Resveratrol

A stilbene and non-flavonoid polyphenol produced by various plants including grapes and blueberries. It has anti-oxidant, anti-inflammatory, cardioprotective, anti-mutagenic, and anti-carcinogenic properties. It also inhibits platelet aggregation and the activity of several DNA HELICASES in vitro.

Also Known As:

3,4',5-Stilbenetriol; 3,4',5-Trihydroxystilbene; 3,5,4'-Trihydroxystilbene; Resveratrol, (Z)-; Resveratrol-3-sulfate; SRT 501; SRT-501; SRT501; cis-Resveratrol; trans-Resveratrol; trans-Resveratrol-3-O-sulfate; Resveratrol 3 sulfate; cis Resveratrol; trans Resveratrol; trans Resveratrol 3 O sulfate; 1,3-Benzenediol, 5-((E)-2-(4-hydroxyphenyl)ethenyl)-

Networked: 7464 relevant articles (1016 outcomes, 2082 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Polyphenols: 7483
        Resveratrol: 7464
        Benzylidene Compounds: 10
        Stilbenes: 657
        Stilbestrols: 1
        Resveratrol: 7464

Experts

1.	Liu, Jia: 37 articles (08/2022 - 11/2003)
2.	Li, Hong: 35 articles (08/2022 - 11/2003)
3.	Delmas, Dominique: 34 articles (10/2021 - 12/2002)
4.	Das, Dipak K: 32 articles (01/2012 - 05/2002)
5.	Latruffe, Norbert: 31 articles (06/2021 - 08/2002)
6.	Lin, Hung-Yun: 30 articles (01/2021 - 03/2002)
7.	Dyck, Jason R B: 26 articles (01/2021 - 08/2008)
8.	Davis, Paul J: 25 articles (04/2020 - 03/2002)
9.	Wu, Joseph M: 25 articles (03/2020 - 01/2002)
10.	Wu, Mo-Li: 24 articles (08/2022 - 08/2005)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2016 - "Among the phenolics tested, resveratrol was the most effective in inhibiting growth of cancer cells. " 12/01/2014 - "In a therapeutic assay where tumors were allowed to develop prior to treatment, feeding tumor bearing mice with resveratrol resulted in a complete remission in 33% of the mice and a 97% decrease in tumor size in the remaining mice. " 10/30/2021 - "We found that resveratrol shows efficacy for the treatment of cancer, but due to high controversy on the Nrf2 signaling pathway and mechanisms of resveratrol action, additional studies should be conducted to better characterize its mode-of-action in cancer." 06/01/2015 - "Resveratrol has emerged in recent years as a compound conferring strong protection against metabolic, cardiovascular and other age-related complications, including neurodegeneration and cancer. " 08/01/2009 - "In addition, the size of tumors in C3H/HeN mice was reduced in vivo and their survival in vitro was inhibited by resveratrol to a significantly greater extent than in C3H/HeJ mice. "
2.	Inflammation (Inflammations) 02/01/2013 - "Resveratrol is a phytoalexin synthesized by a wide variety of plants, which has been proven to be effective in suppressing oxidative stress and inflammation. " 10/02/2022 - "Treatment with resveratrol can significantly normalize OGD-induced changes in SH-SY5Y cell inflammation, oxidative stress, and oxidative defense gene expression; however, these resveratrol protective effects are affected by AMPK antagonists (Compounds C) blocking. " 01/01/2019 - "Our findings suggest that resveratrol exerts anti-inflammatory effects via post-translational regulation of IL-1β production and, thus, may prove beneficial for the treatment of MSU crystal-mediated sterile inflammation. " 03/01/2014 - "Exercise training is more effective than resveratrol supplementation on alleviation of inflammation in peritoneal macrophages of high fat diet mice." 01/01/2021 - "The Emulgel containing 2% resveratrol is effective in improving gingival health in orthodontic patients and can lower gingival inflammation over 8 weeks. "
3.	Insulin Resistance 11/01/2011 - "Our studies show that marked improvement in insulin sensitivity can be elicited by acute administration of resveratrol to the MBH or during acute systemic administration. " 01/01/2013 - "Although resveratrol had positive effects on adiposity and cyclicity in a similar manner to exercise, resveratrol does not seem to be a good candidate for treating insulin resistance associated with PCOS because no improvement in insulin sensitivity was observed in PCOS rats on normal chow." 02/01/2020 - "Resveratrol ameliorates metabolic disorders and insulin resistance in high-fat diet-fed mice." 07/01/2018 - "In addition, insulin resistance was improved after an 8-week treatment with resveratrol. " 03/01/2018 - "Results indicated that the induction of PCOS in rats increased lipid peroxidation and insulin resistance and resveratrol improved these complications."
4.	Cardiovascular Diseases (Cardiovascular Disease) 09/01/2012 - "Although calorie restriction and resveratrol have proven to be very effective in preventing and treating the development of cardiovascular disease in animal models, studies continue as to whether these profound beneficial effects can translate to humans to improve cardiovascular health." 08/01/2015 - "In the past two decades, many preclinical and a few pilot clinical studies have shown that resveratrol is beneficial in protecting against cardiovascular disease. " 01/01/2014 - "However, the effect of resveratrol on PON1 gene expression and activity was significant, suggesting increase in PON1 activity and enhanced gene expression may be its alternative mechanism for offering protection against cardiovascular disease and may be an potential pharmacological agent which can be used for this. " 12/01/2009 - "Resveratrol, a polyphenolic constituent of red wine, is known for its anti-atherogenic properties and is thought to be beneficial in reducing the incidence of cardiovascular diseases (CVD). " 06/01/2007 - "Resveratrol: a therapeutic promise for cardiovascular diseases."
5.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Kaplan-Meier plotter analysis found that resveratrol-induced expression changes in key RNAs, such as E2F2, JUN, FOS, BRCA1, CDK1, CDKN1A, TNF, and hsa-miR-34a-5p, significantly improved the prognosis of breast cancer patients, which was further verified using real-time quantitative PCR (qPCR) and western blotting. " 07/01/2013 - "For example, significantly greater sulfation of resveratrol occurs in human breast tumor tissue than in adjacent nonmalignant tissue. " 08/01/2022 - "Higher efficacy of resveratrol against advanced breast cancer organoids: A comparison with that of clinically relevant drugs." 11/02/2023 - "The study highlights the therapeutic potential of the synthesized resveratrol derivative, RsvD1, positioning it as a promising scaffold for developing novel analogues with improved therapeutic properties and selectivity, specifically targeting ER+ breast cancer cells. " 10/15/2022 - "Our results provide evidence supporting the targeted delivery of resveratrol to mitochondria and suggest that TPP-resveratrol may be an effective agent for breast cancer treatment."

Related Drugs and Biologics

1.	Antioxidants
2.	Sirtuin 1
3.	Polyphenols
4.	Curcumin
5.	Quercetin
6.	Glucose (Dextrose)
7.	Phytochemicals
8.	epigallocatechin gallate (epigallocatechin-3-gallate)
9.	Lipids
10.	Insulin (Novolin)

Related Therapies and Procedures

1.	Therapeutics
2.	Chemoprevention
3.	Drug Therapy (Chemotherapy)
4.	Caloric Restriction
5.	Glycemic Control