10.	Matrix Metalloproteinases (MMPs)IBA 10/01/2014 - "Thoracic aortic dissection (TAD) is a life-threatening vascular condition, in which matrix metalloproteinases (MMPs) are involved. " 06/15/2014 - "Matrix metalloproteinase levels in chronic thoracic aortic dissection." 10/01/2010 - "The relationship between elastolytic matrix metalloproteinases (MMPs) (such as MMP-2, MMP-9) and thoracic aortic dissection (TAD) has been described, but little is known regarding the role of collagenolytic MMPs in thoracic aortic dissection. " 05/01/2009 - "This article reviews the recent literature and summarizes our current understanding of the role of MMPs in the pathobiology of thoracic aortic dissection. " 05/01/2009 - "Thoracic aortic dissection: are matrix metalloproteinases involved?"

Therapies and Procedures

1.	Stents 03/01/2011 - "Spontaneous acute stanford type B thoracic aortic dissection treated successfully with endovascular stent graft." 10/01/2019 - "Conclusion: The use of homemade fenestrated stent-grafts for endovascular repair of aortic arch dissections is feasible and effective for total endovascular aortic arch repair. " 04/01/2023 - "The outcomes obtained during 12 months of follow-up suggested that performing endovascular repair for thoracic aortic dissection patients with a partial micropore stent graft is safe and effective, maintaining the patency of aortic arch branch vessels." 03/01/2011 - "The modified total aortic arch replacement and stent elephant trunk technique treatment for patients with DeBakey I thoracic aortic dissection was safe and effective, with less postoperative complications." 12/01/2002 - "Endovascular stent-graft implantation in descending thoracic aortic dissection is a feasible, safe, and effective treatment modality. "
2.	Endovascular Aneurysm Repair 05/01/2019 - "The purpose of this study was to compare perioperative and mortality outcomes of endovascular aortic repair against open repair in acute type B thoracic aortic dissection. " 01/01/2018 - "The aim of this study was to investigate thoracic endovascular aortic repair (TEVAR) outcomes in patients with confirmed or suspected syndromic and nonsyndromic genetically triggered thoracic aortic dissection. " 06/10/2023 - "Description of thoracic aortic dissection helical morphology and dynamics, and understanding the impact of thoracic endovascular aortic repair (TEVAR) on dissection helicity, are important for improving endovascular treatment. " 04/01/2023 - "Early Thoracic Endovascular Aortic Repair of Uncomplicated Type B Thoracic Aortic Dissection: An Aorta Team Approach." 01/01/2022 - "Positive remodeling after thoracic endovascular aortic repair (TEVAR) for chronic thoracic aortic dissection is variable due to incomplete distal seal and retrograde false lumen perfusion. "
3.	Thoracotomy 01/01/2018 - "The study objective was to analyze clinical outcomes, distal segmental aortic growth, and aortic reoperation rates after 1-stage open repair of extensive chronic thoracic aortic dissection via bilateral anterior thoracotomy. " 02/01/2011 - "Pull-through technique for entire thoracic aortic dissection without additional left thoracotomy." 02/20/2018 - "This tutorial illustrates the technique of single-stage thoracic aorta replacement and aortic valve replacement via a clamshell thoracotomy in acute aortic arch dissection with proximal aneurysms of the left subclavian artery and an aberrant right subclavian artery. " 11/01/2008 - "Fifty-one patients with chronic expanding thoracic aortic dissections (48 type A, 3 type B with proximal extension) were treated with a single procedure using a bilateral anterior thoracotomy, hypothermic circulatory arrest, and reperfusion of the arch vessels first to minimize brain ischemia. " 01/01/1991 - "This report presents the case of a 55-year-old male with rupture of a descending thoracic aortic dissection into the right hemithorax who successfully underwent prosthetic graft replacement of the involved segment of the aorta through left thoracotomy."
4.	Resuscitation 10/01/2018 - "Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections: The VIPER-OCTA Randomized Clinical Pilot Trial."
5.	Mechanical Ventilators (Ventilator) 10/01/2018 - "In this randomized, clinical pilot trial of patients undergoing emergency surgery for thoracic aorta dissections, we found that OctaplasLG reduced glycocalyx and endothelial injury, reduced bleeding, transfusions, use of prohemostatics, and time on ventilator after surgery compared to standard FFP. "