Nuclear Receptor Interacting Protein 1

A nuclear protein, characterized by multiple LXXLL motifs, that modulates activation of gene transcription by STEROID RECEPTORS, and transcriptional repression by NUCLEAR HORMONE RECEPTORS. It positively regulates gene expression of CIRCADIAN CLOCK PROTEINS AND PEPTIDES, including ARNTL TRANSCRIPTION FACTORS and CRYPTOCHROMES.

Also Known As:

Networked: 21 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bonnet, Sandrine: 2 articles (09/2021 - 05/2014)
2.	Jalaguier, Stéphan: 2 articles (09/2021 - 05/2014)
3.	Lapierre, Marion: 2 articles (09/2021 - 05/2014)
4.	Roepman, Paul: 2 articles (09/2021 - 05/2014)
5.	Fukumoto, Satoshi: 1 article (07/2022)
6.	Han, Xu: 1 article (07/2022)
7.	Hirofuji, Yuta: 1 article (07/2022)
8.	Kato, Hiroki: 1 article (07/2022)
9.	Kato, Takahiro A: 1 article (07/2022)
10.	Masuda, Keiji: 1 article (07/2022)

Related Diseases

1.	Papillary Thyroid Cancer 10/25/2021 - "This study aims to clarify the roles of circRNA nuclear receptor-interacting protein 1 (NRIP1; circNRIP1) and the possible mechanisms in papillary thyroid carcinoma (PTC). " 01/01/2023 - "Circular RNA nuclear receptor interacting protein 1 (circNRIP1), a newly discovered circRNA, has been confirmed to be closely associated with cervical carcinoma (CC), colorectal cancer (CRC), esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), nasopharyngeal carcinoma (NPC), non-small cell lung cancer (NSCLC), osteosarcoma (OS), ovarian cancer (OC) and papillary thyroid carcinoma (PTC). "
2.	Endometrial Neoplasms (Endometrial Cancer) 09/01/2021 - "The aim of the study was to analyze the expression of nuclear receptor interacting protein 1 (NRIP1) and its partner ligand-dependent nuclear receptor co-repressor (LCOR) in endometrioid endometrial cancer and to investigate their association with estrogen receptor (ER), progesterone receptor (PR), Ki-67, clinicopathological parameters and patient survival. "
3.	Down Syndrome (Down's Syndrome) 02/01/1998 - "The association of the RIP140 protein with the superfamily of nuclear receptors may be of significance in studies of trisomy 21 (Down syndrome) and Alzheimers disease, since a modifier locus has been speculated to reside on 21q11."
4.	Cakut 01/01/2022 - "In a previous study, we identified a heterozygous truncating variant in nuclear receptor-interacting protein 1 (NRIP1) as CAKUT causing via dysregulation of retinoic acid signaling. "
5.	Neoplasms (Cancer) 01/01/2021 - "Circular nuclear receptor interacting protein 1 (circNRIP1) is implicated in tumor initiation and progression; however, the underlying mechanism of keloid progression is unclear. " 10/01/2020 - "Nuclear receptor-interacting protein 1 (NRIP1), also named NR140, has been observed differentially express in multiple cancers, but the expression levels and the prognostic role of NRIP1 in stomach adenocarcinoma (STAD) remain unclear. " 11/01/2023 - "Circular RNA nuclear receptor interacting protein 1 (circ_NRIP1), as a circular RNA, is abnormally expressed in many human tumors and exhibits diverse functions in cancer progression. " 07/01/2023 - "CircRNA nuclear receptor interacting protein 1 (circ_NRIP1), a form of circRNA, is abnormally expressed in certain human tumor types. "

Related Drugs and Biologics

1.	Circular RNA
2.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
3.	Co-Repressor Proteins
4.	Tretinoin (Retinoic Acid)
5.	Progesterone Receptors (Progesterone Receptor)
6.	Estrogen Receptors
7.	Ligands
8.	Messenger RNA (mRNA)
9.	Catenins
10.	Estrogen Receptor beta