Alitretinoin

A retinoid that is used for the treatment of chronic hand ECZEMA unresponsive to topical CORTICOSTEROIDS. It is also used to treat cutaneous lesions associated with AIDS-related KAPOSI SARCOMA.

Also Known As:

Networked: 340 relevant articles (44 outcomes, 67 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ruzicka, T: 10 articles (04/2015 - 04/2008)
2.	Molin, S: 7 articles (01/2016 - 09/2008)
3.	Maares, J: 7 articles (10/2012 - 04/2008)
4.	Ruzicka, Thomas: 4 articles (11/2020 - 12/2004)
5.	Roos, B: 4 articles (07/2012 - 04/2011)
6.	Schmitt-Hoffmann, A H: 4 articles (07/2012 - 04/2011)
7.	Grubbs, Clinton J: 4 articles (06/2006 - 05/2002)
8.	Lubet, Ronald A: 4 articles (06/2006 - 09/2002)
9.	Steele, Vernon E: 4 articles (02/2004 - 05/2002)
10.	Napolitano, Maddalena: 3 articles (02/2022 - 01/2021)

Related Diseases

1.	Eczema 05/01/2020 - "Systemic alitretinoin, a pan-retinoic receptor agonist, has proven efficacy in the treatment of recalcitrant chronic hand eczema; however, its precise mechanism of action in hand eczema is not fully understood. " 09/01/2016 - "In clinical trials, treatment with alitretinoin 10 or 30 mg once daily for up to 24 weeks improved the severity and extent of severe chronic hand eczema in adults, with significantly more alitretinoin than placebo recipients achieving ratings of 'clear' or 'almost clear' hands on the Physician Global Impression of Change scale. " 03/01/2011 - "Blinded, controlled studies have found that oral alitretinoin is well tolerated and effective in the treatment of severe chronic hand eczema (CHE). " 02/01/2021 - "Oral alitretinoin is effective in the treatment of chronic hand eczema (CHE), and ≥12 weeks of alitretinoin treatment has been shown to be effective in Korean patients. " 10/01/2009 - "Alitretinoin has been shown to be effective in a randomized controlled trial, and is currently the only treatment specifically licensed for the treatment of hand eczema. "
2.	Neoplasms (Cancer) 10/01/2001 - "A phase I trial and pharmacokinetic study of 9-cis-retinoic acid (ALRT1057) in pediatric patients with refractory cancer: a joint Pediatric Oncology Branch, National Cancer Institute, and Children's Cancer Group study." 06/01/1998 - "Phase I study of 9-cis-retinoic acid (ALRT1057 capsules) in adults with advanced cancer." 09/15/2002 - "9-cis-retinoic acid but not 4-(hydroxyphenyl)retinamide inhibits prostate intraepithelial neoplasia in Noble rats." 06/01/1998 - "KS, which is not a true cancer, seems to respond to chemotherapy, and study results to determine the safety and efficacy of panretin, atragen, and IM-862 on KS lesions are highlighted. " 01/01/1994 - "Comparing all-trans- with 9-cis-retinoic acid, the latter was more effective in inhibiting tumor cell growth and in inducing synergism with interferon-gamma. "
3.	Breast Neoplasms (Breast Cancer) 07/01/2018 - "Taken together, our study showed the potential inhibitory role for 9-cis-retinoic acid in breast cancer progression by attenuating cell invasion and migration." 07/01/2018 - "Metabolomics research on potential role for 9-cis-retinoic acid in breast cancer progression." 08/01/1995 - "Effect of 9-cis-retinoic acid on growth and RXR expression in human breast cancer cells." 05/15/1995 - "Synergistic inhibition of cell proliferation under treatment with 9-cis-retinoic acid and IFN-gamma was detected in the three breast cancer cell lines MCF-7, SKBR-3, and even in the RA-resistant BT-20 cells. " 02/01/2004 - "The present studies were performed to evaluate the efficacy of 9-cis-retinoic acid (9-cis-RA) and N-(4-hydroxyphenyl) retinamide (4-HPR), alone and combined, in preventing mammary cancers. "
4.	Dermatitis 07/01/2012 - "Moderate to severe chronic hand dermatitis (CHD) is not well controlled by current medical strategies; however, recent studies have shown significant improvement in patients treated with up to 6 months of oral alitretinoin (9-cis-retinoic acid). " 07/01/2012 - "Effective treatment of chronic hand dermatitis with 36 continuous months of alitretinoin administration: report of three cases." 03/01/2008 - "Orally administered alitretinoin is a safe and effective treatment for chronic hand dermatitis. " 01/01/2018 - "Herein, real-world evidence supporting the safety and effectiveness of alitretinoin in the management of chronic hand dermatitis will be reviewed." 01/01/2018 - "Alitretinoin: An Update of Real-World Evidence in The Management of Chronic Hand Dermatitis."
5.	Kaposi Sarcoma (Kaposi's Sarcoma) 01/01/2003 - "Two other trials involving 402 people demonstrated that topical alitretinoin was effective treatment compared to placebo among patients with cutaneous Kaposi's sarcoma. " 01/01/2007 - "We report a case of Kaposi's sarcoma treated with topical alitretinoin that had a favourable evolution in spite of an intense local reaction." 01/01/2007 - "[Kaposi's sarcoma treated with topical alitretinoin]." 10/01/2006 - "Failure of topical 0.1% alitretinoin gel for classic Kaposi sarcoma: first European experience." 04/01/2002 - "Topical 0.1% alitretinoin gel for classic Kaposi sarcoma."

Related Drugs and Biologics

1.	Retinoids
2.	Alitretinoin
3.	Adrenal Cortex Hormones (Corticosteroids)
4.	Acitretin
5.	Isotretinoin (Accutane)
6.	Tretinoin (Retinoic Acid)
7.	Cyclosporine (Ciclosporin)
8.	PPAR gamma
9.	Steroids
10.	Interferon-alpha (Interferon Alfa)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Photochemotherapy (Photodynamic Therapy)
4.	Palliative Care (Palliative Therapy)
5.	Chemoprevention