Platypnea Orthodeoxia Syndrome

Orthostatic dyspnea and fall of oxygen blood saturation when standing up which regress by assuming lying position.

Also Known As:

Orthodeoxia Syndrome, Platypnea; Orthodeoxia Syndromes, Platypnea; Orthodeoxias; POS Platypnea-Orthodeoxia Syndromes; Platypnea Orthodeoxia Syndromes; Platypnea-Orthodeoxia Syndrome, POS; Platypnea-Orthodeoxia Syndromes; Syndrome, POS Platypnea-Orthodeoxia; Syndrome, Platypnea Orthodeoxia; Syndrome, Platypnea-Orthodeoxia; Orthodeoxia; POS Platypnea Orthodeoxia Syndrome; POS Platypnea-Orthodeoxia Syndrome; Platypnea-Orthodeoxia Syndrome

Networked: 97 relevant articles (13 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Dyspnea (Shortness of Breath)
2.	Rare Diseases (Rare Disease)
3.	Hypoxia (Hypoxemia)
4.	Lung Diseases (Lung Disease)
5.	Infections

Experts

1.	Iliadis, Kosmas: 2 articles (01/2022 - 11/2019)
2.	Akagi, Teiji: 2 articles (04/2018 - 07/2014)
3.	Ito, Hiroshi: 2 articles (04/2018 - 07/2014)
4.	Nakagawa, Koji: 2 articles (04/2018 - 07/2014)
5.	Takaya, Yoichi: 2 articles (04/2018 - 07/2014)
6.	Meier, B: 2 articles (10/2007 - 12/2001)
7.	Boulia, Stavroula: 1 article (01/2022)
8.	Krassas, Athanassios: 1 article (01/2022)
9.	Tzifa, Aikaterini: 1 article (01/2022)
10.	Dickson, Christopher: 1 article (10/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Platypnea Orthodeoxia Syndrome:

1.	Oxygen (Dioxygen)IBA 06/02/2021 - "Platypnoea-orthodeoxia syndrome (POS) is a rare condition characterised by the association of dyspnoea and arterial oxygen desaturation induced by standing and relieved by recumbency. " 05/01/2002 - "Platypnoea-orthodeoxia (P.O.) syndrome is the association of dyspnoea and arterial oxygen desaturation aggravated in the erect position and relieved in the supine position. " 09/15/1999 - "Arterial pO2 was 33 mm Hg under 41 O2/min nasal oxygen supplement and improved to 74 mm Hg under 81 O2/min. Arterial pO2 deteriorated in upright position (orthodeoxia). " 10/31/2023 - "Platypnoea-orthodeoxia syndrome is characterised by dyspnoea and oxygen desaturation in the upright position usually caused by an extracardiac shunt and less often due to dynamic factors that accentuate an intracardiac right-to-left shunt. " 03/01/2023 - "Platypnoea-orthodeoxia syndrome affects nocturnal oxygen desaturation: A case report."
2.	Polymyxin B (Aerosporin)FDA LinkGeneric 09/01/2014 - "The patient was treated successfully with early administration of immunosuppressive therapies and polymyxin B-immobilized fiber column-direct hemoperfusion, and her platypnea-orthodeoxia improved with resolution of the underlying parenchymal lung disease. "
3.	Phospholipids (Phosphatides)FDA LinkGeneric 12/03/2023 - "CASE REPORT We report a case of a 63-year-old man, known to have systemic lupus erythematosus (SLE) and positive anti-phospholipid antibodies but with no prior thrombotic events, admitted with symptoms of SARS-COV2 infection, and developed symptoms of Platypnea-Orthodeoxia Syndrome during his hospitalization, further evaluation by a transthoracic echocardiography revealed he had PFO with a right-to-left shunt which was treated successfully with percutaneous device closure. "
4.	AntibodiesIBA 12/03/2023 - "CASE REPORT We report a case of a 63-year-old man, known to have systemic lupus erythematosus (SLE) and positive anti-phospholipid antibodies but with no prior thrombotic events, admitted with symptoms of SARS-COV2 infection, and developed symptoms of Platypnea-Orthodeoxia Syndrome during his hospitalization, further evaluation by a transthoracic echocardiography revealed he had PFO with a right-to-left shunt which was treated successfully with percutaneous device closure. "
5.	Amiodarone (Amiodarona)FDA LinkGeneric 03/01/1994 - "Orthodeoxia in amiodarone-induced acute reversible pulmonary damage." 05/01/1999 - "Acute alveolar hemorrhage and orthodeoxia induced by intravenous amiodarone."
6.	Transfer Factor (Factor, Transfer)IBA 11/01/1992 - "Although these four criteria appear straightforward, there may be other features that are not always present--namely: 1. low transfer factor (diffusing capacity); 2. shortness of breath, with or without platypnoea and orthodeoxia; 3. increased cardiac output and reduced pulmonary vascular pressures; 4. small (or no) increase in pulmonary vascular resistance when the patient is breathing low oxygen mixtures. "
7.	SteroidsIBA 02/01/2011 - "We describe an unusual case of orthodeoxia platypnea syndrome exacerbated by right ventricular inflow obstruction due to iatrogenic steroid-induced adipose deposition in cardiac tissues. " 02/01/2011 - "This case is unique because long-term steroid use resulted in reverse Lutembacher physiology and clinical orthodeoxia platypnea syndrome by inducing lipomatous hypertrophy of the interatrial septum and compression of the right atrium." 02/01/2011 - "Orthodeoxia platypnea syndrome in a patient with lipomatous hypertrophy of the interatrial septum due to long-term steroid use."
8.	Propranolol (Inderal)FDA LinkGeneric 01/01/1994 - "Orthodeoxia and platypnea in liver cirrhosis: effects of propranolol."
9.	Propafenone (Rythmol)FDA LinkGeneric 12/01/2003 - "Transient platypnea-orthodeoxia-like syndrome induced by propafenone overdose in a young woman with Ebstein's anomaly."
10.	Organophosphorus CompoundsIBA 07/01/2022 - "We report a case series of three cases that were reported after ingestion of organophosphorus compounds and developed breathlessness later in the course of the hospital stay, which was diagnosed as Platypnea orthodeoxia syndrome resulting from organophosphorus poisoning. "

Therapies and Procedures

1.	Pneumonectomy (Lung Volume Reduction) 04/01/2007 - "Platypnea-orthodeoxia syndrome after pneumonectomy relieved by mediastinal repositioning." 01/01/2022 - "Some patients present with Platypnoea-Orthodeoxia Syndrome in the early-or-late post-operative period after major lung resection (lobectomy/pneumonectomy). " 10/01/2021 - "Platypnoea-orthodeoxia syndrome due to a right-to-left interatrial shunt following pneumonectomy." 12/01/2009 - "Platypnea-orthodeoxia syndrome: a rare complication after right pneumonectomy." 01/01/2020 - "We describe a case of platypnea-orthodeoxia syndrome (POS) due to atrial septal defect (ASD) occurring in the early postoperative course of a right pneumonectomy. "
2.	Stents 10/31/2023 - "Once the patency of the left main bronchus was restored by deploying a stent, the left lower lobe expanded, the mediastinum returned to its normal position and there was resultant resolution of the platypnoea-orthodeoxia. " 07/01/1999 - "The post-radiation course was complicated by a severe radiation bronchitis; the onset of platypnea-orthodeoxia signalled the development of severe bronchial stenosis that was transiently relieved, initially by dilatation, and later by stent placement, though the patient ultimately died of a pulmonary hemorrhage. "
3.	Hemoperfusion 09/01/2014 - "The patient was treated successfully with early administration of immunosuppressive therapies and polymyxin B-immobilized fiber column-direct hemoperfusion, and her platypnea-orthodeoxia improved with resolution of the underlying parenchymal lung disease. "
4.	Decompression 01/01/2021 - "PFO closure for other indications such as platypnoea-orthodeoxia syndrome, decompression illness and paradoxical embolism are based largely on case series with good clinical outcomes. " 09/01/2008 - "PFO has also been associated with decompression illness in divers and to minor diseases such as platypnea-orthodeoxia syndrome and high-altitude pulmonary edema. " 01/01/2021 - "While most people do not have secondary manifestations of a PFO, some reported sequelae include ischaemic stroke, migraine, platypnoea-orthodeoxia syndrome and decompression illness. " 04/01/2006 - "Pulmonary hypertension and entities like decompression illness, migraine with aura or plathypnea-orthodeoxia have been found to have a higher prevalence of PFO with RLSh. " 04/01/2014 - "In 2014, percutaneous patent foramen ovale (PFO) closure is a frequently performed procedure; the bulk of these procedures being carried out for secondary prevention of cryptogenic stroke, along with other indications, such as prevention of decompression illness, platypnoea-orthodeoxia syndrome and migraine. "
5.	Therapeutics 01/01/2019 - "To follow is a case of iatrogenic platypnea-orthodeoxia syndrome secondary to heart failure guideline directed medical therapy in a 79 year-old woman." 06/01/2021 - "All the patients presenting with platypnoea-orthodeoxia required oxygen therapy during the course of treatment. " 11/01/2010 - "Correct evaluation of RF (by investigating orthodeoxia and response to oxygen therapy) enables the suspicion of a shunt, which can be confirmed through simple, safe and cost-effective exams. " 11/01/2000 - "Patients with HPS have orthodeoxia and poor responsiveness to oxygen therapy, and correction of hypoxemia after LT may be delayed. " 06/01/2021 - "Platypnoea-orthodeoxia syndrome is common in patients with stage 2 COVID 19 infection who require oxygen therapy. "