mu-Crystallins
A subclass of crystallins expressed highly in lens of diurnal Australian MARSUPIALS and in neural tissue, muscle, and kidney in humans. It is not a structural protein accounting for the transparency of the human lens unlike other crystallins but instead plays a role in thyroid hormone bioavailability. It is also a cerebral ketimine reductase which reduces cyclic imines (e.g., DELTA(1)-PIPERIDINE-2-CARBOXYLIC ACID; CYSTATHIONINE KETIMINE and LANTHIONINE KETIMINE) in mammalian brain. Mutations in mu-crystallins are associated with an autosomal dominant NONSYNDROMIC DEAFNESS.
Also Known As:
Ketimine Reductase mu Crystallin; NADP Regulated Thyroid Hormone Binding Protein; Protein, CRYM; Protein, THBP; Reductase mu-Crystallin, Ketimine; mu Crystallins; mu, Crystallin; mu-Crystallin, Ketimine Reductase; CRYM Protein; Crystallin mu; Ketimine Reductase mu-Crystallin; NADP-Regulated Thyroid Hormone Binding Protein; THBP Protein
Networked: 11
relevant articles (0 outcomes,
0 trials/studies)
Bio-Agent Context: Research Results
Experts
1. | Hashizume, Kiyoshi:
2 articles
(07/2010 - 09/2007)
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2. | Suzuki, Satoru:
2 articles
(07/2010 - 09/2007)
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3. | Hashizume, K:
2 articles
(07/2009 - 06/2006)
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4. | Suzuki, S:
2 articles
(07/2009 - 06/2006)
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5. | Jeon, Mi Yang:
1 article
(05/2019)
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6. | Jeon, Songhee:
1 article
(05/2019)
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7. | Jeong, Ha Jin:
1 article
(05/2019)
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8. | Kim, Ji Hyun:
1 article
(05/2019)
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9. | Liu, Quan Feng:
1 article
(05/2019)
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10. | Urnuhsaikhan, Enerelt:
1 article
(05/2019)
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Related Diseases
1. | Neoplasms (Cancer)
07/01/2009
- " CRYM protein was increased in cancer tissue and decreased in samples from patients after hormonal therapy. " 03/01/2002
- " Conversely, two genes that were down-regulated during tumor progression in the CWR22 model system were validated in vivo: crystallin mu (CRYM) and a LIM-domain protein LMO4 both showed significantly lower mRNA levels in hormone-refractory tumors as compared with primary tumors (P < 0.001). " 05/01/2019
- " Hippocalcin, α-spectrin, ovarian tumor domain-containing ubiquitin aldehyde-binding protein 1 (otub1), mu-crystallin, serine racemase, and rho GDP dissociation inhibitor 1, which are related to neurogenesis, neuroprotection, and synaptic strength, were upregulated in the hippocampus by moderate exercise. " 02/01/2007
- " However, aldolase C fructose-biphosphate, creatine kinase, B chain dihydrolipoyl dehydrogenase, enolase 2, fumarate hydratase, HSP60, lactoylglutathione lyase, lucine aminopeptidase, Mu-crystallin homolog, NADH-UO 24, neurofilament triplet L protein, septin 2, stathmin and vacuolar ATP synthase subunit E were downregulated in glioblastoma multiform compared with non-tumor tissues. "
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2. | Deafness (Deaf Mutism)
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3. | Nonsyndromic Deafness
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4. | Hearing Loss (Hearing Impairment)
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5. | Facioscapulohumeral Muscular Dystrophy
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Related Drugs and Biologics
Related Therapies and Procedures