Acute Hemorrhagic Pancreatitis

An acute INFLAMMATION of the PANCREAS in which the initial edematous pancreatitis evolved into necrosis accompanied by HEMORRHAGE.

Also Known As:

Pancreatitis, Acute Hemorrhagic; Acute Hemorrhagic Pancreatitides; Hemorrhagic Pancreatitides; Hemorrhagic Pancreatitides, Acute; Hemorrhagic Pancreatitis, Acute; Pancreatitides, Acute Hemorrhagic; Pancreatitides, Hemorrhagic; Pancreatitis, Hemorrhagic; Hemorrhagic Pancreatitis

Networked: 320 relevant articles (6 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Digestive System Diseases: 1042
- Pancreatic Diseases: 1635
  - Pancreatitis: 23128
    - Acute Hemorrhagic Pancreatitis: 320

Related Diseases

1.	Gallstones (Gallstone)
2.	Jaundice (Icterus)
3.	Inflammation (Inflammations)
4.	Pancreatitis
5.	Necrosis

Experts

1.	Otsuki, Makoto: 2 articles (07/2015 - 11/2007)
2.	Takeyama, Yoshifumi: 2 articles (04/2006 - 01/2002)
3.	Ceranowicz, P: 2 articles (12/2004 - 06/2002)
4.	Konturek, S J: 2 articles (12/2004 - 06/2002)
5.	Warzecha, Z: 2 articles (12/2004 - 06/2002)
6.	Chang, Stephanie H: 1 article (08/2022)
7.	Chaux, George E: 1 article (08/2022)
8.	Choe, June: 1 article (08/2022)
9.	Chung, Alice P: 1 article (08/2022)
10.	Falk, Jeremy A: 1 article (08/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acute Hemorrhagic Pancreatitis:

1.	Indomethacin (Indometacin)FDA LinkGeneric 01/01/1989 - "Acute hemorrhagic pancreatitis in mice: improved survival after indomethacin administration." 01/01/1988 - "The effects of indomethacin administration on hemodynamics were investigated in canine acute hemorrhagic pancreatitis (AHP). " 01/01/1988 - "Indomethacin in canine acute hemorrhagic pancreatitis." 01/01/1989 - "The results suggest that prostaglandins may play an important role in the pathogenesis of acute hemorrhagic pancreatitis, and that indomethacin attenuates the severity of the induced disease." 01/01/1989 - "This study was designed to test whether indomethacin given in drinking water attenuates the severity of the acute hemorrhagic pancreatitis induced in mice fed a choline-deficient ethionine diet (CDE), and improves their survival. "
2.	Arginine (L-Arginine)FDA Link 10/01/1995 - "L-Arginine ameliorated the severity of hemorrhagic pancreatitis dose dependently and improved the pancreatic blood flow. " 10/01/1995 - "L-Arginine (125 or 250 mg/kg), a NO donor was intravenously administered twice in the rats with hemorrhagic pancreatitis induced by water-immersion stress plus two intraperitoneal injections of cerulein (40 micrograms/kg). " 01/01/1999 - "However, the results obtained with CCK or CCKA receptor antagonists in different species (rats, mice) and different models of acute pancreatitis (cerulein pancreatitis, hemorrhagic pancreatitis induced by choline-deficient, ethionine-supplemented diet, arginine-induced pancreatitis, sodium taurocholate-induced pancreatitis) produced variable results. "
3.	Endothelin Receptor AntagonistsIBA 08/01/1997 - "An ETa/ETb endothelin antagonist ameliorates systemic inflammation in a murine model of acute hemorrhagic pancreatitis."
4.	lexipafantIBA 02/01/1999 - "Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis."
5.	EthionineIBA 01/01/2002 - "The administration of ethionine by feeding to mice in a choline-sufficient diet caused a lower incidence of acute hemorrhagic pancreatitis than in mice given a choline-deficient diet. " 01/01/1995 - "Ethionine, an inhibitor of cellular methylation reactions, produces hemorrhagic pancreatitis when administered to mice fed a choline-deficient diet. " 01/01/1992 - "(b) Hemorrhagic pancreatitis was induced by feeding a choline-deficient, ethionine-supplemented (CDE) diet in mice. " 05/01/1991 - "Hemorrhagic pancreatitis was induced by feeding a choline-deficient, ethionine-supplemented (CDE) diet to mice for 66 h. " 05/01/1986 - "Young female mice fed a choline-deficient, ethionine-supplemented (CDE) diet rapidly develop acute hemorrhagic pancreatitis. "
6.	Choline (Choline Chloride)IBA 01/01/2002 - "The administration of ethionine by feeding to mice in a choline-sufficient diet caused a lower incidence of acute hemorrhagic pancreatitis than in mice given a choline-deficient diet. " 01/01/1995 - "Ethionine, an inhibitor of cellular methylation reactions, produces hemorrhagic pancreatitis when administered to mice fed a choline-deficient diet. " 01/01/1992 - "(b) Hemorrhagic pancreatitis was induced by feeding a choline-deficient, ethionine-supplemented (CDE) diet in mice. " 05/01/1991 - "Hemorrhagic pancreatitis was induced by feeding a choline-deficient, ethionine-supplemented (CDE) diet to mice for 66 h. " 05/01/1986 - "Young female mice fed a choline-deficient, ethionine-supplemented (CDE) diet rapidly develop acute hemorrhagic pancreatitis. "
7.	Taurocholic Acid (Sodium Taurocholate)IBA 04/01/2000 - "Necrotizing hemorrhagic pancreatitis was induced in male Wistar rats with sodium taurocholate. " 03/01/1999 - "Necrotizing hemorrhagic pancreatitis was induced with sodium taurocholate. " 04/01/1995 - "Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. " 04/01/1993 - "As measured by this assay, the concentration of pancreatic PLA2 in plasma was found to be above normal in rats with hemorrhagic pancreatitis induced by an intraductal injection of sodium taurocholate. " 12/01/1992 - "The histologically verified hemorrhagic pancreatitis was induced in Wistar rats (n = 66) by injecting 6% sodium taurocholate into the pancreatic duct. "
8.	CeruletideIBA 01/01/1996 - "Acute hemorrhagic pancreatitis was induced in rats by two intraperitoneal cerulein injection (20 micrograms/kg BW) with 5h water-immersion stress once a day for successive 3 days. " 06/01/1990 - "Acute hemorrhagic pancreatitis was induced by two intraperitoneal injections of cerulein (40 micrograms/kg body wt) at intervals of 1 h under water-immersion stress for 5 h, whereas water-immersion stress alone did not induce any morphologic and enzymatic changes in the pancreas. " 06/01/1994 - "Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. " 01/01/1994 - "Five hours after the first injection of cerulein, marked hemorrhage and venous dilatation were observed only in those with hemorrhagic pancreatitis. " 01/01/1994 - "Hemorrhagic pancreatitis was produced by administering two intraperitoneal doses of cerulein [40 micrograms/kg body weight (BW)] at 1-h intervals following water immersion stress applied for 5 h. "
9.	TrypsinIBA 01/01/1998 - "Acute hemorrhagic pancreatitis was induced by the injection of a mixture of autologous bile and porcine trypsin into the main pancreatic duct. " 07/01/1984 - "Severe necrotico-hemorrhagic pancreatitis was produced by intraductal injection of trypsin. " 09/01/1979 - "An experimental method was developed for the production of acute hemorrhagic pancreatitis of uniform lethality in dogs, using the injection of a bile trypsin mixture into the major pancreatic duct. " 07/10/1971 - "[The role of trypsin in the secondary manifestations of acute hemorrhagic pancreatitis]." 01/01/1968 - "[Evidence of the presence of trypsin in peripheral blood during acute hemorrhagic pancreatitis. "
10.	Trypsin InhibitorsIBA 01/01/1961 - "Study of the effect of trypsin inhibitor in acute hemorrhagic pancreatitis in dogs." 08/01/1964 - "TRYPSIN INHIBITOR IN ACUTE HEMORRHAGIC PANCREATITIS IN DOGS; EFFECT." 05/01/1953 - "Use of crystalline soybean trypsin inhibitor in acute hemorrhagic pancreatitis in dogs." 02/01/1992 - "The effect of FUT-175, a new synthetic trypsin inhibitor, was evaluated in a lethal model of acute hemorrhagic pancreatitis induced by feeding mice a choline-deficient, ethionine-supplemented diet (CDE diet). " 04/01/1982 - "Consequently, phospholipase and trypsin are released to the circulation during hemorrhagic pancreatitis, but the increase in trypsin is compensated for by an increase in trypsin-inhibitor capacity of serum due to elevated alpha 1-antitrypsin levels. "

Therapies and Procedures

1.	Therapeutics 06/01/1987 - "Peritoneal lavage combined with volume therapy in porcine hemorrhagic pancreatitis. " 07/01/1979 - "Evaluation of gamma radiation therapy in experimentally induced hemorrhagic pancreatitis in dogs." 08/01/1976 - "Surgical treatment has been used in those patients with hemorrhagic pancreatitis who deteriorate after several days of intensive medical therapy, or in those patients in whom the diagnosis cannot be established early in the course of treatment. " 03/01/1974 - "[Drying-up therapy in the treatment of acute necrotic-hemorrhagic pancreatitis. " 07/01/1973 - "Peritoneal lavage therapy in hemorrhagic pancreatitis."
2.	Pancreatectomy 01/01/1978 - "A patient with acute hemorrhagic pancreatitis treated successfully with total pancreatectomy is reported. " 10/01/1985 - "[Child's subtotal pancreatectomy in the treatment of acute necrotico-hemorrhagic pancreatitis. " 06/01/1985 - "Hemorrhagic pancreatitis: a complication of transcatheter embolization treated successfully by total pancreatectomy." 08/01/1982 - "[Preliminary experience in subcervical pancreatectomy in the treatment of acute hemorrhagic pancreatitis]." 01/01/1978 - "Though near total pancreatectomy remains the best surgical treatment in patients with acute hemorrhagic pancreatitis dying from the disease because of failure of nonoperative treatment, total pancreatectomy may be considered as an alternative if circumstances so indicate."
3.	Jejunostomy 12/01/1989 - "[Continuous enteral feeding in acute necrotic-hemorrhagic pancreatitis: apropos of 17 cases of jejunostomy]." 08/01/1976 - "Initial therapy consisted of: cholecystostomy or T-tube drainage in those patients who have gallstones, jaundice, or distended biliary tree; gastrostomy for prolonged gastric decompression; jejunostomy to provide a portal for enteroalimentation; and appropriate soft rubber drainage of the pancreatic bed as a simple, safe, and effective means of treating severe hemorrhagic pancreatitis. "
4.	Decompression 05/01/1986 - "The absence of any significant differences in hemodynamic status, histopathological findings, and biochemical analysis in our pigs, if translatable to man, does not lend support to early operative intervention in gallstone pancreatitis in the hope that those patients who already have hemorrhagic pancreatitis will benefit from early pancreatic ductal decompression." 08/01/1976 - "Initial therapy consisted of: cholecystostomy or T-tube drainage in those patients who have gallstones, jaundice, or distended biliary tree; gastrostomy for prolonged gastric decompression; jejunostomy to provide a portal for enteroalimentation; and appropriate soft rubber drainage of the pancreatic bed as a simple, safe, and effective means of treating severe hemorrhagic pancreatitis. "
5.	Gastrostomy 08/01/1976 - "Initial therapy consisted of: cholecystostomy or T-tube drainage in those patients who have gallstones, jaundice, or distended biliary tree; gastrostomy for prolonged gastric decompression; jejunostomy to provide a portal for enteroalimentation; and appropriate soft rubber drainage of the pancreatic bed as a simple, safe, and effective means of treating severe hemorrhagic pancreatitis. "