Abstract | SIGNIFICANCE: In patients initially diagnosed as having unilateral polypoidal choroidal vasculopathy, the visual prognosis of the better-seeing eye is highly favorable. If patients are overly pessimistic regarding their vision in the future, physicians can encourage patients by informing them of the small possibility for visual deterioration in the better-seeing eye. PURPOSE: The purpose of this study was to investigate the long-term changes in the visual acuity of the better-seeing eyes in patients with unilateral polypoidal choroidal vasculopathy. METHODS: This retrospective, single-institution study was performed with 221 patients who were diagnosed as having unilateral polypoidal choroidal vasculopathy and who were treated with intravitreal anti- vascular endothelial growth factor. Only patients with an initially uninvolved eye best-corrected visual acuity (BCVA) of 20/40 or better and who were followed up for at least 24 months were included. The changes in the BCVAs of the initially involved and uninvolved eyes as well as the better-seeing eyes were measured. For patients with three or more lines of uninvolved eye visual deterioration, the cause for the visual deterioration was identified. RESULTS: Patients were followed up for a mean of 43.1 ± 11.8 months after diagnosis. During the follow-up period, three or more lines of deterioration in the BCVA were noted in 61 initially involved eyes (27.6%) and 11 uninvolved eyes (4.9%). The reasons for uninvolved eye visual deterioration were neovascularization (n = 8), retinal vein occlusion (n = 2), and posterior capsule opacification (n = 1). At diagnosis, the BCVA of the better-seeing eye was 0.05 ± 0.08 (Snellen equivalents, 20/22). During the follow-up period, three or more lines of deterioration in the BCVA for the better-seeing eye were noted in eight patients (3.6%). CONCLUSIONS: Visual acuity of the better-seeing eye over time remained stable in most patients who were initially diagnosed as having unilateral polypoidal choroidal vasculopathy. As a result, the visual prognosis of the better-seeing eye is highly favorable in this condition.
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Authors | Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee |
Journal | Optometry and vision science : official publication of the American Academy of Optometry
(Optom Vis Sci)
Vol. 96
Issue 9
Pg. 686-694
(09 2019)
ISSN: 1538-9235 [Electronic] United States |
PMID | 31479024
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Recombinant Fusion Proteins
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- aflibercept
- Receptors, Vascular Endothelial Growth Factor
- Ranibizumab
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Topics |
- Aged
- Angiogenesis Inhibitors
(therapeutic use)
- Choroid
(blood supply)
- Choroidal Neovascularization
(diagnosis, drug therapy, physiopathology)
- Female
- Fluorescein Angiography
- Follow-Up Studies
- Humans
- Intravitreal Injections
- Male
- Middle Aged
- Polyps
(diagnosis, drug therapy, physiopathology)
- Prognosis
- Ranibizumab
(therapeutic use)
- Receptors, Vascular Endothelial Growth Factor
(therapeutic use)
- Recombinant Fusion Proteins
(therapeutic use)
- Retrospective Studies
- Treatment Outcome
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors)
- Visual Acuity
(physiology)
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