Semicircular Canal Dehiscence

A vestibular disorder caused by a pathologic third window into the BONY LABYRINTH (in contrast to the normal ROUND WINDOW OF EAR and the OVAL WINDOW OF EAR). It can present with autophony, sound- or pressure-induced VERTIGO, and chronic disequilibrium among other vestibulocochlear symptoms.(From: Semin Neurol. 2020 Jan 27; 48: 58-65.)

Also Known As:

Dehiscence of the Lateral Semicircular Canal; Dehiscence of the Posterior Semicircular Canal; Dehiscence of the Semicircular Canal; Dehiscence of the Superior Semicircular Canal; Lateral Canal Dehiscence Syndrome; Lateral Semicircular Canal Dehiscence; Lateral Semicircular Canal Dehiscence Syndrome; Posterior Canal Dehiscence Syndrome; Posterior Semicircular Canal Dehiscence; Posterior Semicircular Canal Dehiscence Syndrome; Semicircular Canal Dehiscence Syndrome; Superior Canal Dehiscence Syndrome; Superior Semicircular Canal Dehiscence; Superior Semicircular Canal Dehiscence Syndrome

Networked: 68 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Otorhinolaryngologic Diseases: 203
- Ear Diseases: 261
  - Labyrinth Diseases: 309
    - Vestibular Diseases: 47
      - Semicircular Canal Dehiscence: 68

Related Diseases

1.	Otosclerosis
2.	Hearing Loss (Hearing Impairment)
3.	Hypersensitivity (Allergy)
4.	Mixed Conductive-Sensorineural Hearing Loss
5.	Vertigo (Positional Vertigo)

Experts

1.	Gopen, Quinton: 8 articles (10/2022 - 11/2016)
2.	Yang, Isaac: 8 articles (10/2022 - 11/2016)
3.	Carey, John P: 6 articles (10/2019 - 06/2009)
4.	Duong, Courtney: 4 articles (12/2021 - 06/2019)
5.	Wackym, P Ashley: 3 articles (10/2021 - 08/2015)
6.	Ward, Bryan K: 3 articles (10/2019 - 01/2016)
7.	Chung, Lawrance K: 3 articles (09/2017 - 11/2016)
8.	Ung, Nolan: 3 articles (09/2017 - 11/2016)
9.	Mekonnen, Mahlet: 2 articles (10/2022 - 12/2021)
10.	Hatton, Kelsey: 2 articles (07/2022 - 01/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Semicircular Canal Dehiscence:

1.	Capsules (Microcapsules)IBA 01/01/2023 - "Superior semicircular canal dehiscence (SSCD) is a vestibular-cochlear disorder in humans in which a pathological third mobile window of the otic capsule creates changes to the flow of sound pressure energy through the perilymph/endolymph. " 01/01/2023 - "Why should multiple dehiscences of the otic capsule be considered before surgically treating patients with superior semicircular canal dehiscence? " 12/01/2021 - "Superior semicircular canal dehiscence (SSCD) is an abnormality of the otic capsule, which normally overlies the superior semicircular canal. " 01/01/2020 - "When the superior semicircular canal dehiscence is associated to other in the petrous bone (tegmen tympani, mastoid antrum, posterior semicircular canal, internal auditory canal) could be grouped into the same syndrome called "otic capsule syndrome", since they have the same origin and common aetiology (otic capsule)." 01/01/2019 - "Semicircular canal dehiscence is a bony abnormality in the otic capsule especially involving the superior semicircular canal. "
2.	Indicators and Reagents (Reagents)IBA 07/01/2013 - "An indicator of probable semicircular canal dehiscence: ocular vestibular evoked myogenic potentials to high frequencies." 01/01/2022 - "An enhanced response on vestibular evoked myogenic potential testing in isolation appears to be a weaker indicator of superior canal dehiscence syndrome, and rather a marker of superior semicircular canal dehiscence." 05/01/2014 - "Ocular vestibular evoked myogenic potentials n10 response in autism spectrum disorders children with auditory hypersensitivity: an indicator of semicircular canal dehiscence."
3.	Vitamin D FDA LinkGeneric 01/01/2023 - "Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study."
4.	TitaniumIBA 10/01/2019 - "To discuss an effect of transmastoid repair of superior semicircular canal dehiscence and its resolution using a mastoid titanium mesh plate. "
5.	SteroidsIBA 01/01/2021 - "After treatment with mastoidectomy and steroids, she subsequently developed superior semicircular canal dehiscence syndrome. "
6.	CalciumIBA 01/01/2023 - "It remains unknown whether calcium metabolism has any effect on the clinical presentation of superior semicircular canal dehiscence (SSCD). " 01/01/2023 - "Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study."
7.	Netrin-1IBA 10/01/2012 - "Mutation analysis of Netrin 1 and HMX3 genes in patients with superior semicircular canal dehiscence syndrome."
8.	hydroxyapatite cementIBA 06/01/2014 - "Surgical plugging and resurfacing are well established treatments of superior semicircular canal dehiscence, while capping with hydroxyapatite cement has been little discussed in literature. "
9.	calcium phosphateIBA 06/01/2011 - "[Superior semicircular canal dehiscence syndrome treated by calcium phosphate cement canal plugging: a case report]."
10.	2-toluenesulfonamide (OTS)IBA 01/01/2021 - "Concomitant otosclerosis (OTS) and superior semicircular canal dehiscence (SSCD) is a rare, but difficult-to-identify and treat diagnosis. "

Therapies and Procedures

1.	Craniotomy 06/28/2019 - "Sealing of superior semicircular canal dehiscence is associated with improved balance outcomes postoperatively versus plugging of the canal in middle fossa craniotomy repairs: a case series." 11/01/2021 - "This study prospectively administered selective scalp blocks (lesser occipital, preauricular nerve block + pin site block) in 20 consecutive patients undergoing craniotomy for semicircular canal dehiscence. " 07/01/2012 - "Patients included in this study were diagnosed with superior semicircular canal dehiscence syndrome and underwent surgical repair of the dehiscence through middle fossa craniotomy. " 06/01/2022 - "This video presentation aimed to demonstrate endoscopic-assisted repair of superior semicircular canal dehiscence with middle fossa craniotomy. " 06/01/2022 - "Superior semicircular canal dehiscence repair with small middle fossa craniotomy using an oto-microscopic and co-endoscopic assisted approach."
2.	Stapes Surgery (Stapedectomy) 12/01/2018 - "Computed tomography scan should be performed as a routine before every stapes surgery, in order to exclude concomitant superior semicircular canal dehiscence, since no other clinical, audiological, or electro-physiological criteria are available to exclude concomitant superior semicircular canal dehiscence in the otosclerotic temporal bone." 04/01/2010 - "The diagnosis of superior canal dehiscence syndrome should be considered in patients with persistent audiovestibular symptoms after stapes surgery. " 06/01/2014 - "Of particular note, superior semicircular canal dehiscence is an important contraindication to stapes surgery." 01/01/2020 - "To review outcomes of stapes surgery in patients with concurrent otosclerosis and superior semicircular canal dehiscence. " 01/01/2020 - "Stapes Surgery Outcomes in Patients With Concurrent Otosclerosis and Superior Semicircular Canal Dehiscence."
3.	Ossicular Prosthesis (TORP) 10/01/2021 - "Nine illustrative cases which demonstrate conditions such as persistent stapedial artery, membranous stapes footplate, total ossicular prosthesis migration into the vestibule, third window syndrome such as superior semicircular canal dehiscence (SSCD) and cochlea-facial nerve dehiscence, otosclerosis, and ossicular chain discontinuity are included. " 01/01/2021 - "This review illustrates key imaging findings after surgery for Ménière disease, superior semicircular canal dehiscence, temporal encephalocele repairs, internal auditory canal decompression, active middle ear implants, jugular bulb and sigmoid sinus dehiscence repair, and petrous apicectomy." 01/01/2020 - "The aim of the present study is to report the outcomes of round window reinforcement surgery performed with the application of a Vibrant Soundbridge middle ear implant (VSB; MED-EL) in a patient with superior semicircular canal dehiscence (SSCD) who presented with recurrent vertigo, Tullio phenomenon, Hennebert's sign, bone conduction hypersensitivity, and bilateral moderate to severe mixed hearing loss. "
4.	Lasers (Laser) 05/01/2004 - "Four investigations were performed: 1) laser-Doppler vibrometer measurements of sound-induced umbo velocity in patients with computed tomographic scan-confirmed superior semicircular canal dehiscence; 2) laser-Doppler vibrometry of sound-induced motions of the vestibular lymph (either perilymph or endolymph) exposed in a chinchilla model of superior semicircular canal dehiscence; 3) studies in chinchillas of the effect of superior semicircular canal dehiscence on the cochlea's sensitivity to bone-conducted sounds; and 4) anatomically based theoretical analyses of sound flow through the human cochlea and semicircular canals. "
5.	Contraindications 06/01/2014 - "Of particular note, superior semicircular canal dehiscence is an important contraindication to stapes surgery." 01/01/2022 - "RESPONSE TO LETTER TO THE EDITOR: "OUTCOMES OF STAPEDOTOMY IN PATIENTS WITH CONCOMITANT OTOSCLEROSIS AND SUPERIOR SEMICIRCULAR CANAL DEHISCENCE: SHOULD A RADIOGRAPHIC THIRD-WINDOW BE A CONTRAINDICATION TO STAPES SURGERY?"" 01/01/2022 - "TO THE EDITOR: "OUTCOMES OF STAPEDOTOMY IN PATIENTS WITH CONCOMITANT OTOSCLEROSIS AND SUPERIOR SEMICIRCULAR CANAL DEHISCENCE: SHOULD A RADIOGRAPHIC THIRD-WINDOW BE A CONTRAINDICATION TO STAPES SURGERY?"" 01/01/2022 - "Radiographic superior semicircular canal dehiscence may not be an absolute contraindication to stapes surgery for otosclerosis." 01/01/2022 - "Outcomes of Stapedotomy in Patients With Concomitant Otosclerosis and Superior Semicircular Canal Dehiscence: Should a Radiographic Third-Window Be a Contraindication to Stapes Surgery?"