Lactate Dehydrogenase 5

A member of the LACTATE DEHYDROGENASES isozyme family, Lactate Dehydrogenase 5 is localized to liver and skeletal muscle cells where its expression increases in liver disease and striated muscle trauma respectively.

Also Known As:

Networked: 659 relevant articles (16 outcomes, 57 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Granchi, Carlotta: 11 articles (02/2022 - 03/2011)
2.	Minutolo, Filippo: 11 articles (02/2022 - 03/2011)
3.	Di Stefano, Giuseppina: 10 articles (01/2022 - 01/2013)
4.	Koukourakis, Michael I: 10 articles (01/2016 - 01/2005)
5.	Seth, Pankaj: 9 articles (01/2021 - 03/2009)
6.	Giatromanolaki, Alexandra: 9 articles (01/2016 - 01/2005)
7.	Sivridis, Efthimios: 9 articles (01/2016 - 01/2005)
8.	Manerba, Marcella: 8 articles (01/2021 - 09/2013)
9.	Serganova, Inna: 7 articles (05/2022 - 10/2011)
10.	Kreutz, Marina: 7 articles (01/2021 - 08/2009)

Related Diseases

1.	Neoplasms (Cancer) 04/27/2021 - "There was significant reduction in LDH-A (P < 0.001) and cell viability (P < 0.001) in a dose-dependent mode in both HeLa and MCF-7 SO-treated cancer cells. " 09/01/2020 - "Earlier, we demonstrated the efficacy of N-hydroxyindole-based LDH-A inhibitors in different cancer types. " 08/01/2013 - "NK cells from LDH-A-depleted tumors had improved cytolytic function. " 04/27/2021 - "In this study, we have investigated the effect of inhibition of LDH-A on cells viability and identifying the mechanism of cell death in HeLa and MCF-7 cancer cells. " 12/01/2017 - "Previous studies have indicated that high expression of lactate dehydrogenase A (LDHA) exists in many human cancers. "
2.	Hypoxia (Hypoxemia) 08/18/2022 - "The study uncovered HIF-1/LDH-A signaling pathway responsive mechanisms of Japanese flounder to hypoxia in epigenetic modification and transcriptional regulation. " 01/01/2020 - "This study provides novel insights into hypoxia/PCFT-dependent chemoresistance, unravelling the potential prognostic value of LDH-A, and demonstrating the preclinical activity of LDH-A inhibitors." 01/01/2020 - "To validate proteomic studies, the effect of RT on HIF-1α, miR-210, PDH-A and LDH-A levels under hypoxia was assessed by qRT-PCR. " 04/01/2011 - "In the present study, we have cloned, sequenced and examined the modulation of the LDH-A gene after an Amazonian fish species, Astronotus crassipinis (the Oscar), was exposed to hypoxia and anoxia. " 05/01/2003 - "Our study demonstrates that, unlike what has been shown in cellular models under severe hypoxia, LDH A gene is not systematically up-regulated in tissues of rats living at high altitude. "
3.	Melanoma (Melanoma, Malignant) 01/01/2020 - "Furthermore, GLUT1 expression in human melanoma tissue samples correlated significantly with HK1, LDH-A and MCT1 expression, confirming a glycolytic phenotype. " 01/01/2018 - "Expression of HIF-1α and MCT4 was high, which might be a consequence of increased lactate dehydrogenase A levels in melanomas. " 03/29/2019 - "Anti-PD-1 treatment of mice harboring LDH-A deficient B16-F10 melanoma tumors led to an increase in anti-tumor immune responses compared to mice implanted with tumors expressing LDH-A. " 10/01/2015 - "Melanoma brain metastasis is independent of lactate dehydrogenase A expression." 11/01/2016 - "Complete response to nivolumab monotherapy in a treatment-naive, BRAF wild-type patient with advanced mucosal melanoma and elevated lactate dehydrogenase: a case report from a phase III trial."
4.	Glioma (Gliomas) 10/01/2020 - "In the present study, lactate dehydrogenase A (LDHA) is significantly increased within glioma tissue samples and cells, further confirming the oncogenic role of LDHA within glioma. " 05/06/2022 - "LDH-A KD and GNE-R-140 unexpectedly increased the aggressiveness of GL261 intracranial gliomas, but not CT2A and ALTS1C1 i.c. " 05/06/2022 - "Genetic and Drug Inhibition of LDH-A: Effects on Murine Gliomas." 05/06/2022 - "These results suggest that GL261 glioma cells (but not CT2A and ALTS1C1 cells) are pre-programmed to have the capacity for activating different metabolic pathways with higher TCA cycle activity, and that this capacity is enhanced by LDH-A depletion. " 09/01/2017 - "More importantly, we found that LDH-A was involved in the LINK-A-mediated proliferation and invasion of glioma cells. "
5.	Colorectal Neoplasms (Colorectal Cancer) 08/01/2021 - "LDH-A negatively regulates dMMR in colorectal cancer." 01/01/2023 - "α-Hydroxybutyrate (α-HB), a byproduct metabolite increased in diabetes and cancer, including colorectal cancer (CRC), triggers lactate dehydrogenase A (LDHA) nuclear translocation. " 01/01/2016 - "The main objective of this work was to evaluate a new therapeutic strategy against a colitis-related colorectal cancer in vivo and in vitro by targeting mTOR-signaling and lactate dehydrogenase A. " 01/01/2019 - "The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. " 08/14/2015 - "Lactate dehydrogenase A negatively regulated by miRNAs promotes aerobic glycolysis and is increased in colorectal cancer."

Related Drugs and Biologics

1.	Lactate Dehydrogenase 5
2.	Lactic Acid (Lactate)
3.	Glucose (Dextrose)
4.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
5.	Hexokinase
6.	Facilitative Glucose Transport Proteins (Glucose Transporter)
7.	Pyruvate Dehydrogenase Acetyl-Transferring Kinase
8.	Isoenzymes
9.	Messenger RNA (mRNA)
10.	Pyruvate Kinase

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Drug Therapy (Chemotherapy)
4.	Diskectomy (Discectomy)
5.	Physical Therapy Modalities (Physical Therapy Technique)