Tympanosclerosis

04/01/2017 - "CAPE has anti-inflammatory and antioxidant effects on the development of MS in myringotomized rats, so reduces the severity of tympanosclerosis."
09/01/2017 - "Melatonin increases total antioxidant status level and might have some effect on tympanosclerosis that develops after myringotomy."
10/01/2016 - "Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients."
09/01/2017 - "To demonstrate the possible preventative effects of melatonin and Vitamin C on tympanosclerosis in rats by using histopathology and determination of total antioxidant status total antioxidant status. "
01/01/2004 - "The study was performed to investigate the role of nitric oxide, free oxygen radicals, and antioxidants in development of tympanosclerosis in patients with chronic otitis media. "

02/01/2015 - "To demonstrate the inhibitory effects of clarithromycin on in vitro tympanosclerosis. "
02/01/2015 - "Does systemic clarithromycin therapy have an inhibitory effect on tympanosclerosis? "
02/01/2015 - "Acute otitis media and myringotomies induced tympanosclerosis, but clarithromycin reduced the severity of tympanosclerosis."

01/01/1999 - "An immunohistochemical study of inducible nitric oxide synthase in the rat middle ear, with reference to tympanosclerosis."
05/01/2001 - "Inducible nitric oxide synthase was seen more frequently in the patients with already established tympanosclerosis in a later phase of the disease."
05/01/2001 - "The biopsy specimens from patients with chronic otitis media and tympanosclerosis more often showed positive stainings for inducible nitric oxide synthase than the biopsy specimens from children with secretory otitis media. "
01/01/2014 - "Immunohistochemical investigation of inducible nitric oxide synthase, osteopontin, and calcium-sensing receptor in a myringosclerosis/tympanosclerosis model."
01/01/2014 - "To investigate roles of types of inflammation, inducible nitric oxide synthase (iNOS), osteopontin (OPN), and calcium sensing receptor (CaSR) in the tympanic membrane and middle ear in etiopathogenesis of myringosclerosis/tympanosclerosis (MT). "

09/01/2017 - "Recent studies have shown that free oxygen radicals are important in the formation of tympanosclerosis. "
01/01/2004 - "The study results suggest that nitric oxide, free oxygen radicals, and catalase may have a role in the development of tympanosclerosis in patients with chronic otitis media."
01/01/2004 - "The study was performed to investigate the role of nitric oxide, free oxygen radicals, and antioxidants in development of tympanosclerosis in patients with chronic otitis media. "

12/01/2008 - "Data from this study indicate that exogenous nitric oxide application did not change the occurence of tympanosclerosis in the rat model. "
12/01/2008 - "We aimed to elucidate the effects of exogenous nitric oxide application via myrigotomized rat tympanic membranes on tympanosclerosis. "
12/01/2008 - "Does exogenous nitric oxide influence tympanosclerosis? "
01/01/2004 - "The study results suggest that nitric oxide, free oxygen radicals, and catalase may have a role in the development of tympanosclerosis in patients with chronic otitis media."
01/01/2004 - "The study was performed to investigate the role of nitric oxide, free oxygen radicals, and antioxidants in development of tympanosclerosis in patients with chronic otitis media. "

01/01/2004 - "The study results suggest that nitric oxide, free oxygen radicals, and catalase may have a role in the development of tympanosclerosis in patients with chronic otitis media."
10/01/2016 - "This study investigated genetic polymorphisms affecting the inducible nitric oxide synthase, superoxide dismutase and catalase enzymes in chronic otitis media patients with and without tympanosclerosis, and the role of genetic susceptibility in the disease aetiology. "

03/01/2001 - "Since osteopontin (OPN) has been shown to participate in the pathological calcification, we here investigated whether OPN is involved in the process of calcification in tympanosclerosis. "
03/01/2001 - "Expression of osteopontin by exudate macrophages in inflammatory tissues of the middle ear: a possible association with development of tympanosclerosis."
09/01/2017 - "The aim of our study was to examine the expression level of genes encoding collagen type I, II, III and IV (COL1A1, COL2A1, COL3A1, COL4A1) and osteopontin (SPP1) in the tympanic membrane of patients with tympanosclerosis. "
09/01/2017 - "Gene expression profile of collagen types, osteopontin in the tympanic membrane of patients with tympanosclerosis."
09/01/2017 - "We observed that in the tympanic membrane of patients with tympanosclerosis, the expression of type I collagen is decreased, while the expression of type II and IV collagen and osteopontin is increased. "

07/01/2020 - "The aim of this study was to investigate Mesna's effects in easy dissection in type 4 tympanosclerosis cases and in the prevention of formation of new sclerotic plaques. "
07/01/2020 - "All patients were administered a 100% concentration of Mesna in the middle ear during tympanosclerosis surgery. "
07/01/2020 - "Use of Mesna in the treatment of ossicular chain fixation related to tympanosclerosis; prospective, clinical study."
06/01/2018 - "Mesna would be more effective by being used in higher concentrations in audiological surgeries, that its duration of operation world reduce and could being used in different indications including tympanosclerosis."
06/01/2018 - "The use of Mesna as a chemical dissector in higher concentrations may reduce the length of time of operation by providing more effective dissection as well as being used in otologic pathologies such as tympanosclerosis. "

10/01/2017 - "This study aimed to investigate the expression of DKK1 protein in an experimental model of tympanosclerosis and its possible role in the pathogenesis of this disorder. "
10/01/2017 - "Possible role of Dickkopf-1 protein in the pathogenesis of tympanosclerosis in a rat model."
09/01/2017 - "In the future, a treatment aiming to modulate these gene expressions and/or regulation of the degradation of their protein products could be used as a new medical approach for patients with tympanosclerosis."
10/01/2017 - "DKK1 protein is involved in the pathogenesis of tympanosclerosis by regulating the Wnt/β-catenin signalling pathway."
09/01/2017 - "The strong correlations between the expression of type I, II, IV collagen and osteopontin and the clinical stage of tympanosclerosis indicate the involvement of these proteins in excessive fibrosis and pathological remodeling of the tympanic membrane. "

10/01/2016 - "Genetic polymorphisms affecting antioxidant enzymes are present in tympanosclerosis patients."
01/01/2004 - "Comparison of free radicals and antioxidant enzymes in chronic otitis media with and without tympanosclerosis."
10/01/2016 - "This study investigated genetic polymorphisms affecting the inducible nitric oxide synthase, superoxide dismutase and catalase enzymes in chronic otitis media patients with and without tympanosclerosis, and the role of genetic susceptibility in the disease aetiology. "

03/01/2015 - "Efficacy of pre-operative computed tomography evaluation of the tympanic cavity for hearing improvement after stapes surgery for tympanosclerosis with stapes fixation."
05/01/2008 - "The aim of the present study was to evaluate the results of using stapedectomy to treat tympanosclerosis fixation of the footplate. "
03/01/2005 - "To study the long-term effect of stapes surgery on tympanosclerosis and its influence factors. "
01/01/2020 - "To review a single surgeon experience with revision pediatric stapes surgery for congenital stapes fixation (CSF) and tympanosclerosis (TS). "
04/01/2016 - "Nonotosclerotic stapes fixation has been proposed as the diagnosis in 30 to 40% of patients undergoing stapedectomy (after excluding rare congenital, systemic, and syndromic causes of stapes fixation and tympanosclerosis). "

06/01/2021 - "The study included 940 ears that underwent tympanoplasties due to CSOM, where 238 out of 940 (25.3%) of ears showed tympanosclerosis during tympanoplasty, intraoperatively, tympanosclerosis was localized to the eardrum in 174 of the 238 involved ears (73.1%), A 64 out of 238 (26.9%) of the ears with tympanosclerosis showed ossicular fixation, divided as 45 ears with Incudo-malleal fixation, 14 ears with stapes fixation, and 5 ears with triple ossicular fixation. "
02/01/2022 - "A retrospective cohort study, using medical records of 28 cases that underwent endoscopic transcanal tympanoplasty surgery due to tympanosclerosis from January 2016 to January 2020. "
10/01/2020 - "Pre-and post-operative（6 months as the final result） pure tone air-bone gap were compared between different types of tympanosclerosis to evaluate the short-term effect, the difference of hearing improvement between different type of tympanoplasties was also compared. "
10/01/2020 - "[Short-term effect of endoscopic one-stage tympanoplasty on tympanosclerosis]."
07/01/2020 - "Conclusion:For patients with stapes fixation due to tympanosclerosis, one-stage tympanoplasty can improve hearing threshold though ossicular chain reconstruction and stapes release. "

05/01/1988 - "Grommet insertion did not result in better long-term hearing in this study but was strongly associated with tympanosclerosis. "
03/10/2015 - "These include the risks of anaesthesia, the general risks of any surgery and the specific risks of otorrhoea and tympanosclerosis associated with the insertion of a tympanostomy tube. "
01/01/2001 - "Sex distribution in children with tympanosclerosis after insertion of a tympanostomy tube."
10/01/1995 - "We propose that the mass of a grommet appears to play less of a role than has previously been suggested in the pathogenesis of tympanosclerosis following grommet insertion and that duration of intubation may be the most significant factor."
06/01/1990 - "The aetiology of tympanosclerosis following grommet insertion remains controversial. "

08/01/2023 - "A novel technique in treatment of advanced tympanosclerosis: results of malleus replacement and loop prostheses combination; pure endoscopic transcanal approach."
01/01/2008 - "Comparative evaluation of the hearing results of total/partial stapedectomy technique and the prosthesis used within a 10-year follow-up period after stapedectomy in cases with dense tympanosclerosis and completely fixed stapes. "
01/01/2008 - "Analysis of long-term hearing after tympanosclerosis with total/partial stapedectomy and prosthesis used."
05/01/2004 - "Second-stage surgery for stapedectomy and placement of a prosthesis-like piston or total ossicular replacement prosthesis should be considered to obtain better hearing results in tympanosclerosis."
01/01/2002 - "The best of hearing improvement after repairment operations of conductive system were obtained in cases of stapedectomy, exchange of prosthesis after stapedectomy, reconstruction of system by TORP prosthesis, however smaller improvement after operations of synechias of stapes prosthesis with surroundings and postoperation of tympanosclerosis."

09/01/2010 - "To evaluate the effect of ossicular reconstruction with partial ossicular replacement prosthesis (PORP) in patients with tympanosclerosis. "
04/01/2006 - "In ossicular attic fixation, ossicular reconstruction using PORP can yield better results than mobilization of the major ossicles in patients with tympanosclerosis."
04/01/2006 - "To evaluate the effect of ossicular reconstruction with partial ossicular replacement prosthesis (PORP) in patients with tympanosclerosis. "
04/01/2006 - "[Effects of ossicular reconstruction with partial ossicular replacement prosthesis in patients with tympanosclerosis]."
10/01/1978 - "The most successful reconstrucitve approaches included removal of tympanosclerosis from tympanic membrane or isolated plaque from ossicular chain, the use of the Partial Ossicular Replacement Prosthesis (PORP), and the Total Ossicular Replacement Prosthesis (TORP)."