UDP-Glucuronosyltransferase 1A9

A PPAR alpha and PPAR gamma target gene. The enzyme plays an important role in elimination and DETOXIFICATION of drugs, XENOBIOTICS, and metabolizing endogenous compounds, including CATECHOLESTROGENS and FIBRATES.

Also Known As:

1A9, UDP-Glucuronosyltransferase; 1A9, Uridine Diphosphate-Glucuronosyltransferase; Protein, UGT1A9; UDP Glucuronosyltransferase, UGT1A9; UGT1A9 UDP-Glucuronosyltransferase; UDP-Glucuronosyltransferase, UGT1A9; UGT1A9 Protein; Uridine Diphosphate-Glucuronosyltransferase 1A9

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Hexosyltransferases
        Glucuronosyltransferase: 625
        UDP-Glucuronosyltransferase 1A9: 5
        human UGT1A9 protein
        mouse Ugt1a9 protein

Experts

1.	Bautista, J: 1 article (11/2016)
2.	Calvo, N: 1 article (11/2016)
3.	López de la Manzanara, V: 1 article (11/2016)
4.	Moreno de la Higuera, M A: 1 article (11/2016)
5.	Pérez-Flores, I: 1 article (11/2016)
6.	Rodriguez Cubillo, B: 1 article (11/2016)
7.	Shabaka, A: 1 article (11/2016)
8.	Sánchez-Fructuoso, A I: 1 article (11/2016)
9.	Caron, Patrick: 1 article (04/2015)
10.	Fallon, John K: 1 article (04/2015)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2016 - "Presence of T-275A and C-2152T Polymorphisms of the Promoter Region of Uridine Diphosphate-Glucuronosyltransferase 1A9 Increases Mortality From Digestive Tumors: Results After 10 Years of Follow-up in a Renal Transplant Population." 08/01/2003 - "Functional characterization of human UDP-glucuronosyltransferase 1A9 variant, D256N, found in Japanese cancer patients." 04/01/2015 - "In normal kidney tissues, only UGT1A9 protein levels correlated with mRNA levels, whereas UGT1A6, UGT1A9, and UGT2B7 quantification correlated significantly with their mRNA levels in tumor kidneys. "
2.	Parkinson Disease (Parkinson's Disease) 11/01/2012 - "Association of UDP-glucuronosyltransferase 1A9 polymorphisms with adverse reactions to catechol-O-methyltransferase inhibitors in Parkinson's disease patients."
3.	Breast Neoplasms (Breast Cancer) 04/01/2014 - "Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9."

Related Drugs and Biologics

1.	Catechol O-Methyltransferase Inhibitors
2.	Luteolin
3.	Glucuronides
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)