Organizing Pneumonia

Any obstructive lung disease characterized by consolidated formation of GRANULATION TISSUE polyps within ALVEOLAR DUCTS AND ALVEOLI. It is classified as either primary (cryptogenic organizing pneumonia) or secondary organizing pneumonia. Secondary organizing pneumonia after transplantation is called bronchiolitis obliterans syndrome.

Also Known As:

Networked: 460 relevant articles (20 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pneumonia (Pneumonitis)
2.	COVID-19
3.	Lung Diseases (Lung Disease)
4.	Infections
5.	Organizing Pneumonia

Experts

1.	Kawabata, Yoshinori: 5 articles (01/2015 - 01/2011)
2.	Suda, Takafumi: 4 articles (11/2020 - 01/2007)
3.	Gemma, Akihiko: 3 articles (01/2022 - 01/2019)
4.	Kubota, Kaoru: 3 articles (01/2022 - 01/2019)
5.	Saito, Yoshinobu: 3 articles (01/2022 - 01/2019)
6.	Seike, Masahiro: 3 articles (01/2022 - 01/2019)
7.	Terasaki, Yasuhiro: 3 articles (02/2021 - 08/2015)
8.	Kawamura, Tetsuji: 3 articles (01/2021 - 12/2006)
9.	Hattori, Noboru: 3 articles (11/2020 - 01/2009)
10.	Wang, Guochun: 3 articles (10/2020 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Organizing Pneumonia:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 08/01/2023 - "This report illustrates a case of acute fibrinous organizing pneumonia wherein the patient responded well to corticosteroids." 01/01/2006 - "Transbronchial lung biopsies revealed organizing pneumonia (OP) that was rapidly improved with corticosteroid. " 12/01/2023 - "This resulted in the development of drug-induced organizing pneumonia, which was alleviated by discontinuing drug administration and giving corticosteroids. " 11/02/2022 - "There are no firm guidelines for the treatment of acute fibrinous and organizing pneumonia, but some patients may positively respond to corticosteroids." 11/01/2022 - "Organizing pneumonia (OP) promptly responds to corticosteroids. "
2.	SteroidsIBA 09/01/2023 - "At the time of presentation, she was on long-term steroids for post-coronavirus disease (COVID) organizing pneumonia diagnosed three months back. " 01/01/2023 - "A transbronchial lung biopsy revealed organizing pneumonia and lymphocytic infiltration, and steroids were administered. " 12/01/2022 - "The goal of this scoping review is to conduct a systematic search of the literature to determine what regimens have been utilized to treat steroid refractory organizing pneumonia and to characterize the evidence supporting their use." 01/01/2019 - "Steroid treatment is often provided for patients with organizing pneumonia; however, the effect of steroid administration on recurrence rate needs to be examined. " 12/06/2018 - "Successful steroid treatment for acute fibrinous and organizing pneumonia: A case report."
3.	Prednisolone (Predate)FDA LinkGeneric 05/01/2021 - "Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function. " 01/01/2012 - "Because organizing pneumonia was suspected, prednisolone was begun and improvement was seen. " 11/13/2023 - "Treatment with prednisolone improved the course of cold agglutinin disease and organizing pneumonia in a similar manner. " 10/01/2019 - "Focal organizing pneumonia simulating lung malignancy: treated with prednisolone." 09/01/2011 - "He had been administered 30 mg of prednisolone per day for organizing pneumonia, probably due to the RA, for about 3 months before admission for a lumbar compression fracture. "
4.	FibrinIBA 04/01/2015 - "This study examined the clinical significance of intra-alveolar fibrin deposition (IAFD) in transbronchial lung biopsy specimens obtained from patients with organizing pneumonia. " 11/24/2023 - "Acute fibrinous and organizing pneumonia (AFOP) is a rare acute or subacute interstitial lung disorder characterized by the deposition of fibrin within the alveoli and organizing pneumonia with a patchy distribution. " 01/01/2022 - "In those patients with acute or exudative pattern, two lesions were distinguished: classic hyaline membrane; fibrin "plug" in alveolar space (acute fibrinous organizing pneumonia, AFOP). " 12/04/2021 - "Histopathology of the lung tissue showed a dominant of intra-alveolar fibrin and organizing pneumonia. " 07/01/2021 - "Acute fibrinous and organizing pneumonia (AFOP) is an unusual pathological pattern which is characterized by intra-alveolar deposition of fibrin (fibrin ball) and organizing pneumonia in a scattered distribution, and the pathological diagnosis plays an irreplaceable role in the diagnosis. "
5.	Immune Checkpoint InhibitorsIBA 04/01/2023 - "Immune checkpoint inhibitors are often associated with organizing pneumonia. " 01/01/2020 - "Immune checkpoint inhibitors (ICIs) have been shown to improve overall and progression-free survival in various cancers but have been associated with various immune-related adverse events (IRAEs), including interstitial lung disease, especially organizing pneumonia. " 11/15/2020 - "Micronodular Pattern of Organizing Pneumonia or Hypersensitivity Pneumonia Induced by an Immune Checkpoint Inhibitor?" 11/15/2020 - "Reply to Takimoto: Micronodular Pattern of Organizing Pneumonia or Hypersensitivity Pneumonia Induced by an Immune Checkpoint Inhibitor?" 01/01/2018 - "Here, we report a fatal case of immune checkpoint inhibitor-associated pneumonitis initially presenting with an organizing pneumonia, but who rapidly developed acute respiratory distress syndrome (confirmed histologically at the time of autopsy). "
6.	GlucocorticoidsIBA 06/16/2023 - "Glucocorticoid pulse therapy in an elderly patient with post-COVID-19 organizing pneumonia: A case report." 01/01/2023 - "Glucocorticoid Therapy in COVID-19-Induced Organizing Pneumonia: A Rare Occurrence." 08/01/2019 - "Some case reports suggested that secondary organizing pneumonia (SOP) could occur at the recovery stage of the influenza virus infection, and the treatment with glucocorticoid was effective. " 08/01/2019 - "Glucocorticoid treatment of suspected organizing pneumonia after H7N9 infection: A case report." 03/18/2021 - "In this article, we talk about a subgroup of patients with organizing pneumonia following COVID-19 pneumonia that could be effectively treated with systemic glucocorticoids. "
7.	Mycophenolic Acid (Cellcept)FDA LinkGeneric 11/01/2022 - "Post COVID-19 organizing pneumonia treated with mycophenolate mofetil." 11/01/2009 - "Severe acute fibrinous and organizing pneumonia (AFOP) causing ventilatory failure: successful treatment with mycophenolate mofetil and corticosteroids." 12/01/2010 - "The authors report the association of organizing pneumonia (OP) and a Pneumocystis jiroveci infection in a woman who benefited from a kidney transplant 13 years before and was under corticoids, cyclosporine and mycophenolate mofetil. "
8.	CytokinesIBA 06/15/2006 - "However, TLR2(-/-) mice produced proinflammatory cytokines, recruited neutrophils to the lung alveoli, and cleared the infection without progression to organizing pneumonia and disseminated disease. " 04/01/2016 - "Clinical Characteristics and Cytokine Profiles of Organizing Pneumonia in Patients with Rheumatoid Arthritis Treated with or without Biologics."
9.	Azathioprine (Imuran)FDA LinkGeneric 01/01/2014 - "IgG4-related lung disease with organizing pneumonia effectively treated with azathioprine." 04/01/2019 - "This report presents the case of a 56-year-old woman with systemic lupus erythematosus who was diagnosed with an organizing pneumonia and showed a poor response to steroid and azathioprine treatment. "
10.	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/01/2010 - "The authors report the association of organizing pneumonia (OP) and a Pneumocystis jiroveci infection in a woman who benefited from a kidney transplant 13 years before and was under corticoids, cyclosporine and mycophenolate mofetil. "

Therapies and Procedures

1.	Therapeutics 01/01/2023 - "In the later stage, organizing pneumonia or diffuse alveolar damage pattern are predominant CT findings and anti-inflammatory therapies are more beneficial. " 12/06/2018 - "Since the acute fibrinous and organizing pneumonia (AFOP) was first described by Beasley in 2002, some case reports of patients aged from 38 d to 80 years have been published worldwide, but there is still no standard therapy for this disease and the treatment methods remain controversial. " 10/01/2018 - "Our aim was to examine the clinical and radiological features, laboratory findings, diagnostic approach, and response to therapy in subjects with cryptogenic (COP) and secondary organizing pneumonia (SOP). " 02/01/2012 - "Radiographic and CT features of radiation-induced organizing pneumonia syndrome after breast-conserving therapy." 04/01/2018 - "Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: A case report."
2.	Radiotherapy 01/01/2019 - "Spontaneous resolution of thoracic radiation therapy-induced organizing pneumonia: A case series." 01/01/2019 - "We retrospectively analyzed the data of 9 patients with organizing pneumonia induced by radiation therapy. " 05/01/2018 - "Radiation-induced organizing pneumonia (OP) reportedly occurs in ~2% of patients who receive whole-breast radiotherapy (WBRT). " 05/01/2013 - "The patient under went a trans bronchial biopsy and the pathological diagnosis was compatible with an organizing pneumonia presumably associated with radiotherapy. " 08/01/2012 - "Organizing pneumonia after stereotactic ablative radiotherapy of the lung."
3.	Aftercare (After-Treatment) 09/01/2022 - "Her clinical status improved significantly the day after treatment initiation, making organizing pneumonia as the likely culprit for her initial decompensation. " 05/01/2021 - "A Duck after Treatment for Extensive Organizing Pneumonia." 08/01/2011 - "The CT pattern of organizing pneumonia, a subpleural pattern, was frequently observed after treatment of L. " 04/01/2015 - "After treatment of the pneumonitis, a lung biopsy was performed owing to persistent chest symptoms, which revealed bronchiolitis obliterans with organizing pneumonia. " 10/06/2020 - "After a thorough checkup, bilateral consolidation and infiltration of the lungs were documented and a percutaneous lung biopsy confirmed organizing pneumonia after treatment with broad-spectrum empirical antibiotics failed. "
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 07/01/2011 - "A 9-year-old and a 17-year-old male patients affected by metastatic Ewing sarcoma developed an organizing pneumonia after high-dose chemotherapy with autologous peripheral blood stem cell transplantation followed by total-lung irradiation. " 11/01/2002 - "Filgrastim treatment of acute myelogenous leukemia (M7) relapse after allogeneic peripheral stem cell transplantation resulting in both graft-versus-leukemia effect with cytogenetic remission and chronic graft-versus-host disease manifesting as polyserositis and subsequent bronchiolitis obliterans with organizing pneumonia."
5.	Intensity-Modulated Radiotherapy (Radiotherapy, Intensity Modulated) 05/01/2015 - "This study investigated the effectiveness of stereotactic body radiotherapy with helical TomoTherapy (T-SBRT) for treating medically inoperable primary and second-primary early stage non-small-cell lung neoplasm (SPLN) and evaluated whether the movement of organizing pneumonia (OP) within the irradiation field (IF) can be detected via analysis of radiological changes. "