CLC-2 Chloride Channels

One of the nine mammalian members of the CHLORIDE CHANNEL family involved in chloride ion transport.It has several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport.

Also Known As:

Networked: 34 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sepúlveda, Francisco V: 4 articles (01/2020 - 09/2004)
2.	Jentsch, Thomas J: 4 articles (01/2018 - 05/2004)
3.	Catalán, Marcelo A: 2 articles (01/2020 - 02/2012)
4.	Niemeyer, María Isabel: 2 articles (01/2020 - 09/2004)
5.	Orozco, Ian J: 2 articles (01/2018 - 03/2014)
6.	Blikslager, Anthony T: 2 articles (12/2015 - 08/2010)
7.	Auberson, Muriel: 2 articles (03/2014 - 06/2007)
8.	Flores, Carlos A: 2 articles (02/2012 - 09/2004)
9.	Melvin, James E: 2 articles (02/2012 - 09/2005)
10.	Cid, L Pablo: 2 articles (09/2005 - 09/2004)

Related Diseases

1.	Ischemia 08/01/2010 - "We have previously shown an important role of the chloride channel ClC-2 in orchestrating repair of tight junctions in ischemia-injured mucosa. " 05/07/2015 - "4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2."
2.	Seizures (Absence Seizure) 03/01/2016 - "Thus, the voltage-gated chloride channel Clc-2, which was functionally upregulated in CA1 pyramidal cells after seizures, may provide protection against TLE by its regulation of action potentials, Clc-2 currents and GABAARs in the CA1 region of the hippocampus. "
3.	Hypoxia (Hypoxemia) 05/07/2015 - "4,4'-Diisothiocyanostilbene-2,2'-disulfonic Acid (DIDS) Ameliorates Ischemia-Hypoxia-Induced White Matter Damage in Neonatal Rats through Inhibition of the Voltage-Gated Chloride Channel ClC-2."
4.	Lung Diseases (Lung Disease) 10/26/2004 - "The objectives of this study are to identify single nucleotide polymorphisms (SNPs) in the airway epithelial chloride channel, CLC-2, and correlate these polymorphisms with CF lung disease. "
5.	Glioma (Gliomas) 07/01/2006 - "The aim of the present study was to observe the effect of siRNA, which was designed to target volume-regulated chloride channel ClC-2 gene, on the proliferation of a human glioma cell line U-87. "

Related Drugs and Biologics

1.	4,4'- Diisothiocyanostilbene- 2,2'- Disulfonic Acid (DIDS)
2.	Small Interfering RNA (siRNA)
3.	Lubiprostone
4.	Chloride Channels (Chloride Channel)
5.	Proteins (Proteins, Gene)
6.	Fatty Acids (Saturated Fatty Acids)
7.	Catenins
8.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
9.	GTP-Binding Proteins (G-Protein)
10.	Retinaldehyde (Retinal)