Dental Enamel Hypomineralization

Reduced mineralization disorder of the DENTAL ENAMEL during development resulting in qualitative defects, e.g., discolored or chalky (soft) enamel.

Also Known As:

Dental Enamel Hypomineralizations; Dental Hypomineralizations; Enamel Hypomineralizations; Hypocalcification, Enamel; Hypomineralization, Dental; Hypomineralization, Dental Enamel; Hypomineralization, Enamel; Tooth Hypomineralizations; Dental Hypomineralization; Enamel Hypocalcification; Enamel Hypomineralization; Enamel Hypomineralization, Dental; Hypocalcification of Enamel; Hypomineralization of Enamel of Tooth; Hypomineralization, Tooth; Tooth Hypomineralization

Networked: 35 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Molar Hypomineralization
2.	Wounds and Injuries (Trauma)
3.	Trismus (Lockjaw)
4.	Seizures (Absence Seizure)
5.	Rickets (Rachitis)

Experts

1.	Babajko, Sylvie: 3 articles (11/2016 - 08/2014)
2.	Berdal, Ariane: 3 articles (11/2016 - 08/2014)
3.	Jedeon, Katia: 3 articles (11/2016 - 08/2014)
4.	Loiodice, Sophia: 3 articles (11/2016 - 08/2014)
5.	Millán, José Luis: 2 articles (01/2021 - 08/2012)
6.	Manton, D J: 2 articles (01/2018 - 09/2007)
7.	Houari, Sophia: 2 articles (11/2016 - 01/2016)
8.	Alaluusua, Satu: 2 articles (09/2013 - 01/2006)
9.	Cantio, Emily: 1 article (01/2022)
10.	Christesen, Henrik Thybo: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Dental Enamel Hypomineralization:

1.	FluoridesIBA 05/04/2023 - "TGF-β1/Smad3 Signaling Is Required to Alleviate Fluoride-Induced Enamel Hypomineralization." 03/01/2004 - "This enamel hypomineralization was attributed to a fluoride-induced impairment of the process of enamel maturation. " 10/01/1997 - "The marked variation in the severity of enamel hypomineralization seen along the coronocervical axis of a specimen pointed to a fluoride impact of varying intensity during this period of tooth development. " 10/01/1986 - "This finding is unlikely to be a result of different fluoride exposures in the two age groups and indicates that even several years after eruption there is a trend towards an increasing severity of enamel surface destructions in children exhibiting pronounced degrees of subsurface enamel hypomineralization at time of eruption." 09/01/2007 - "Dental fluorosis is a condition of enamel hypomineralization due to the effects of excessive fluoride on ameloblasts during enamel formation. "
2.	Proteins (Proteins, Gene)FDA Link 01/01/2002 - "In the light of evidence obtained in human and animal studies, it is now most likely that enamel hypomineralization in fluorotic teeth is due predominantly to the aberrant effects of excess fluoride on the rates at which matrix proteins break down and/or the rates at which the by-products from this degradation are withdrawn from the maturing enamel. " 01/01/2018 - "Nkcc1-null mice are associated with enamel hypomineralization and increased expression of GJ protein connexin 43 (Cx43), suggesting that reduced ion transport in the Nkcc1-null mouse is in part compensated by increased intercellular ion transport through GJs. "
3.	Penicillins (Penicillin)FDA Link 03/01/2014 - "This study concludes that frequent use of antibiotics such as penicillins and cephalosporins has positive association with enamel hypomineralization in developing tooth structure."
4.	Cephalosporins (Cephalosporin Antibiotics)IBA 03/01/2014 - "This study concludes that frequent use of antibiotics such as penicillins and cephalosporins has positive association with enamel hypomineralization in developing tooth structure."
5.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2014 - "This study concludes that frequent use of antibiotics such as penicillins and cephalosporins has positive association with enamel hypomineralization in developing tooth structure."
6.	Amoxicillin (Wymox)FDA LinkGeneric 07/01/2020 - "The administration of amoxicillin in juvenile mice induced enamel hypomineralization, and the effects of amoxicillin on enamel hypomineralization may be mediated via multiple pathways." 07/01/2020 - "However, to the best of our knowledge, the role of amoxicillin in enamel hypomineralization has not yet been fully elucidated. " 01/01/2016 - "Amoxicillin used in early childhood may be associated with enamel hypomineralization. " 09/01/2013 - "It has also been suggested that amoxicillin use in early childhood is associated with enamel hypomineralization. " 01/01/2006 - "[Amoxicillin may be a cause of enamel hypomineralization]."
7.	Endocrine DisruptorsIBA 08/01/2014 - "Enamel hypomineralization due to endocrine disruptors." 11/01/2016 - "Endocrine-disrupting chemicals (EDCs) that interfere with the steroid axis can affect amelogenesis, leading to enamel hypomineralization similar to that of molar incisor hypomineralization, a recently described enamel disease. "
8.	Vitamin D FDA LinkGeneric 01/01/2022 - "Vitamin D status and tooth enamel hypomineralization are not associated in 4-y-old children: An Odense Child Cohort study." 01/01/2018 - "Foetal, neonatal and child vitamin D status and enamel hypomineralization."
9.	Alkaline PhosphataseIBA 08/01/2012 - "Mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene can result in skeletal and dental hypomineralization and severe neurological symptoms. " 01/01/2023 - "Hypophosphatasia (HPP), caused by loss-of-function mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life-threatening to milder manifestations only in adulthood. "
10.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/01/2021 - "Skeletal and dental hypomineralization characterizes HPP, with disease severity varying from life-threatening perinatal or infantile forms to milder forms that manifest in adulthood or only affect the dentition. " 01/01/2023 - "Hypophosphatasia (HPP), caused by loss-of-function mutations in the ALPL gene encoding tissue-nonspecific alkaline phosphatase (TNAP), is characterized by skeletal and dental hypomineralization that can vary in severity from life-threatening to milder manifestations only in adulthood. "

Therapies and Procedures

1.	Transjugular Intrahepatic Portasystemic Shunt 11/01/2011 - "Clinical tips for porcelain veneer cases with enamel hypocalcification."
2.	Tooth Bleaching 03/01/2021 - "Thus, the present clinical case aimed to present an aesthetic treatment of enamel hypomineralization in the upper incisors with a minimally invasive approach of association of microabrasion with low concentration tooth whitening photoaccelerated by violet LED and infrared laser. "
3.	Therapeutics 01/01/2021 - "Dental findings at follow-up after completion of NB therapy included hypodontia, hypocalcification of enamel, and trismus. "
4.	Lasers (Laser) 03/01/2021 - "Thus, the present clinical case aimed to present an aesthetic treatment of enamel hypomineralization in the upper incisors with a minimally invasive approach of association of microabrasion with low concentration tooth whitening photoaccelerated by violet LED and infrared laser. "
5.	Oral Diagnosis (Oral Examination) 06/01/2013 - "During the dental examination, oral hygiene, non-cavitated and cavitated caries lesions, dental trauma, and enamel hypomineralization (EH) in the permanent dentition (MIH/1) were recorded. "