Mast Cell Stabilizers

Compounds that prevent the release of inflammatory mediators from MAST CELLS.

Also Known As:

Cell Stabilizer, Mast; Cells Stabilizer, Mast; Stabilizer, Mast Cell; Stabilizer, Mast Cells; Stabilizers, Mast Cell; Stabilizers, Mast Cells; Mast Cell Degranulation Stabilizer; Mast Cell Degranulation Stabilizers; Mast Cell Stabilizer; Mast Cell Stabilizing Compound; Mast Cell Stabilizing Compounds; Mast Cells Degranulation Stabilizer; Mast Cells Degranulation Stabilizers; Mast Cells Stabilizer; Mast Cells Stabilizers

Networked: 216 relevant articles (17 outcomes, 25 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Therapeutic Uses: 47080
    - Anti-Inflammatory Agents: 4247
      - Mast Cell Stabilizers: 216
    - Anti-Allergic Agents: 1733
      - Mast Cell Stabilizers: 216
  - Physiological Effects of Drugs: 1
    - Immunologic Factors: 7984
      - Mast Cell Stabilizers: 216

Experts

1.	Hildebrand, Kevin A: 5 articles (01/2021 - 03/2008)
2.	Hart, David A: 4 articles (01/2021 - 03/2008)
3.	Abelson, Mark B: 4 articles (11/2008 - 07/2002)
4.	Kazama, Itsuro: 3 articles (12/2021 - 09/2015)
5.	Befus, A Dean: 3 articles (01/2021 - 06/2010)
6.	Salo, Paul T: 3 articles (01/2021 - 06/2010)
7.	Singh, Nirmal: 3 articles (05/2018 - 10/2017)
8.	Boeckxstaens, G E: 3 articles (12/2013 - 01/2006)
9.	Kari, Osmo: 3 articles (06/2012 - 01/2010)
10.	Saari, K Matti: 3 articles (06/2012 - 01/2010)

Related Diseases

1.	Allergic Conjunctivitis (Giant Papillary Conjunctivitis) 01/01/2022 - "Topical mast cell stabilizers were previously shown to treat the signs and symptoms of seasonal and perennial allergic conjunctivitis safely and effectively in active and placebo-controlled trials. " 01/01/2007 - "Mast cell stabilizers for the relief of allergic conjunctivitis." 10/01/2018 - "To address the current trends of therapeutic mechanisms for treatment of allergic conjunctivitis (AC), based on topical antihistamines and mast cell stabilizers (MCS). " 06/01/2016 - "Topical Antihistamines and Mast Cell Stabilizers for Treating Allergic Conjunctivitis." 10/23/2013 - "Treatment with antihistamines and mast cell stabilizers alleviates the symptoms of allergic conjunctivitis."
2.	Contracture 03/01/2022 - "The use of the mast cell stabilizer KF within 2 weeks of injury demonstrated a nonsignificant trend towards reducing joint contracture in a rabbit in vivo model of PTJC. " 04/01/2012 - "Using a rabbit model of post-traumatic joint contractures, we investigated whether treatment with a mast cell stabilizer after joint injury would lessen the molecular manifestations of joint capsule fibrosis. " 01/01/2021 - "In prior studies using an established in vivo model, we found that ketotifen fumarate (KF), a mast cell stabilizer, was associated with a significant reduction in the severity of posttraumatic joint contracture. " 01/01/2021 - "The Dose-Response Effect of the Mast Cell Stabilizer Ketotifen Fumarate on Posttraumatic Joint Contracture: An in Vivo Study in a Rabbit Model." 06/01/2020 - "The present study used a previously described and validated rabbit model to assess the biomechanical, histopathological, and molecular effects of the mast cell stabilizer ketotifen on surgically induced knee joint contractures in female rabbits. "
3.	Hypersensitivity (Allergy) 01/01/2021 - "Mast cell stabilizers are an essential part of allergy medication. " 01/01/2016 - "Mast cell stabilizers as well as PAR-2 antagonist agents may be useful for treatment of allergic reactions. " 01/01/1986 - "Ocular allergy and mast cell stabilizers." 10/01/2011 - "New pharmacological agents, including more potent mast cell stabilizers, and low-dose corticosteroids, have improved the efficacy and safety of ocular allergy treatment. " 11/01/1998 - "Mast cell stabilizers such as sodium cromoglycate are both safe and effective and are commonly used in ocular allergy. "
4.	Pruritus (Itching) 01/01/1994 - "Accordingly, mast cell stabilizers are claimed to reduce proliferation and itching of neurofibromas. " 04/01/2006 - "Two patients with disabling uremic pruritus refractory to multiple interventions are reported, who showed significant improvement in pruritus severity as assessed by a visual analog scale when they were treated with the mast cell stabilizer cromolyn sodium. " 12/01/1991 - "We further examined the effects of ketotifen, a putative mast cell stabilizer, on severe uremic pruritus. " 01/01/2023 - "The Investigation of Therapeutic Implications of Mast Cell Stabilizer Cromolyn Sodium on Cholestasis and Cholestatic Pruritus in Experimental Cholestasis." 06/01/2007 - "Both are H(1) antihistamine/mast cell stabilizers indicated for the treatment of ocular itching associated with allergic conjunctivitis. "
5.	Wounds and Injuries (Trauma) 03/01/2008 - "Immediately following the creation of full-thickness excisional wounds, the mast cell stabilizer ketotifen was used to treat both Yorkshire and red Durocs. " 01/01/1990 - "The mast cell stabilizer injected directly into wounds decreased collagen content, especially on 10th and 14th day of the healing process." 01/01/1990 - "Disodium cromoglycate (a mast cell stabilizer) administered to the rats in a dose of 2 mg/animal was found to retard wound healing and markedly increased wound surface in all examined days (3rd, 5th, 7th, 10th, 14th day of healing). " 03/01/2008 - "The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs." 06/01/2004 - "An experimental study was performed to investigate the efficacy of ketotifen, which is a mast cell stabilizer and histamine H(1)-receptor antagonist, on the prevention of stricture development after esophageal caustic injuries in the rat. "

Related Drugs and Biologics

1.	Ketotifen (Ketotifene)
2.	Histamine Antagonists (Antihistamines)
3.	Cromolyn Sodium (Cromoglicic Acid)
4.	lodoxamide ethyl (lodoxamide)
5.	Histamine (Histamine Dihydrochloride)
6.	Anti-Allergic Agents (Antiallergic Agents)
7.	Ophthalmic Solutions (Eye Drops)
8.	Nedocromil (Alocril)
9.	Adrenal Cortex Hormones (Corticosteroids)
10.	Steroids

Related Therapies and Procedures

1.	Therapeutics
2.	Intraperitoneal Injections
3.	Immunotherapy
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration