Circular RNA

RNA molecules in which the 3' and 5' ends are covalently joined to form a closed continuous loop. They are resistant to digestion by EXORIBONUCLEASES.

Also Known As:

RNA, Circular; Circular RNA, Closed; Intronic RNA, Circular; RNA, Circular Intronic; RNA, Closed Circular; RNAs, Circular; Circular Intronic RNA; Circular RNAs; Closed Circular RNA; ciRNA; circRNA; circRNAs

Networked: 8918 relevant articles (79 outcomes, 2081 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Circular RNA: 8918

Experts

1.	Zhang, Wei: 49 articles (11/2022 - 01/2018)
2.	Wang, Wei: 40 articles (01/2022 - 01/2017)
3.	Li, Wei: 37 articles (10/2022 - 03/2015)
4.	Zhang, Jing: 36 articles (10/2022 - 03/2017)
5.	Zhang, Lei: 36 articles (10/2022 - 04/2017)
6.	Li, Yan: 35 articles (12/2022 - 08/2015)
7.	Li, Jun: 35 articles (05/2022 - 01/2018)
8.	Wang, Yan: 34 articles (11/2022 - 01/2018)
9.	Zhang, Yu: 34 articles (01/2022 - 01/2017)
10.	Wang, Jing: 32 articles (08/2022 - 01/2018)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "Nevertheless, investigation of the role of circRNAs is providing valuable insights that are likely to contribute to improved management of a serious and highly aggressive cancer." 04/01/2021 - "In terms of prognostic value, oncogenic circRNAs had a negative influence on overall survival (OS: HR = 2.27, 95% CI: 1.93 - 2.69), and the high expression of tumor suppressor circRNAs was related to improved survival outcomes (OS: HR = 0.56, 95% Cl: 0.44 - 0.72). " 01/01/2019 - "Furthermore, we found that high expression of tumor-suppressor circRNAs was correlated with improved clinical characteristics (tumor size: OR=0.72; 95%Cl: 0.56-0.92; TNM stage: OR=0.77, 95%Cl: 0.68-0.88) and longer survival times (OS: HR=0.49; 95%Cl: 0.42-0.56). " 01/01/2019 - "In terms of the prognostic values, oncogenic circRNAs had a negative influence on overall survival (OS: HR = 3.39, 95%Cl: 2.59-4.19), and high expression of tumor-suppressor circRNAs was relevant to improved survival outcomes (OS: HR = 0.46, 95%Cl: 0.37-0.56). " 07/24/2023 - "It is crucial to explore the function of key circRNAs and elucidate the underlying mechanisms to establish an effective in vivo delivery system to better utilize circRNAs as cancer treatment strategies. "
2.	Ischemic Stroke 12/04/2020 - "Thus, the circRNA circUCK2 may serve as a potential target for novel treatment in patients with ischemic stroke." 01/01/2022 - "Thus, the circRNA circ_0000831 may work as a possible target for novel treatment in patients with ischemic stroke." 11/01/2021 - "Circular RNA 0025984 Ameliorates Ischemic Stroke Injury and Protects Astrocytes Through miR-143-3p/TET1/ORP150 Pathway." 10/28/2020 - "Erratum: Bai et al., "Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity"." 01/01/2018 - "To our knowledge, this is the first report describing the efficacy of circRNA injection in an ischemic stroke model. "
3.	Glioma (Gliomas) 01/01/2019 - "Based on the stability and high conservation of circRNAs, we believe that circRNAs may have molecular targets that are useful for the treatment of glioma. " 11/01/2023 - "In this study, based on the IDH1 molecular typing of gliomas, we identified a significant downregulation of circRNA (circIQGAP1) expression in IDH1 mutant gliomas by high-throughput sequencing. " 09/01/2023 - "In this study, the upregulation of circRNA_0084043 in glioma and the association between circRNA_0084043 and glioma grade were identified. " 01/01/2023 - "The aim of this study was to explore the functions circRNA_103239 in the biological behaviour changes of glioma cells. " 01/01/2023 - "In this study, we employ next-generation sequencing (NGS) to investigate altered circRNA expression in glioma tissues. "
4.	Reperfusion Injury 08/01/2022 - "GATA1 regulates the microRNA‑328‑3p/PIM1 axis via circular RNA ITGB1 to promote renal ischemia/reperfusion injury in HK‑2 cells." 01/01/2022 - "Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a." 10/01/2021 - "Circular RNA PVT1 silencing prevents ischemia-reperfusion injury in rat by targeting microRNA-125b and microRNA-200a." 01/01/2021 - "Circular RNA Microarray Analyses in Hepatic Ischemia-Reperfusion Injury With Ischemic Preconditioning Prevention." 01/01/2020 - "Identification of differentially expressed circRNAs in cardiac ischemic reperfusion injury."
5.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2023 - "Therefore, it is important to identify circRNAs that can be used effectively for the clinical diagnosis and treatment of colorectal cancer (CRC). " 11/29/2023 - "Our study suggests that circRNA_0001573 and circRNA_0001573/miR-382-5p/FZD3 regulatory networks might provide a potential diagnosis for colorectal cancer." 01/01/2023 - "In this study, colorectal cancer cells (SW620) were treated with 1 mg/mL HD-SB for 24 h, and high-throughput sequencing of circRNAs was performed. " 01/01/2022 - "Recent studies have shown that the malignant progression of colorectal cancer is inseparable from the abnormal expression of circRNAs. " 01/01/2022 - "This study sought to evaluate the role of circRNAs in the diagnosis and prognosis of colorectal cancer (CRC). "

Related Drugs and Biologics

1.	Circular RNA
2.	MicroRNAs (MicroRNA)
3.	Biomarkers (Surrogate Marker)
4.	RNA (Ribonucleic Acid)
5.	Messenger RNA (mRNA)
6.	Long Noncoding RNA
7.	Competitive Endogenous RNA
8.	Proteins (Proteins, Gene)
9.	Glucose (Dextrose)
10.	Lipopolysaccharides

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Radiotherapy
4.	Precision Medicine
5.	Transplantation