Saccharated Ferric Oxide (Venofer)

A glucaric acid-iron conjugate that is used in the treatment of IRON-DEFICIENCY ANEMIA, including in patients with chronic kidney disease, when oral iron therapy is ineffective or impractical.

Also Known As:

Venofer; Ferric Oxide, Saccharated; Ferri-Saccharate; Ferric Saccharate; Hippiron; Iron Oxide (Saccharated); Iron Sucrose; Iron(III)-Hydroxide Sucrose Complex; Iron-Saccharate; Ferri Saccharate; Iron Saccharate; D-Glucaric acid, iron(2+) salt (1:1)

Networked: 401 relevant articles (74 outcomes, 107 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Macdougall, Iain C: 9 articles (01/2020 - 08/2005)
2.	Dahl, Naomi V: 7 articles (01/2020 - 01/2011)
3.	Strauss, William E: 7 articles (01/2020 - 04/2014)
4.	Li, Zhu: 7 articles (04/2019 - 04/2014)
5.	Auerbach, Michael: 6 articles (01/2022 - 01/2017)
6.	Muñoz, Manuel: 6 articles (01/2022 - 10/2004)
7.	Thomsen, Lars L: 6 articles (01/2022 - 01/2017)
8.	Breymann, Christian: 6 articles (01/2020 - 11/2002)
9.	Cao, Gabriel: 6 articles (01/2017 - 01/2009)
10.	Bhandari, Sunil: 5 articles (03/2021 - 01/2016)

Related Diseases

1.	Anemia 01/01/2005 - "Iron sucrose, given weekly as 200 mg IV push over 5 min is an effective and safe anemia treatment in this population." 03/07/2009 - "We evaluated the efficacy of intravenous iron sucrose (IVIS) administration for correction of anemia in these patient populations. " 01/01/1998 - "She was intravenously treated by saccharated ferric oxide and her anemia was improved, but her bone marrow still showed much gelatinous material." 02/01/2023 - "Role of Intravenous Iron Sucrose in Severe Anemia in Late Pregnancy: A Case Report From Rural Ballabgarh, Haryana." 02/01/2023 - "In the difficult terrain of Himachal Pradesh, this makes IV iron sucrose a better option for anemic pregnant women who do not have easy access to health facilities resulting in a large number of them reaching hospitals with moderate to severe anemia at a later gestation."
2.	Iron-Deficiency Anemia (Anemia, Iron Deficiency) 06/01/2012 - "Intravenous Iron sucrose is a safe and effective treatment for the rapid reversal of iron deficiency anemia, in obstetric and gynecological settings." 01/01/2021 - "FERWON-NEPHRO was a randomized, open-label, multicenter clinical trial evaluating the safety and efficacy of a single infusion of FDI 1,000 mg versus up to 5 doses of iron sucrose (IS) 200 mg (recommended cumulative dose, 1,000 mg) over 8 weeks in patients with NDD-CKD and iron deficiency anemia. " 04/01/2014 - "Two 750-mg infusions of FCM are a safe and effective alternative to multiple lower dose iron sucrose infusions in NDD-CKD patients with iron-deficiency anemia." 03/01/2007 - "There is no apparent difference in the safety and efficacy of iron sucrose between elder and younger adults in the treatment of iron-deficiency anemia in HDD patients with CKD." 02/01/2016 - "Intravenous iron sucrose for children with iron deficiency anemia: a single institution study."
3.	Chronic Renal Insufficiency 11/01/2003 - "The safety and efficacy of an accelerated iron sucrose dosing regimen in patients with chronic kidney disease." 12/01/2023 - "To evaluate the short-term effect of intravenous iron sucrose administration on endogenous EPO secretion in patients with chronic kidney disease (CKD). " 04/01/2011 - "Patients who received iron sucrose for chronic renal disease were excluded from analysis. " 04/15/2006 - "The safety of high-dose iron sucrose infusion in hospitalized patients with chronic kidney disease was studied. " 04/15/2006 - "Safety of high-dose iron sucrose infusion in hospitalized patients with chronic kidney disease."
4.	Iron Deficiencies 06/01/2015 - "The study included patients with iron deficiency anaemia scheduled for elective orthopaedic surgery and treated with intravenous iron sucrose alone or associated with rHuEPO. " 07/30/2009 - "This study showed a lack of superiority of iron sucrose at 11 weeks but found evidence that iron sucrose reduced RLS symptoms both in the acute phase (7 weeks) and during long-term follow up in patients with variable degree of iron deficiency. " 01/01/2023 - "We studied the significance of the intravenous iron sucrose used to treat iron deficiency and the impact it may have on blood pressure during dialysis. " 01/01/2023 - "Many factors can contribute to intra-HD blood pressure (BP) changes, such as drugs with vasoactive properties that can destabilize an already tenuous BP. Intravenous iron sucrose is commonly administered to correct iron deficiency; however, its reported associations with altered hemodynamics have not been consistent. " 01/01/2020 - "Iron Sucrose: A Wealth of Experience in Treating Iron Deficiency."
5.	Inflammation (Inflammations) 02/01/2012 - "Comparison of oxidative stress and inflammation induced by different intravenous iron sucrose similar preparations in a rat model." 07/01/2011 - "In this study, we developed four experimental iron overload models in young rats using iron sucrose and evaluated different markers of iron overload, tissue oxidative stress and inflammation as its consequences. " 06/01/2016 - "Anemia-induced inflammation was prevented by iron sucrose as indicated by the levels of proinflammatory (TNF-α, NF-κB65) and repair process markers (HSP27, HSP70). " 05/01/2004 - "Anaemia associated with IBD can be successfully treated with intravenously administered iron sucrose, provided that bowel inflammation is treated adequately and enough iron is given. " 06/01/2020 - "Iron induced intraperitoneal inflammation observed in our previous studies with iron sucrose may deteriorate the function of the peritoneum as the dialysis membrane. "

Related Drugs and Biologics

1.	Iron
2.	Dextrans (Dextran)
3.	Hemoglobins (Hemoglobin)
4.	ferric carboxymaltose
5.	Erythropoietin
6.	Ferrosoferric Oxide (Magnetite)
7.	Saccharated Ferric Oxide (Venofer)
8.	iron isomaltoside 1000
9.	ferrous sulfate
10.	ferric derisomaltose

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Blood Transfusion (Blood Transfusions)
4.	Parenteral Nutrition
5.	Orthopedic Procedures