Polypoidal Choroidal Vasculopathy

A CHOROID neovascularization characterized by serosanguineous retinal pigment epithelial detachment and leakage of serous exudate sometimes associated with aneurysmal polypoidal lesions.

Also Known As:

CNV, Polypoidal; Choroidal Neovascularization, Polypoidal; Choroidal Neovascularizations, Polypoidal; Choroidal Vasculopathies, Polypoidal; Choroidal Vasculopathy, Polypoidal; Neovascularization, Polypoidal Choroidal; Polypoidal CNVs; Polypoidal Choroidal Neovascularizations; Polypoidal Choroidal Vasculopathies; Vasculopathy, Polypoidal Choroidal; Idiopathic Polypoidal Choroidal Vasculopathy; Polypoidal CNV; Polypoidal Choroidal Neovascularization

Networked: 896 relevant articles (96 outcomes, 126 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Macular Degeneration (Age-Related Maculopathy)
2.	Polyps
3.	Choroidal Neovascularization
4.	Hemorrhage
5.	Retinal Detachment (Retinal Detachments)

Experts

1.	Tsujikawa, Akitaka: 37 articles (06/2022 - 05/2006)
2.	Yoshimura, Nagahisa: 36 articles (03/2018 - 05/2002)
3.	Yamashiro, Kenji: 30 articles (06/2022 - 09/2007)
4.	Iida, Tomohiro: 30 articles (01/2022 - 08/2002)
5.	Sakurada, Yoichi: 28 articles (09/2021 - 11/2009)
6.	Cheung, Chui Ming Gemmy: 27 articles (12/2022 - 08/2014)
7.	Honda, Shigeru: 27 articles (12/2020 - 10/2007)
8.	Kim, Jong Woo: 26 articles (10/2022 - 04/2012)
9.	Kim, Chul Gu: 24 articles (10/2022 - 04/2012)
10.	Lee, Won Ki: 23 articles (01/2022 - 03/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Polypoidal Choroidal Vasculopathy:

1.	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/01/2008 - "In this patient with tilted disk syndrome, unilateral polypoidal choroidal vasculopathy was diagnosed by ICG angiography and treated successfully with PDT." 06/01/2022 - "The logMAR VA change of 0.3 or more was defined as "improved" or "declined." Twenty-three consecutive eyes (typical AMD: 10 eyes, polypoidal choroidal vasculopathy: 10 eyes, and pachychoroid neovasculopathy: 3 eyes), which underwent "rescue-PDT," were analyzed in this study. " 01/01/2010 - "This prospective, nonrandomized, consecutive study included 80 eyes of 80 patients with polypoidal choroidal vasculopathy who underwent an initial PDT. " 01/01/2021 - "Forty-one eyes (39 patients) with polypoidal choroidal vasculopathy (PCV) and 32 eyes (31 patients) with typical AMD (tAMD) who underwent PDT were retrospectively investigated. " 01/01/2021 - "Using en face optical coherence tomography images, we analyzed vascular density of the area outside the polypoidal choroidal vasculopathy lesion and within the PDT exposure area at the level of the choriocapillaris and middle layer of the choroid. "
2.	Ranibizumab (Lucentis)FDA Link 07/01/2013 - "To evaluate the efficacy of intravitreal ranibizumab (IVR) for subfoveal polypoidal choroidal vasculopathy (PCV) in eyes with a best corrected visual acuity (BCVA) of 0.6 (logMAR 0.22) or better. " 11/01/2015 - "To determine safety and efficacy of intravitreal high-dose ranibizumab in the treatment of active neovascular polypoidal choroidal vasculopathy (PCV). " 09/01/2011 - "Intravitreal ranibizumab is an effective treatment for maintaining or improving visual acuity and the anatomical changes in patients with polypoidal choroidal vasculopathy with recurrent or residual exudation from branching vascular network vessels." 03/01/2017 - "To investigate the efficacy of a treat-and-extend regimen (TER) using ranibizumab to treat polypoidal choroidal vasculopathy (PCV). " 01/01/2013 - "To determine safety, tolerability, and efficacy of intravitreal ranibizumab in the treatment of polypoidal choroidal vasculopathy in a non-Asian population. "
3.	afliberceptIBA 01/01/2021 - "To evaluate the one-year efficacy of intravitreal aflibercept injection in polypoidal choroidal vasculopathy (PCV) with best-corrected visual acuity (BCVA) of 20 / 40 or better. " 01/01/2015 - "Results of landmark clinical investigations, including VIEW 1 and 2 trials, and other important studies are then summarized and used to illustrate the efficacy of aflibercept for managing treatment-naïve CNV, recalcitrant CNV, and CNV due to polypoidal choroidal vasculopathy. " 10/01/2018 - "Intravitreal aflibercept was effective in improving the vision of patients with polypoidal choroidal vasculopathy, as evaluated at the 3-year follow-up. " 01/01/2016 - "Aflibercept is effective for the eyes with treatment-naive polypoidal choroidal vasculopathy to achieve the resolution of polypoidal lesions. " 01/01/2022 - "Efficacy of a novel personalised aflibercept monotherapy regimen based on polypoidal lesion closure in participants with polypoidal choroidal vasculopathy."
4.	Verteporfin (Visudyne)FDA Link 09/01/2010 - "The purpose of this study was to evaluate the efficacy of verteporfin photodynamic therapy on the treatment of polypoidal choroidal vasculopathy. " 02/01/2012 - "To study the effects of photodynamic therapy using verteporfin in the treatment of patients with subfoveal polypoidal choroidal vasculopathy (PCV). " 10/01/2002 - "To study the effects of photodynamic therapy using verteporfin in the treatment of patients with subfoveal polypoidal choroidal vasculopathy (PCV). " 08/01/2015 - "To evaluate the 3-year outcome in eyes with polypoidal choroidal vasculopathy (PCV) treated with photodynamic therapy with verteporfin. " 09/01/2010 - "Photodynamic therapy with verteporfin in polypoidal choroidal vasculopathy: results after 3 years of follow-up."
5.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/01/2011 - "An aging population, the efficacy of anti-VEGF drugs and the relative rarity of polypoidal choroidal vasculopathy (PCV) in Europe are factors contributing to our proportional increase in AMD patients. " 06/01/2022 - "To investigate whether the efficacy of anti-vascular endothelial growth factor (VEGF) monotherapy for polypoidal choroidal vasculopathy (PCV) differs between pachychoroid and non-pachychoroid phenotypes in the long term. " 04/01/2021 - "Clinical characteristics of super stable polypoidal choroidal vasculopathy after initial remission with anti-VEGF monotherapy." 01/01/2019 - "This retrospective, single-institution study was performed with 221 patients who were diagnosed as having unilateral polypoidal choroidal vasculopathy and who were treated with intravitreal anti-vascular endothelial growth factor. " 03/01/2012 - "The aim of this study was to investigate whether polymorphisms in the vascular endothelial growth factor A gene (VEGF-A) are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and whether they are associated with PCV phenotypes. "
6.	Bevacizumab (Avastin)FDA Link 07/01/2010 - "To evaluate the efficacy of intravitreal bevacizumab (IVB) in eyes with polypoidal choroidal vasculopathy (PCV). " 01/01/2009 - "To evaluate the short-term safety and efficacy of a single intravitreal bevacizumab injection in patients with polypoidal choroidal vasculopathy (PCV). " 01/01/2009 - "Short-term safety and efficacy of a single intravitreal bevacizumab injection for the management of polypoidal choroidal vasculopathy." 01/01/2008 - "Efficacy of intravitreal bevacizumab for polypoidal choroidal vasculopathy." 11/22/2022 - "To investigate the features and treatment response in Caucasian patients with polypoidal choroidal vasculopathy (PCV), initially treated with bevacizumab. "
7.	Indocyanine Green (Cardio-Green)FDA LinkGeneric 07/24/2023 - "The gold standard for polypoidal choroidal vasculopathy (PCV) diagnosis is indocyanine green angiography (ICGA), but optical coherence tomography angiography (OCTA) has shown promise for PCV imaging in recent years. " 01/01/2021 - "This study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). " 01/01/2020 - "A Comparison Study of Polypoidal Choroidal Vasculopathy Imaged with Indocyanine Green Angiography and Swept-Source Optical Coherence Tomography Angiography." 01/01/2016 - "The purpose of this study was to compare the angiographic findings of polypoidal choroidal vasculopathy (PCV) detected by indocyanine green angiography (ICGA) and en face optical coherence tomography angiography (OCTA). " 06/02/2009 - "The original study did not consider findings of indocyanine green (ICG) angiography for disease classification, which is the only way to obtain a clear image of polypoidal choroidal vasculopathy (PCV) lesions. "
8.	KH902 fusion proteinIBA 05/01/2016 - "To evaluate the efficacy of different doses of conbercept in patients with polypoidal choroidal vasculopathy in the AURORA study. " 01/01/2020 - "The Efficacy of Conbercept in Polypoidal Choroidal Vasculopathy: A Systematic Review." 01/01/2018 - "Short-term efficacy of intravitreal conbercept in treatment-naive patients with polypoidal choroidal vasculopathy." 05/01/2023 - "The comparison of two different strategies of intravitreal conbercept for polypoidal choroidal vasculopathy in Chinese patients results from a 48-week randomized phase 4 study: STAR study." 05/01/2023 - "To compare a treat-and-extend (TAE) strategy with a fixed dosing regimen of intravitreal conbercept (IVC) for the management of treatment-naïve polypoidal choroidal vasculopathy (PCV) patients. "
9.	Retinaldehyde (Retinal)IBA 06/09/2023 - "It will exclude studies that include participants diagnosed with polypoidal choroidal vasculopathy or retinal angiomatous proliferation. " 01/28/2023 - "This study proposes a convolutional neural network (CNN)-based deep learning model for classifying the subtypes of nAMD (polypoidal choroidal vasculopathy, retinal angiomatous proliferation, and typical nAMD) and CSC (chronic CSC and acute CSC) and healthy individuals using single spectral-domain optical coherence tomography (SD-OCT) images. " 01/01/2021 - "The objective of this study was to compare visual parameters and retinal layers' morphology pre-treatment (baseline) and 6 months post-treatment in polypoidal choroidal vasculopathy (PCV) eyes. " 12/01/2015 - "This objective of this study was to compare the visibility of retinal and choroidal features in polypoidal choroidal vasculopathy (PCV) using SS-OCT and SD-OCT. " 09/01/2014 - "In the present study, we investigate the genetic and clinical factors associated with reticular pseudodrusen (RPD) in patients with exudative AMD, including polypoidal choroidal vasculopathy (PCV), typical neovascular AMD, and retinal angiomatous proliferation (RAP). "
10.	Triamcinolone Acetonide (Azmacort)FDA LinkGeneric 01/01/2017 - "To evaluate the efficacy and adverse effects of using low-dose intravitreal triamcinolone acetonide (IVTA) to preserve vision in polypoidal choroidal vasculopathy (PCV) eyes. " 01/01/2017 - "Vision Preservation in Eyes of Polypoidal Choroidal Vasculopathy with Low-Dose Intravitreal Triamcinolone Acetonide." 08/01/2005 - "To report a case of polypoidal choroidal vasculopathy (PCV) that was successfully treated by sub-Tenon's infusion of triamcinolone acetonide (TA). " 08/01/2005 - "Visual improvement following trans-Tenon's retrobulbar triamcinolone acetonide infusion for polypoidal choroidal vasculopathy." 02/01/2010 - "Photodynamic therapy with or without intravitreal triamcinolone acetonide for symptomatic polypoidal choroidal vasculopathy."

Therapies and Procedures

1.	Photochemotherapy (Photodynamic Therapy) 04/15/2020 - "Comparing efficacy of reduced-fluence and standard-fluence photodynamic therapy in the treatment of polypoidal choroidal vasculopathy." 12/01/2019 - "Efficacy of Photodynamic Therapy for Polypoidal Choroidal Vasculopathy Associated with and without Pachychoroid Phenotypes." 08/01/2015 - "The main outcome measures were best-corrected visual acuity, repeat photodynamic therapy, and recurrence of PCV at the end of Years 1, 2, and 3. We further conducted a systematic review of the literature using the terms "polypoidal choroidal vasculopathy" and "photodynamic therapy" and compared the visual outcome of studies over 3 years using meta-analytical methods. " 04/01/2012 - "The purpose of this study was to evaluate the macular function by measuring the focal macular electroretinograms (ERGs) recorded before and after reduced fluence photodynamic therapy (RFPDT) in patients with polypoidal choroidal vasculopathy (PCV). " 09/01/2010 - "A prospective, nonrandomized institutional study was conducted involving 42 eyes of 38 patients with newly diagnosed symptomatic polypoidal choroidal vasculopathy treated exclusively with photodynamic therapy. "
2.	Therapeutics 09/01/2021 - "Long-term prognosis of polypoidal choroidal vasculopathy with a 5-year remission after an initial combination therapy." 11/01/2021 - "Comparison of visual outcomes between therapy choices and subtypes of polypoidal choroidal vasculopathy (PCV) in Taiwan: a real-world study." 06/01/2010 - "This study included 29 treatment-naïve patients with polypoidal choroidal vasculopathy followed up for 12 months after the first combined therapy. " 01/01/2022 - "A total of 46 eyes from 46 patients who underwent the combination therapy for polypoidal choroidal vasculopathy were followed for more than 6 months. " 01/01/2022 - "Combination therapy or monotherapy for polypoidal choroidal vasculopathy (PCV) treatment"."
3.	Intravitreal Injections 10/01/2018 - "The SMHs were related to polypoidal choroidal vasculopathy (PCV) in 24 eyes and typical AMD in nine eyes and treated with intravitreal injection of SF6 gas with tPA. " 05/01/2021 - "However, the flow density in optical coherence tomography angiography image and the visual outcome did not reveal any significant difference before or after intravitreal injections, and neither were there significant differences between the neovascular age-related macular degeneration and polypoidal choroidal vasculopathy groups. " 05/01/2016 - "EFFICACY OF INTRAVITREAL INJECTION OF CONBERCEPT IN POLYPOIDAL CHOROIDAL VASCULOPATHY: Subgroup Analysis of the Aurora Study." 01/01/2008 - "The aim of the study was to assess the short-term efficacy of intravitreal injections of bevacizumab for polypoidal choroidal vasculopathy (PCV). " 01/01/2022 - "This study aimed to identify the changes in vessel density (VD) of the choriocapillaris (CC) and in subfoveal choroidal thickness (SFCT) and to evaluate their correlation with functional response after 3 monthly intravitreal injections of ranibizumab (loading phase [LP]) in patients affected by polypoidal choroidal vasculopathy (PCV). "
4.	Lasers (Laser) 12/01/2021 - "Thermal Laser Monotherapy for Extrafoveal Polypoidal Choroidal Vasculopathy." 06/01/2019 - "To investigate the different imaging characteristics between unilateral and bilateral polypoidal choroidal vasculopathy (PCV) cases, based on confocal scanning laser ophthalmoscope assessment. " 01/01/2013 - "To evaluate the validity of the novel and noninvasive retro-mode imaging modality of confocal scanning laser ophthalmoscopy (cSLO) for detecting the morphological features of polypoidal choroidal vasculopathy (PCV). " 01/01/2013 - "The noninvasive retro-mode imaging modality of confocal scanning laser ophthalmoscopy in polypoidal choroidal vasculopathy: a preliminary application." 10/01/2012 - "[Indentation of retinal pigment epithelium in polypoidal choroidal vasculopathy detected by retro-mode (scanning laser ophthalmoscopy)]."
5.	Injections 08/01/2016 - "The authors prospectively studied all the treatment-naive patients with polypoidal choroidal vasculopathy who were scheduled to undergo IVA using every 2-month injections or PRN after induction treatment between March 2013 and October 2013. " 11/01/2020 - "The polypoidal choroidal vasculopathy/aneurysmal Type 1 eyes with a diffuse pattern of pachyvessels required fewer injections during 12-month follow-up and showed a longer injection-free period after rescue photodynamic therapy." 10/01/2021 - "The present study aimed to quantify various factors of vessel morphology, including vessel diameter, length, and complexity (fractal dimension and lacunarity) of both choroidal neovascularization (CNV) and en face Haller vessels using optical coherence tomography angiography (OCTA) and en face structural optical coherence tomography in typical neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) and to identify factors associated with visual acuity (VA) loss and number of injections within a year after the day of OCTA. " 01/01/2017 - "Efficacy of intravitreal aflibercept injections for Japanese patients with polypoidal choroidal vasculopathy." 09/01/2023 - "The purpose of this study was to describe a case of polypoidal choroidal vasculopathy, showing a newly developed focal choroidal excavation during a 4-year follow-up period with multiple intravitreal antivascular endothelial growth factor injections. "