Developmental Defects of Enamel

Defects in normal AMELOGENESIS caused by any local, systemic, environmental, or genetic factors. Enamel defects resulting from demineralization of normally developed DENTAL ENAMEL is referred to as TOOTH DEMINERALIZATION.

Also Known As:

Networked: 166 relevant articles (1 outcomes, 33 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dental Caries (Decay, Dental)
2.	Birth Weight (Birth Weights)
3.	Asthma (Bronchial Asthma)
4.	Anodontia (Hypodontia)
5.	Chronic Renal Insufficiency

Experts

1.	Corrêa-Faria, Patrícia: 8 articles (03/2019 - 05/2013)
2.	Paiva, Saul Martins: 5 articles (01/2019 - 08/2013)
3.	Wong, Hai Ming: 5 articles (06/2016 - 12/2005)
4.	Ramos-Jorge, Maria Letícia: 4 articles (09/2022 - 07/2013)
5.	McGrath, Colman: 4 articles (05/2019 - 12/2005)
6.	Golkari, Ali: 4 articles (01/2016 - 04/2011)
7.	King, Nigel M: 4 articles (01/2015 - 12/2005)
8.	Jan, J: 3 articles (06/2022 - 11/2000)
9.	Paixão-Gonçalves, Suzane: 3 articles (01/2019 - 03/2015)
10.	Pordeus, Isabela Almeida: 3 articles (01/2019 - 08/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Developmental Defects of Enamel:

1.	FluoridesIBA 02/01/1990 - "We believe a more critical approach to the diagnosis of fluorosis will be helpful in the rational use and control of fluorides for dental health, and in the identification of factors associated with inducing developmental defects of enamel." 05/01/2011 - "In a low-fluoride community, developmental defects of enamel were twice as common in the permanent dentition vs the primary dentition. " 01/01/2006 - "Association between developmental defects of enamel and different concentrations of fluoride in the public water supply." 02/12/2000 - "Prevalence of caries and developmental defects of enamel in 9-10 year old children living in areas in Brazil with differing water fluoride histories." 04/01/1994 - "Prevalence of developmental defects of enamel in areas with differing water fluoride levels and socio-economic groups in Sri Lanka and England."
2.	Dichlorodiphenyl Dichloroethylene (DDE)IBA 07/15/2023 - "Purpose: The purpose of this study was to find potential risk factors associated with the occurrence of developmental defects of enamel (DDE) in permanent dentition of a birth cohort in Southern Brazil. " 01/01/2022 - "This study aimed to systematically analyze the relationship between preterm (PT), low birth weight (LBW), and developmental defects of enamel (DDE) in the primary dentition. " 11/01/2021 - "The study population (n = 57; mean age 11.5 years, range 2-27 years) experienced a range of medical conditions involving multiple medical systems; of whom 44 (77.2%) had caries experience, 7 (12.3%) developmentally missing teeth, and 31 (54.4%) developmental defects of enamel (DDE). " 01/01/2021 - "This study investigates the influence of early childhood caries (ECC) on the occurence of developmental defects of enamel (DDE) on permanent teeth. " 10/01/2019 - "To evaluate the ability to recognise different types of developmental defects of enamel (DDE) by a group of general dental staff, trained prior to the comprehensive prevalence study (the BITA study), and to compare their skills to that of an untrained group. "
3.	Drinking WaterIBA 11/01/2002 - "The study was conducted to assess caries and developmental defects of enamel in relation to fluoride levels in drinking water and the association between caries experience and the severity of diffuse opacities in children living in Uda Walawe, an area with varying concentrations of fluoride in drinking water in Sri Lanka. " 01/01/2016 - "The inconsistent prevalence of fluorosis for a given level of fluoride in drinking water suggests developmental defects of enamel (DDEs) other than fluorosis were being misdiagnosed as fluorosis. " 05/01/2011 - "Developmental defects of enamel in children of Davangere District and their relationship to fluoride levels in drinking water." 08/01/2003 - "To assess the prevalence and distribution of developmental defects of enamel and caries in 14-year-old children who had been lifetime residents in a region with different concentrations of fluoride in drinking water in Sri Lanka. " 12/01/1994 - "The variation in the prevalence of developmental defects of enamel in areas of North Wales with low levels of fluoride in the drinking water was studied. "
4.	Growth Hormone (Somatotropin)IBA 01/01/2023 - "The aim of the study was to evaluate the occurrence of dental anomalies: microdontia, macrodontia, hypodontia and developmental defects of enamel (DDE) amongst a group of isolated growth hormone deficient (GHD) patients and healthy children. " 01/01/2019 - "Oestrogen (ES) and growth hormone (GH) are hormones that may have a role in caries aetiology and developmental defects of enamel (DDE) since their receptors (ERs and GHR) are expressed during amelogenesis. "
5.	Vitamin DFDA LinkGeneric 10/20/2022 - "The inclusion criteria were randomised controlled trials and cohort studies published between June 16, 2017 and June 16, 2022, laboratory assessment of prenatal vitamin D status and evaluation of primary or mixed dentition for observation of dental caries and developmental defects of enamel. "
6.	Penicillins (Penicillin)FDA Link 03/01/2014 - "Our objective of the study was to determine the association between frequent use of Penicillins and Cephalosporins with developmental defects of enamel in pediatric age group. "
7.	Cephalosporins (Cephalosporin Antibiotics)IBA 03/01/2014 - "Our objective of the study was to determine the association between frequent use of Penicillins and Cephalosporins with developmental defects of enamel in pediatric age group. "
8.	Tenofovir (Viread)FDA Link 11/01/2020 - "As a comparative method to study bone density, we investigated the influence of in utero tenofovir exposure on the prevalence and distribution of developmental defects of enamel (DDE) in the primary dentition, as the mineralization process in teeth is higher and more complex and thus more vulnerable. " 11/01/2020 - "What is Known: • There are no data available on the prevalence of developmental defects of enamel (DDE) in the primary dentition in intrauterine HIV- and tenofovir-exposed children. "
9.	SugarsIBA 11/01/2009 - "Frequency of sugar consumption, enamel developmental defects, social factors such as socioeconomic status, psychosocial factors, and being an ethnic minority also have shown to be relevant in determining caries risk. " 05/01/2007 - "The results of logistic regression analysis showed that the factors associated with high dmft were developmental defect of enamel, visible plaque index, frequency of toothbrushing, frequency of sugar consumption, and income. " 05/01/2007 - "Advocating brushing teeth at least twice daily, controlling the frequency of sugar consuming, reducing the developmental defect of enamel and paying more attention to the oral health of lower income population may effectively reduce dental caries of the children." 01/01/2015 - "Various risk factors for dental caries like type of oral hygiene practice, sugar exposures/day, developmental defects of enamel, caries activity, salivary streptococci mutans levels and lactobacilli levels were evaluated and compared among the three groups of children. " 05/01/2019 - "Early childhood caries is related to frequent sugar consumption in an environment of enamel adherent, acid-producing bacteria in a complex biofilm, as well as developmental defects of enamel. "
10.	Indicators and Reagents (Reagents)IBA 11/01/2006 - "LEH, a developmental defect of enamel, is a sensitive indicator of systemic physiological stress (Goodman and Rose [1990] Yrbk. " 04/01/2003 - "LEH is a developmental defect of enamel that is used in many anthropological contexts as a physiological stress indicator. "

Therapies and Procedures

1.	Oral Hygiene (Dental Hygiene) 11/16/2022 - "Dental and Dental Hygiene Students' Knowledge and Capacity to Discriminate the Developmental Defects of Enamel: A Self-Submitted Questionnaire Survey." 05/14/2013 - "Children with low birth weight show an increased prevalence of developmental defects of enamel in the primary dentition that subsequently may predispose to early childhood caries (ECC).Focusing 6-36 months old, the purpose of this study was to assess the frequency of enamel defects in the primary dentition and identify influences of early life course factors; socio-demographics, birth weight, child's early illness episodes and mothers' perceived size of the child at birth, whilst controlling for more recent life course events in terms of current breastfeeding and oral hygiene. " 05/01/2019 - "Clinical examinations checked dental caries using the dmft/DMFT index, dental hygiene using the Simplified Greene-Vermillion Index (DI-S), gingival inflammation using the Community Periodontal Index of Treatment Needs, and enamel defects using the modified Developmental Defects of Enamel Index. " 09/01/2017 - "Mothers completed the Antonovsky's SOC instrument (SOC-13) and their children's oral cavity had been examined for developmental defects of enamel (DDE), occlusal problems, dental caries (DMFT/dmft) and oral hygiene. " 01/01/2015 - "Various risk factors for dental caries like type of oral hygiene practice, sugar exposures/day, developmental defects of enamel, caries activity, salivary streptococci mutans levels and lactobacilli levels were evaluated and compared among the three groups of children. "
2.	Dental Care 06/01/2018 - "The prevalence of developmental defects of enamel, a prospective cohort study of adolescents in Western Sweden: a Barn I TAnadvarden (BITA, children in dental care) study."
3.	Oral Diagnosis (Oral Examination) 12/01/2004 - "The data were collected through a self-administered questionnaire survey and an oral examination, using the Modified Developmental Defects of Enamel Index (FDI, 1992). " 08/01/2013 - "Oral examinations of the children were performed by a single, previously calibrated examiner for the assessment of dental caries experience, malocclusion, traumatic dental injury and developmental defects of enamel. " 01/01/2020 - "Thereafter, a single, adequately trained dentist carried out children's oral examinations for gingival inflammation (Silness-Löe index), dental plaque (Green-Vermillion Simplified index), dental caries (dmft index), developmental defects of enamel (DDE index), tooth discoloration, oral mucosal/lip alterations. "
4.	Tertiary Prevention 10/26/2023 - "In this review, we generalize the research progress of environmental factors affecting enamel developmental defects, summarize the potential mechanisms of environmental factors leading to enamel developmental defects, and conclude the clinical management strategies based on tertiary prevention. "
5.	Toothbrushing 05/01/2007 - "The results of logistic regression analysis showed that the factors associated with high dmft were developmental defect of enamel, visible plaque index, frequency of toothbrushing, frequency of sugar consumption, and income. "