Globus Sensation

08/21/2013 - "Rikkunshito improved globus sensation in patients with PPI-refractory LPR, in part, because of stimulation of gastric emptying. "
08/21/2013 - "The 4-wk treatment with rikkunshito alone and with rikkunshito plus the PPI significantly decreased the globus sensation VAS scores. "
01/01/2016 - "Efficacy of proton pump inhibitor in combination with rikkunshito in patients complaining of globus pharyngeus."
01/01/2016 - "Globus pharyngeus (GP) is a common symptom of laryngopharyngeal reflux disease (LPRD), and proton pump inhibitor (PPI) and rikkunshito, a traditional Japanese medicine having prokinetic effect improve LPRD symptoms. "
08/21/2013 - "Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux."

11/01/2010 - "This study indicates the possible role of weakly acid extraesophageal reflux episodes in some patients with globus pharyngeus. "
05/01/2010 - "The aim of the present study was to determine whether acid perfusion into the distal esophagus causes a globus sensation and an increase in upper esophageal sphincter (UES) pressure. "
05/01/2010 - "Globus sensation and increased upper esophageal sphincter pressure with distal esophageal acid perfusion."
06/01/2006 - "We concluded that decreased esophageal clearance in elderly subjects affects the defense mechanism against acid exposure and may be a risk factor for the appearance of globus sensation. "
12/01/1995 - "The symptom index is a useful additional marker to determine the significance of acid reflux in the pathogenesis of globus pharyngeus."

02/01/2014 - "The purpose of our study was to compare the diagnostic and therapeutic efficacy of barium esophagram and neck CT in patients with isolated globus sensation, to determine which of these modalities should be preferred in the evaluation of this condition. "
10/01/2015 - "The Role of the Modified Barium Swallow Study and Esophagram in Patients with Globus Sensation."
01/01/2006 - "The objective of this study was to determine the value of barium swallow pharyngoesophagography in the investigation of patients with globus pharyngeus who had no known disease, no operation history in the head and neck region, and no thyroid pathology. "
12/01/2018 - "Authors' response to Commentary on "Role of barium swallow pharyngoesophagography in the management of globus pharyngeus"."
12/01/2018 - "Role of barium swallow pharyngoesophagography in the management of globus pharyngeus."

08/01/2020 - "To evaluate the patient-reported reflux symptom index (RSI) and the doctors-reported Reflux finding score (RFS) as potential predictors for proton pump inhibitor (PPI) response in patients with suspected lower pharyngeal reflux, presenting with globus pharyngeus as their primary complaint. "
08/01/2020 - "Reflux finding score and reflux symptom index as potential predictors for proton pump inhibitor response in globus pharyngeus patients: A prospective study."
06/01/2013 - "Few data describing short-term proton pump inhibitor (PPI) treatment in patients with globus sensation exist. "
06/01/2013 - "Transition zone defect associated with the response to proton pump inhibitor treatment in patients with globus sensation."
01/01/2014 - "Nowadays, empirical therapy with a high dose of a proton pump inhibitor (PPI) is considered to be indicated for patients with globus sensation, after excluding organic diseases such as pharyngeal cancer, Zenker's diverticulum, or thyroid enlargement. "

10/01/1993 - "Ten of the IPHGM patients complained of throat discomfort or globus sensation, and these symptoms were relieved by histamine H2-antagonists, suggesting that these symptoms could be caused by acid secretion from IPHGM. "

01/01/2014 - "If patients without any esophageal motility dysfunctions are nonresponsive to PPI therapy, either cognitive-behavioral therapy, anti-depressants, or gabapentin could be helpful, although further well-designed, randomized controlled large-scale studies will be necessary to determine the effectiveness of each treatment strategy on patients with globus sensation. "
08/01/2013 - "This study was performed to investigate the effectiveness of treatment of globus pharyngeus with proton pump inhibitors, gabapentin, or both. "
08/01/2013 - "Globus pharyngeus: effectiveness of treatment with proton pump inhibitors and gabapentin."
08/01/2013 - "The inclusion criteria included a chief (primary) complaint of globus pharyngeus; a trial of proton pump inhibitor therapy for at least 2 months and/or a trial of gabapentin for at least 2 weeks; and at least 1 follow-up visit. "

09/01/2016 - "Clinical trials of antidepressants for treatment of globus are generally rare, let alone for refractory globus pharyngeus. "
01/01/2018 - "We investigated the association between the SLC6A4 polymorphism and globus pharyngeus and its response to treatment with antidepressants. "
07/01/1986 - "Three patients with globus hystericus responded to antidepressant medication. "
07/01/1986 - "Globus hystericus syndrome responsive to antidepressants."
01/01/2018 - "Serotonin Transporter Gene (SLC6A4) Polymorphism May Be Associated with Chinese Globus Pharyngeus and Its Antidepressant Effects."

06/01/2006 - "Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial."
01/01/2013 - "We intended to follow up all patients between 2004 and 2011 (n = 49) who received argon plasma ablation of gastric inlet patches for globus sensation at our clinic. "

10/01/2008 - "Lansoprazole in globus pharyngeus: double-blind, randomized, placebo-controlled trial."
10/01/2008 - "To evaluate the effectiveness of once-daily lansoprazole in the typical globus pharyngeus patient, who presents with a normal head and neck examination and without other sinister otolaryngologic complaints. "
10/01/2008 - "The globus pharyngeus patient who presents with a normal head and neck examination and without sinister otolaryngologic complaints does not benefit from once-daily lansoprazole therapy."

01/01/2022 - "Two studies demonstrated that GABA analogues may be a useful adjunct in patients with globus pharyngeus in the context of likely laryngeal sensory neuropathy. "
01/01/2022 - "The benefit of GABA analogues for improving nonorganic voice disorders is also promising while the benefit for globus pharyngeus when possibly related to laryngeal sensory neuropathy is inconclusive. "

08/01/2008 - "Globus sensation was significantly improved after PPF but did not change after medical therapy or NF. "
08/01/2009 - "Ablation of gastric inlet patches appears to be an effective therapy for alleviation of associated globus sensations. "
09/01/2010 - "Sixteen subjects with persistent globus sensation unresponsive to therapy for reflux disease and with normal esophageal/laryngeal imaging studies were invited to participate in a 7-session clinical protocol. "
09/26/2023 - "Patients with globus sensation had the lowest percent improvement on average in response to this therapy, reporting only about 25%. "
01/01/2013 - "This retrospective study indicates that APC of gastric inlet patches for the treatment of globus sensation might be a sufficient therapy option. "

01/01/2003 - "1. 36 patients with typical globus pharyngeus symptoms were randomised to treatment with speech therapy (Study group) and reassurance by nurse practitioner (Control group). "
08/01/2011 - "Speech therapy in the treatment of globus pharyngeus: how we do it."
01/01/2003 - "Initial results suggest that patients with globus pharyngeus symptoms benefit from speech therapy."
01/01/2003 - "The use of speech therapy in the treatment of globus pharyngeus patients. "
10/01/2015 - "However, several factors cast doubt on the solitary psychic genesis of the chronic cough: i) occurrence immediately after a penetrant cold, ii) embedding in other complaints of laryngeal hyperreagibility (larynx irritable), such as persistent globus pharyngeus sensation, throat clearing and episodic dysphonia, iii) first occurrence on old life, iv) erupting from sleep as well, v) persistence despite remission of the major depression, and v) no sustaining benefit from specific psychotherapy and speech therapy. "

01/01/2014 - "Herein, we report a case of a patient diagnosed with gastroesophageal reflux disease and aperistalsis who underwent Nissen (total, 360°) fundoplication after lack of response to medical treatment and subsequently underwent pneumatic dilatation due to unrelieved postoperative dysphagia and globus sensation. "
12/01/2015 - "The GERD-related symptom scores of regurgitation, heartburn, cough, expectoration, globus sensation and hoarseness all significantly decreased (all P<0.01) after the anti-reflux laparoscopic fundoplication, with the corresponding symptom remission rates as (79.4±23.2)%, (82.0±21.5)%, (72.2±28.5)%, (62.6±28.9)%, (76.1±31.5)% and (70.8±39.3)% respectively. "

03/01/2012 - "The patients reported an improvement in symptoms of globus pharyngeus after treatment (p<0.001). "
05/01/2021 - "GETS-J, the Japanese version of Glasgow Edinburgh Throat Scales (GETS), consisted of three subscales of throat symptoms (globus sensation, pain/swelling of the throat, and dysphagia) and somatic distress due to the disease, Frequency Scale for the Symptoms of Gastro-esophageal reflux disease (FSSG), and Hospital Anxiety and Depression Scale (HADS) were used before and after treatments. "

01/01/2013 - "Therefore, endoscopic follow-up and retreatment might be necessary if globus sensation is not sufficiently eliminated."