Translationally-Controlled 1 Tumor Protein

A highly expressed protein in tumor cells, encoded by Tpt1 gene. It's involved in various cellular activities including protein synthesis, calcium-binding, MICROTUBULE stabilization, growth, and cell survival. Also, Tpt1 identified as a direct target gene of P53 tumor suppression.

Also Known As:

Tumor Protein, Translationally-Controlled 1; Factor, Histamine Releasing; Histamine Releasing Factor, Lymphocyte Dependent; Protein, TPT1; Protein, Translationally-Controlled Tumor; Translationally Controlled Tumor Protein; Tumor Protein, Translationally Controlled 1; Tumor Protein, Translationally-Controlled; Histamine Releasing Factor; Histamine Releasing Factor, Lymphocyte-Dependent; Histamine-Releasing Factor (IgE-Dependent); Protein P23, Ehrlich Ascites Tumor; TPT1 Protein; Translationally-Controlled Tumor Protein

Networked: 196 relevant articles (4 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Translationally-Controlled 1 Tumor Protein: 196
  - Neoplasm Proteins: 2
    - Translationally-Controlled 1 Tumor Protein: 196
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Translationally-Controlled 1 Tumor Protein: 196

Experts

1.	Lee, Kyunglim: 20 articles (08/2022 - 01/2008)
2.	Kawakami, Toshiaki: 6 articles (01/2022 - 01/2012)
3.	Kawakami, Yuko: 5 articles (01/2022 - 01/2012)
4.	Amson, Robert: 5 articles (01/2021 - 11/2003)
5.	Telerman, Adam: 5 articles (01/2021 - 11/2003)
6.	Maeng, Jeehye: 5 articles (01/2017 - 12/2012)
7.	Cho, Hyunsoo: 4 articles (08/2022 - 01/2021)
8.	Efferth, Thomas: 4 articles (01/2021 - 02/2005)
9.	Demarta-Gatsi, Claudia: 4 articles (01/2019 - 04/2015)
10.	Mécheri, Salaheddine: 4 articles (01/2019 - 04/2015)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 01/26/2017 - "Dimerized Translationally Controlled Tumor Protein-Binding Peptide Ameliorates Atopic Dermatitis in NC/Nga Mice." 11/01/2012 - "Interestingly, sera from atopic dermatitis patients showed increased reactivity to ssDNA and β-galactosidase and increased levels of histamine-releasing factor. " 07/27/1989 - "Spontaneous release of histamine from basophils and histamine-releasing factor in patients with atopic dermatitis and food hypersensitivity." 07/27/1989 - "To determine whether patients with atopic dermatitis and food hypersensitivity had similar high rates of spontaneous histamine release in vitro, whether dietary elimination of relevant food antigens affected this release, and whether a cytokine, histamine-releasing factor, could account for it, we evaluated 63 patients with atopic dermatitis and food hypersensitivity (38 of whom had eliminated the offending foods from their diets), 20 patients with atopic dermatitis without food hypersensitivity, and 18 normal volunteers. "
2.	Neoplasms (Cancer) 10/26/2004 - "Because TCTP encodes for a histamine-releasing factor, we tested the hypothesis that inhibitors of the histaminic pathway could be effective against tumor cells. " 01/01/2023 - "Growing evidence indicates that the translationally controlled tumor protein (TCTP) may be a clinically relevant marker for identifying poorly differentiated aggressive BC tumors. " 01/01/2023 - "Translationally Controlled Tumor Protein (TCTP) serves as a pro-survival factor in tumor cells, inhibiting the mitochondrial apoptosis pathway by enhancing the function of anti-apoptotic Bcl-2 family members Mcl-1 and Bcl-xL. " 08/15/2022 - "Translationally controlled tumor protein: the mediator promoting cancer invasion and migration and its potential clinical prospects." 10/21/2021 - "Translationally controlled tumor protein (TCTP) is expressed in many tissues, particularly in human tumors. "
3.	Malaria 01/01/2016 - "Protection against malaria in mice is induced by blood stage-arresting histamine-releasing factor (HRF)-deficient parasites." 04/01/2015 - "Histamine-releasing factor produced by erythrocytic stages of the parasite is thought to play a role in the pathogenesis of severe malaria. " 04/01/2015 - "Plasmodium spp., which causes malaria, produces a histamine-releasing factor (HRF), an orthologue of mammalian HRF. " 01/01/2017 - "Immunological memory to blood-stage malaria infection is controlled by the histamine releasing factor (HRF) of the parasite." 01/01/2019 - "Histamine releasing factor and elongation factor 1 alpha secreted via malaria parasites extracellular vesicles promote immune evasion by inhibiting specific T cell responses."
4.	Food Hypersensitivity (Food Allergy) 01/01/2022 - "Novel inhibitors of histamine-releasing factor suppress food allergy in a murine model." 12/01/2017 - "Histamine-releasing factor enhances food allergy." 12/01/2017 - "Histamine-releasing factor: a promising therapeutic target for food allergy." 12/01/2017 - "In this issue of the JCI, Ando et al. provide a causal link between histamine-releasing factor (HRF) interactions with IgE and food allergy in a murine model. " 07/27/1989 - "Mononuclear cells from persons with food allergies spontaneously produced a histamine-releasing factor in vitro that provoked the release of histamine from the basophils of other food-sensitive persons, but not from those of normal controls. "
5.	Asthma (Bronchial Asthma) 01/01/1996 - "The aim of this study was to assess the effect of NS on the serum neutrophil (NCA) and eosinophil (ECA) chemotactic activity and mononuclear cells-derived histamine releasing factor (HRF) activity in 14 patients with seasonal allergic asthma. " 01/01/1987 - "In our previous studies we reported that lymphocytes from patients with asthma spontaneously produce histamine-releasing factor (HRF) in vitro. " 01/01/2023 - "Histamine-releasing factor in severe asthma and rhinovirus-associated asthma exacerbation." 09/01/1991 - "Respiratory viruses induce production of histamine-releasing factor by mononuclear leukocytes: a possible role in the mechanism of virus-induced asthma." 01/01/1990 - "Human Basophil Degranulation Test (HBDT) has been employed for the research of Histamine Releasing Factor (HRF) from macrophages in asthma. "

Related Drugs and Biologics

1.	Cytokines
2.	Peptides (Polypeptides)
3.	Antigens
4.	Proteins (Proteins, Gene)
5.	Immunoglobulin E (IgE)
6.	Biomarkers (Surrogate Marker)
7.	Chemokines
8.	artemisinin (artemisinine)
9.	Sertraline (Zoloft)
10.	Serotonin (5 Hydroxytryptamine)

Related Therapies and Procedures

1.	Immunotherapy
2.	Nephrectomy
3.	Therapeutics