Evaluation of gamma radiation therapy in experimentally induced hemorrhagic pancreatitis in dogs.

Abstract

Acute bile-trypsin pancreatitis was induced in two groups of six dogs each. One group was given supportive treatment only; the second group was treated with irradiation of the pancreas (400 rad). A third group of six dogs was irradiated, but pancreatitis was not induced. A 13-fold increase in survival time was observed in the dogs with pancreatitis which had been irradiated. Irradiation alone was found to reduce the volume of pancreatic secretion with a relative increase in trypsin content. Modification of the inflammatory reaction by irradiation and reduction in pancreatic secretion probably account for the therapeutic effect.

• Authors: B E Musa, H L Ferguson, A W Nelson, E L Gillette, W V Lumb
• Journal: American journal of veterinary research (Am J Vet Res) Vol. 40 Issue 7 Pg. 927-30 (Jul 1979) ISSN: 0002-9645 [Print] United States
• PMID: 507495 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Lipase
• Amylases
• Trypsin

Topics

• Acute Disease
• Amylases (blood)
• Animals
• Dog Diseases (pathology, radiotherapy)
• Dogs
• Gamma Rays
• Hemorrhage (pathology, radiotherapy, veterinary)
• Lipase (blood)
• Pancreas (metabolism, pathology)
• Pancreatitis (pathology, radiotherapy, veterinary)
• Trypsin (metabolism)