Craniofacial Fibrous Dysplasia

Mostly benign fibro-osseous proliferation of the facial bones and skull. It can be either monostotic (localized to a single bone) or polyostotic (localized to more than one bone) type.

Also Known As:

Craniomaxillofacial Fibrous Dysplasia; Fibrous Dysplasia of Skull; Fibrous Dysplasia, Craniofacial; Maxillary Fibrous Dysplasia; Craniofacial Fibrous Dysplasias; Craniomaxillofacial Fibrous Dysplasias; Dysplasia, Maxillary Fibrous; Fibrous Dysplasia, Craniomaxillofacial; Fibrous Dysplasia, Maxillary; Maxillary Fibrous Dysplasias; Skull Fibrous Dysplasia; Skull Fibrous Dysplasias

Networked: 37 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Bone Diseases: 5863
  - Developmental Bone Diseases: 153
    - Osteochondrodysplasias: 592
      - Fibrous Dysplasia of Bone: 78
        Craniofacial Fibrous Dysplasia: 37

Related Diseases

1.	Neoplasms (Cancer)
2.	Polyostotic Fibrous Dysplasia (McCune Albright Syndrome)
3.	Vision Disorders (Hemeralopia)
4.	Pituitary Neoplasms (Pituitary Adenoma)
5.	Papilledema

Experts

1.	Chen, Ying: 2 articles (03/2015 - 09/2014)
2.	Gui, Lai: 2 articles (03/2015 - 09/2014)
3.	Wang, Meng: 2 articles (03/2015 - 09/2014)
4.	Gao, Y: 1 article (01/2022)
5.	Lin, L: 1 article (01/2022)
6.	Liu, K: 1 article (01/2022)
7.	Wang, X: 1 article (01/2022)
8.	Xie, L: 1 article (01/2022)
9.	Boyce, Alison M: 1 article (12/2021)
10.	Collins, Michael T: 1 article (12/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Craniofacial Fibrous Dysplasia:

1.	Alkaline PhosphataseIBA 10/01/2013 - "A retrospective study on craniofacial fibrous dysplasia: preoperative serum alkaline phosphatase as a prognostic marker?" 03/01/2010 - "Prognosis for craniofacial fibrous dysplasia after incomplete resection: age and serum alkaline phosphatase." 03/01/2017 - "The purpose of this study was to determine the usefulness of serum alkaline phosphatase (ALP) and calcitonin in the follow-up of tumor volume changes in patients with craniofacial fibrous dysplasia. " 03/01/2017 - "Craniofacial Fibrous Dysplasia: Retrospective Study on the Relationship Between the Tumor Volume Changes and the Circulating Serum Calcitonin and Serum Alkaline Phosphatase."
2.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 03/01/2017 - "The purpose of this study was to determine the usefulness of serum alkaline phosphatase (ALP) and calcitonin in the follow-up of tumor volume changes in patients with craniofacial fibrous dysplasia. " 03/01/2017 - "Craniofacial Fibrous Dysplasia: Retrospective Study on the Relationship Between the Tumor Volume Changes and the Circulating Serum Calcitonin and Serum Alkaline Phosphatase."
3.	SolutionsIBA 12/01/2020 - "Four patients were rated category I on the Whitaker rating scale, and one patient as category II. In conclusion, this patient-specific surgical depth guide appears to offer a solution for the unpredictability of conventional bone removal in unilateral craniofacial fibrous dysplasia, especially in three-dimensional multiplanar areas such as the zygoma. " 07/01/2009 - "[Solution to case 6. Maxillary fibrous dysplasia]."
4.	Radioisotopes (Radionuclides)IBA 07/01/1977 - "Craniofacial fibrous dysplasia (CFD) may show arterial displacement or increased uptake during arterial, capillary, venous, and blood-pool phases of radionuclide angiography. " 07/01/1977 - "Radionuclide angiography--brain and bone imaging in craniofacial fibrous dysplasia (CFD): case report." 03/01/1989 - "Craniofacial fibrous dysplasia complicated by mucocele: the role of radionuclide scintigraphic methods in the diagnosis."
5.	Denosumab FDA Link 09/01/2021 - "Denosumab for craniofacial fibrous dysplasia: duration of efficacy and post-treatment effects." 09/01/2016 - "Prompt clinical and biochemical response to denosumab in a young adult patient with craniofacial fibrous dysplasia."
6.	Parathyroid Hormone-Related ProteinIBA 04/20/2023 - "PTHrP Modulates the Proliferation and Osteogenic Differentiation of Craniofacial Fibrous Dysplasia-Derived BMSCs."
7.	Bone SubstitutesIBA 10/11/2023 - "Alveolar Bone Box Ostectomy Grafted with Particulate Bone Substitute with Subsequent Dental Implant Placement in a Case of Craniofacial Fibrous Dysplasia Involving the Posterior Maxilla: Case Report and Literature Review."
8.	Dental Implants (Dental Implant)IBA 10/11/2023 - "This case report describes a novel approach for dental-implant-based rehabilitation of the posterior maxilla affected by craniofacial fibrous dysplasia (CFD), with 7 years of treatment follow-up. " 10/11/2023 - "Alveolar Bone Box Ostectomy Grafted with Particulate Bone Substitute with Subsequent Dental Implant Placement in a Case of Craniofacial Fibrous Dysplasia Involving the Posterior Maxilla: Case Report and Literature Review."
9.	TitaniumIBA 01/01/2014 - "The recurrence and regrowth of craniofacial fibrous dysplasia (FD) along the repaired titanium mesh (TM) after total removal are extremely rare. " 01/01/2014 - "Recurring craniofacial fibrous dysplasia with extensive titanium mesh invasion."
10.	Growth Hormone (Somatotropin)IBA 09/01/2014 - "Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome."

Therapies and Procedures

1.	Conservative Treatment 01/01/2023 - "This study aimed to propose a novel surgical technique, named multiple tangential shaving of bone contour, for the conservative management of craniofacial fibrous dysplasia. " 01/01/2023 - "In conclusion, the multiple tangential shaving technique allows an easy approach for conservative management of craniofacial fibrous dysplasia. " 01/01/2023 - "We retrospectively reviewed 17 patients who underwent conservative management of craniofacial fibrous dysplasia using multiple tangential shaving technique between July 2005 and December 2020. " 01/01/2023 - "A Novel Bone Contouring Technique Using Multiple Tangential Shaving for Conservative Management of Craniofacial Fibrous Dysplasia." 05/01/2014 - "Conservative treatment and implant rehabilitation of the mandible in a case of craniofacial fibrous dysplasia: a case report."
2.	Smart Glasses 01/01/2022 - "The aim of this study was to apply an augmented reality (AR) navigation technique based on a head- mounted display in the treatment of craniofacial fibrous dysplasia and to explore the feasibility and the value of AR in craniofacial surgery. "
3.	Decompression 12/01/2007 - "Optic nerve compression in craniofacial fibrous dysplasia: the role and indications for decompression." 02/01/1996 - "Early optic nerve decompression is highly recommended to preserve visual function in patients with craniofacial fibrous dysplasia causing visual disturbance." 03/01/2009 - "Correction of proptosis and zygomaticomaxillary asymmetry using orbital wall decompression and zygoma reduction in craniofacial fibrous dysplasia." 01/01/2023 - "To investigate the feasibility of endoscopic transnasal optic canal decompression (ETOCD) guided by a navigation surgical system (NSS) for vision recovery in patients with compressive optic neuropathy (CON) caused by craniofacial fibrous dysplasia (CFD), and to explore the underlying cause of visual impairment. "
4.	Orthognathic Surgery 03/01/1999 - "Orthognathic surgery in craniomaxillofacial fibrous dysplasia." 07/01/2010 - "We report a case of polyostotic craniofacial fibrous dysplasia in which two-jaw orthognathic surgery was performed using a navigation system with the Le Fort 1 osteotomy procedure. "
5.	Computer-Assisted Surgery (Image Guided Surgery) 09/01/2005 - "[Computer-assisted surgery (CAS) for the optimal treatment of craniofacial fibrous dysplasia]." 01/01/2023 - "To investigate the feasibility of endoscopic transnasal optic canal decompression (ETOCD) guided by a navigation surgical system (NSS) for vision recovery in patients with compressive optic neuropathy (CON) caused by craniofacial fibrous dysplasia (CFD), and to explore the underlying cause of visual impairment. "