Radiation Fibrosis Syndrome (Radiation Fibrosis)

Radiation-induced fibrosis due to increased production of FIBRIN. Its symptoms include CERVICAL DYSTONIA, difficulty with speech and swallowing, swelling in the radiation field and TRISMUS.

Also Known As:

Networked: 357 relevant articles (18 outcomes, 37 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Fibrosis (Cirrhosis)
2.	Residual Neoplasm
3.	Squamous Cell Carcinoma of Head and Neck
4.	Wounds and Injuries (Trauma)
5.	Necrosis

Experts

1.	Mitchell, James B: 7 articles (09/2014 - 03/2002)
2.	Alsner, Jan: 6 articles (01/2015 - 03/2008)
3.	Overgaard, Jens: 6 articles (01/2015 - 03/2008)
4.	Hauer-Jensen, Martin: 5 articles (01/2013 - 06/2002)
5.	Delanian, Sylvie: 5 articles (12/2012 - 07/2003)
6.	Delanian, S: 5 articles (12/2008 - 05/2000)
7.	Longaker, Michael T: 4 articles (01/2022 - 08/2014)
8.	Popanda, Odilia: 4 articles (05/2021 - 03/2016)
9.	Schmezer, Peter: 4 articles (05/2021 - 03/2016)
10.	Wang, Junru: 4 articles (01/2013 - 06/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Radiation Fibrosis Syndrome:

1.	Pentoxifylline (Trental)FDA LinkGeneric 06/01/2004 - "In an open label drug trial, we studied the effects of pentoxifylline (400 mg orally tid for 8 weeks) on 30 patients who displayed late, radiation-induced fibrosis at 1 to 29 years posttreatment (40 to 84 Gy). " 06/01/2004 - "Pentoxifylline in the treatment of radiation-induced fibrosis." 02/01/2023 - "Pentoxifylline has been used to treat various dermatological conditions including peripheral vascular disease, vasculitis and vasculopathies, chilblains, pigmented purpuric dermatosis, granuloma annulare, necrobiosis, keloids, lichen sclerosis et atrophicus, scars, radiation-induced fibrosis, vitiligo, alopecia areata, leishmaniasis, and leprosy. " 01/01/2001 - "Crux medicorum ulcerated radiation-induced fibrosis - successful therapy with pentoxifylline and vitamin E." 12/01/2012 - "It strengthens previous clinical data showing pentoxifylline-vitamin E synergy and supports its use as a first-line treatment of radiation-induced fibrosis."
2.	Vitamin EFDA LinkGeneric 01/01/2022 - "Fat Grafts Augmented With Vitamin E Improve Volume Retention and Radiation-Induced Fibrosis." 07/01/2004 - "It is concluded that post-irradiation vitamin E does not influence radiation-induced fibrosis to the lung." 01/01/2001 - "The treatment of radiation-induced fibrosis with PTX and vitamin E is a practicable and cost-effective regimen, especially for inoperable patients. " 03/01/2013 - "This study of postirradiation breast cancer patients treated with PTX/vitamin E or standard follow-up indicated a significant difference in radiation-induced fibrosis as measured by TCM. " 01/01/2001 - "Crux medicorum ulcerated radiation-induced fibrosis - successful therapy with pentoxifylline and vitamin E."
3.	AntioxidantsIBA 03/01/2001 - "As we previously observed that bovine liposomal Cu/Zn SOD (LipSOD) reduces cutaneous radiation-induced fibrosis (RIF) in human therapeutic assays the mechanisms involved were investigated here by an in vitro study of the LipSOD effects on cellular antioxidant metabolism and regulation of matrix degradation. " 12/01/2012 - "Promising treatments via the antioxidant pathway for radiation-induced fibrosis suggest a way to improve the everyday quality of life of these long-term cancer survivors." 10/09/2023 - "Anti-inflammatory and antioxidant therapies are the traditional treatments for radiation-induced fibrosis. " 07/01/1994 - "Based on experimental and clinical evidence indicating that the anti-oxidant agent liposomal Cu/Zn superoxide dismutase (Lipsod) is an effective anti-inflammatory drug and possibly might be effective in reducing late radiation-induced tissue injury, a clinical trial using Lipsod to treat long-standing radiation-induced fibrosis (RIF) was begun at the Necker Hospital, Paris in May 1984. " 01/01/2023 - "However, investigators more recently have posited that its angiogenic and antioxidant properties could be beneficial in treating the hypovascular and reactive-oxygen species-rich tissues seen in chronic wounds and radiation-induced fibrosis (RIF). "
4.	Superoxide DismutaseIBA 05/01/1996 - "Successful treatment of radiation-induced fibrosis using Cu/Zn-SOD and Mn-SOD: an experimental study." 01/01/1989 - "[Action of liposomal superoxide dismutase on measurable radiation-induced fibrosis]." 07/01/2016 - "Impact of Superoxide Dismutase-Gliadin on Radiation-induced Fibrosis: An Experimental Study." 05/01/1996 - "To establish how far liposomal copper/zinc superoxide dismutase (Cu/Zn-SOD) and manganese superoxide dismutase (Mn-SOD), respectively, reduce radiation-induced fibrosis (RIF), using a well-characterized pig model of RIF permitting the design of a controlled laboratory experiment. " 12/01/2012 - "Clinical therapeutic interventions for radiation fibrosis have included empirical treatments, such as antioxidant therapies using superoxide dismutase, or vitamin E and pentoxifylline, and although evidence for therapeutic efficacy exists, further randomised studies are required. "
5.	Transforming Growth Factor beta (TGF-beta)IBA 03/01/2010 - "Inhibiting the TGF-beta signaling pathway by various means has been shown to reduce radiation-induced fibrosis in pre-clinical studies. " 08/01/2009 - "Activation of the transforming growth factor-beta (TGF-beta) signaling pathway is thought to play a major role in radiation-induced fibrosis and has prompted the development and assessment of low molecular weight inhibitors of the pathway. " 03/01/2002 - "Transforming growth factor-beta (TGF-beta) plays a central role in the pathogenesis of inflammatory and fibrotic diseases, including radiation-induced fibrosis. " 11/01/2000 - "These data confirm the putative role of TGF-beta in intestinal radiation fibrosis." 05/01/2000 - "This review discusses recent evidence on the critical role played by TGF-beta in the initiation, development, and persistence of radiation fibrosis. "
6.	Reactive Oxygen Species (Oxygen Radicals)IBA 07/15/2013 - "SNP in TXNRD2 associated with radiation-induced fibrosis: a study of genetic variation in reactive oxygen species metabolism and signaling." 01/01/2019 - "Reactive Oxygen Species Drive Epigenetic Changes in Radiation-Induced Fibrosis." 01/01/2004 - "Similarly, germline variants in genes involved in DNA repair, radiation-induced fibrosis and reactive oxygen species may be used to predict response to radiation therapy. " 06/13/2023 - "The pathogenesis of ORN is complex, and includes vascular injury, mesenchymal stem cell injury, bone loss, reactive oxygen species, radiation-induced fibrosis, and cell senescence. " 01/01/2023 - "However, investigators more recently have posited that its angiogenic and antioxidant properties could be beneficial in treating the hypovascular and reactive-oxygen species-rich tissues seen in chronic wounds and radiation-induced fibrosis (RIF). "
7.	Pravastatin (Pravachol)FDA LinkGeneric 01/01/2020 - "[Pravastatin is capable to reduce radiation induced fibrosis after head-and-neck treatment]." 09/15/2007 - "Rho and ROCK activities were monitored in human explants presenting radiation fibrosis remodeling after incubation with pravastatin. " 01/01/2019 - "The "PRAVACUR" phase 2 trial (NCT01268202) assessed the efficacy of pravastatin as an antifibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiation therapy and/or radiochemotherapy. " 09/15/2007 - "Then, the therapeutic relevance of the antifibrotic action of pravastatin was explored in vivo in a rat model of chronic radiation fibrosis (19 Gy X-rays) treated with 30 mg/kg/d pravastatin in the drinking water. "
8.	Octreotide (Sandostatin)FDA LinkGeneric 04/01/2001 - "Octreotide confers dose-dependent protection against delayed small bowel radiation toxicity and ameliorates radiation fibrosis predominantly by reducing acute mucosal injury. " 04/01/2001 - "The present study addressed whether octreotide reduces chronic intestinal radiation fibrosis, whether enteroprotection is conferred by direct or indirect mechanisms, and whether the effects are dose-dependent. " 01/01/2008 - "Increased activity on In-111 octreotide imaging due to radiation fibrosis." 02/01/1997 - "Therefore, we believe that even in the case of prior external beam irradiation, mediastinal uptake of octreotide might represent metastatic MTC rather than radiation fibrosis."
9.	Ramipril (Altace)FDA LinkGeneric 01/01/2021 - "Our results show that ramipril reduces radiation-induced fibrosis and contracture. " 01/01/2021 - "The aim of this study is to evaluate the efficacy of ramipril for the prevention of radiation-induced fibrosis around the silicone implant. "
10.	SiliconesIBA 01/01/2021 - "The aim of this study is to evaluate the efficacy of ramipril for the prevention of radiation-induced fibrosis around the silicone implant. "

Therapies and Procedures

1.	Therapeutics 03/01/2022 - ": Deep Learning, Lung Fibrosis, Radiation Therapy, Segmentation, Animal Studies, CT, Thorax, Lung Supplemental material is available for this article. " 03/01/2004 - "It is hoped that the study of mechanisms that lead to the development of radiation fibrosis will point the way to possible future therapies. " 12/09/2022 - "Adipose-Derived Stromal Cell-Based Therapies for Radiation-Induced Fibrosis." 05/01/2021 - "Future approaches using advanced techniques such as FLASH therapy could provide even further benefit by reducing post-radiation fibrosis." 12/01/2019 - "Understanding the mechanism of radiation induced fibrosis and therapy options."
2.	Radiotherapy 10/01/2023 - "The ILR anastomosis is placed in a location thought to be outside the standard radiation therapy fields to prevent radiation-induced fibrosis of the reconstructed vessels; however, there is excess risk of BCRL from RNI even after ILR. " 01/01/2023 - "Chronic radiation fibrosis (CRF) is a long-term sequala of radiation therapy that has a significant impact on patient quality of life. " 09/01/2022 - "Radiation-induced fibrosis is a potentially severe late complication after high-dose radiotherapy. " 09/01/2022 - "Due to prior SBRT (stereotactic body radiation therapy) with dose levels causing radiation fibrosis, he was not a candidate for repeat SBRT, and he was not a surgical candidate due to comorbidities. " 03/19/2021 - "Radiation-induced fibrosis is a serious long-lasting side effect of radiation therapy. "
3.	Chemoradiotherapy 10/01/2018 - "Salvage endoscopic submucosal dissection (ESD) after chemoradiotherapy can be technically difficult as a result of radiation-induced fibrosis. " 09/01/2016 - "To investigate the incorporation of pretherapy regional ventilation function in predicting radiation fibrosis (RF) in stage III nonsmall cell lung cancer (NSCLC) patients treated with concurrent thoracic chemoradiotherapy. " 01/01/2019 - "The "PRAVACUR" phase 2 trial (NCT01268202) assessed the efficacy of pravastatin as an antifibrotic agent in patients with established cutaneous and subcutaneous radiation-induced fibrosis (RIF) after head and neck squamous cell carcinoma (HNSCC) radiation therapy and/or radiochemotherapy. "
4.	Brachytherapy 05/01/2013 - "Tissue compliance meter is a more reproducible method of measuring radiation-induced fibrosis than late effects of normal tissue-subjective objective management analytical in patients treated with intracavitary brachytherapy accelerated partial breast irradiation: results of a prospective trial." 11/01/2013 - "To assess pain rates and relationship to radiation-induced fibrosis (RIF) in patients treated with intracavitary brachytherapy accelerated partial breast irradiation (IBAPBI). " 11/01/1996 - "For 13 patients conventional salvage by partial debulking surgery and brachytherapy proved effective, with 68 per cent control at 1 year, but six patients suffered severe radiation fibrosis, necrosis and contractures. "
5.	Aftercare (After-Treatment) 01/01/2016 - "He developed left submandibular firmness five years after treatment, initially diagnosed as radiation-induced fibrosis. " 05/01/1991 - "The severity of radiation fibrosis was assessed clinically from CT scans 6 months and 12 months after treatment. " 10/01/2003 - "After treatment we evaluated the sensitivity of transrectal ultrasound in the differentiation of post-radiation fibrosis from residual tumor/local relapse (gold standard: histological analysis). " 10/01/2022 - "The endpoints were tumor control (TC) assessed as no recurrent tumor at 90 days after treatment, the level of acute moist desquamation (MD) to the skin of the foot within 25 days post irradiation, and radiation induced fibrosis (RIF) within 24 weeks post irradiation. " 11/01/1985 - "Spontaneous pneumothorax following thoracic irradiation tends to be recurrent, occasionally bilateral, and in most reported cases, occurs in patients who develop roentgenographic evidence of radiation fibrosis after treatment with mantle-shaped portals for Hodgkin's and non-Hodgkin's lymphomas. "