Three Finger Toxins

A super-family of non-enzymatic proteins found in ELAPIDAE VENOMS. They possess a unique tertiary structure resembling a hand with three fingers and have diverse biological activities due to sequence and structural variations; some are ALPHA-NEUROTOXINS that bind NICOTINIC ACETYLCHOLINE RECEPTORS.

Also Known As:

Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Tan, Choo Hock: 2 articles (01/2019 - 10/2015)
2.	Tan, Kae Yi: 2 articles (01/2019 - 10/2015)
3.	Tan, Nget Hong: 2 articles (01/2019 - 10/2015)
4.	Gutiérrez, José María: 2 articles (01/2018 - 10/2014)
5.	Calvete, Juan J: 2 articles (10/2014 - 08/2011)
6.	Sanz, Libia: 2 articles (10/2014 - 08/2011)
7.	Boddum, Kim: 1 article (01/2022)
8.	Friis, Rasmus: 1 article (01/2022)
9.	Laustsen, Andreas H: 1 article (01/2022)
10.	Ledsgaard, Line: 1 article (01/2022)

Related Diseases

1.	Infections 12/16/2021 - "This study highlights the impact of snake venoms and their fractions on controlling protozoal infections and suggests the need to examine further the effectiveness of other venom components, such as metalloproteinase, serine protease and three-finger toxins. "
2.	Paralysis (Palsy) 01/01/2019 - "In the three-finger toxin family, the alpha-neurotoxins comprise solely short neurotoxins (SNTX, 44.55%), supporting that SNTX is the principal toxin responsible for neuromuscular paralysis and lethality reported in clinical envenomation. " 10/14/2023 - "These neurotoxic envenomations are characterized by neuromuscular paralysis attributed to venom components such as three-finger toxins (3FTx) and phospholipases (PLA2). " 01/01/2022 - "These incidents often result in death due to paralysis caused by α-neurotoxins from the three-finger toxin (3FTx) family, which are abundant in elapid venoms. " 10/01/2015 - "Neurotoxins comprise the major 3FTxs in the MOh venom, consistent with rapid neuromuscular paralysis reported in systemic envenoming. " 01/01/2019 - "Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (nAChRs). "
3.	Snake Bites (Snake Bite) 10/01/2021 - "Administration of the antivenom is the recommended treatment for the snakebite envenomings, while the efficacy to cross-neutralize the different cobra species is typically limited, which is presumably due to intra-specific variation of the 3FTXs composition in cobra venoms. " 01/01/2019 - "Neurotoxic snake venoms contain small neurotoxins, including three-finger toxins (3FTxs), which can cause rapid paralysis in snakebite victims by blocking postsynaptic transmission via nicotinic acetylcholine receptors (nAChRs). "
4.	Pain (Aches) 01/01/2018 - "Mambalgins, a family of three-finger toxins isolated from black mamba venom, specifically inhibit ASICs to exert strong analgesic effects in vivo, thus are thought to have potential therapeutic values against pain. " 01/01/2021 - "Acid-sensing ion channels (ASICs) are proton-gated cationic channels involved in pain and other processes, underscoring the potential therapeutic value of specific inhibitors such as the three-finger toxin mambalgin-1 (Mamb-1) from snake venom. "
5.	Myotoxicity 01/01/2018 - "3FTxs are the main responsible for lethality and myotoxicity in mice and in vitro anticoagulant activity. " 10/14/2014 - "We have investigated the contribution of 3FTxs and PLA₂ molecules in venom lethality, myotoxicity, and cardiovascular function. "

Related Drugs and Biologics

1.	Venoms
2.	Snake Venoms (Snake Venom)
3.	Serine Proteases (Serine Protease)
4.	Metalloproteases (Metalloproteinases)
5.	Neurotoxins
6.	Cardiotoxins
7.	Elapid Venoms (Cobra Venom)
8.	Three Finger Toxins
9.	Sodium Channel Agonists
10.	Acid Sensing Ion Channels