Tuberous Sclerosis Complex 1 Protein
An intracellular signaling and tumor suppressor protein that forms a complex with TUBEROUS SCLEROSIS COMPLEX 2 PROTEIN (TSC2) and other signaling factors to negatively regulate MTORC1 signaling and affect cell growth and proliferation. Structurally, it interacts with TSC2 through its N-terminal, which also contains GSK-3BETA phosphorylation sites and a RHO-KINASE activation domain. It also contains a C-terminal coiled-coil domain and ezrin-radixin-moesin (ERM) domain. Mutations in the TSC1 gene are associated with TUBEROUS SCLEROSIS.
Networked: 158
relevant articles (5 outcomes,
9 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Blenis, John:
6 articles
(02/2022 - 10/2002)
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2. | Kotulska, Katarzyna:
6 articles
(01/2018 - 02/2004)
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3. | Tee, Andrew R:
5 articles
(02/2022 - 10/2002)
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4. | Kwiatkowski, David J:
5 articles
(01/2021 - 10/2002)
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5. | Hengstschläger, Markus:
5 articles
(07/2009 - 12/2003)
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6. | Rosner, Margit:
5 articles
(07/2009 - 12/2003)
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7. | Cantley, Lewis C:
4 articles
(02/2022 - 10/2002)
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8. | Manning, Brendan D:
4 articles
(02/2022 - 10/2002)
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9. | Prabhakar, Shilpa:
4 articles
(01/2021 - 12/2005)
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10. | Ramesh, Vijaya:
4 articles
(01/2021 - 11/2002)
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