Histone Methyltransferases

Enzymes that catalyze the transfer of methyl groups to LYSINE or ARGININE residues of HISTONES, especially histone H3 and histone H4 proteins. They play a critical role in EPIGENETIC PROCESSES.

Also Known As:

Histone H3 Methyltransferase; Histone Methylase; Histone Methyltransferase; Histone-Arginine N-Methyltransferase; H3 Methyltransferase, Histone; Histone Arginine N Methyltransferase; Methylase, Histone; Methyltransferase, Histone; Methyltransferase, Histone H3; Methyltransferases, Histone; N-Methyltransferase, Histone-Arginine

Networked: 1204 relevant articles (16 outcomes, 86 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        Protein Methyltransferases: 69
        Histone Methyltransferases: 1204
        Histone-Lysine N-Methyltransferase: 196
        C elegans set-32 protein
        human PRDM8 protein
        human SETD3 protein
        mouse PRDM8 protein
        mouse Setd3 protein
        Xenopus laevis Ash2l.L protein
        zebrafish Smyd4 protein

Experts

1.	Hamamoto, Ryuji: 19 articles (11/2021 - 08/2004)
2.	Nakamura, Yusuke: 11 articles (10/2015 - 08/2004)
3.	Wang, Lei: 9 articles (10/2022 - 08/2016)
4.	Licht, Jonathan D: 9 articles (01/2022 - 02/2010)
5.	van Bokhoven, Hans: 9 articles (10/2019 - 03/2010)
6.	Cho, Hyun-Soo: 8 articles (09/2022 - 07/2011)
7.	Kleefstra, Tjitske: 8 articles (01/2021 - 03/2013)
8.	Shinkai, Yoichi: 8 articles (01/2021 - 04/2003)
9.	Luo, Xue-Gang: 8 articles (05/2020 - 05/2007)
10.	Toyokawa, Gouji: 8 articles (01/2019 - 07/2011)

Related Diseases

1.	Neoplasms (Cancer) 11/04/2008 - "In this issue of Cancer Cell, Krivtsov et al. report a much-improved murine Mll-AF4 model and propose a molecular link with H3K79 methylation mediated by the histone methyltransferase DOT1L." 01/01/2023 - "This study found that the histone methyltransferase DOT1 L regulates the self-renewal and tumor initiation capacity of ovarian CSCs and suggests DOT1 L as a new cancer target." 01/01/2019 - "In this study, we report that two lncRNAs frequently downregulated in HCC function as tumor suppressors and are epigenetically silenced by histone methyltransferase EZH2. " 03/01/2016 - "Functional studies investigating histone methyltransferase activity of mutant EZH2 from various cancers have been reported, whereas WS-associated mutations remain poorly characterized. " 12/01/2009 - "To study the role of miR-155 in these tumors, we identified JARID2/Jumonji, a cell cycle regulator and part of a histone methyltransferase complex, as a target of miR-155. "
2.	Leukemia 10/01/2023 - "The aim of our study was to explore function of histone methyltransferase KMT2D (MLL4, mixed-lineage leukemia 4) in angiogenesis post-MI. " 01/01/2020 - "This study aimed to explore the underlying mechanism of neuron apoptosis in ischemic penumbra via histone methyltransferase (HMT) mixed lineage leukemia 1 (MLL1) mediated epigenetic pathway. " 08/08/2013 - "Genetic and small molecule inhibitor studies have demonstrated that the histone methyltransferase DOT1L is required for the development and maintenance of MLL-rearranged leukemia in model systems. " 12/01/2023 - "Mutations in the histone methyltransferase Ezh2 drive context-dependent leukemia in Xenopus tropicalis." 11/01/2022 - "Here, we found that the phosphorylated histone methyltransferase mixed lineage leukemia 1 (MLL1) was maintained at UV-irradiated sites in an HBO1-dependent manner. "
3.	Melanoma (Melanoma, Malignant) 01/01/2021 - "We demonstrate that G9a histone methyltransferase inhibition is able to not only robustly induce LC3B level to augment the efficacy of checkpoint inhibitor blockade, but also induces melanoma cell death. " 09/25/2020 - "Recent studies, including the research previously conducted in our laboratory, reported that the histone methyltransferase SETDB1 contributes to melanoma pathogenesis. " 12/01/2019 - "Although functional analysis of this rare co-segregating variant did not reveal compromised histone methyltransferase activity and ultraviolet exposure sensitivity, the role of DOT1L as melanoma susceptibility gene deserves further study." 05/01/2014 - "This study investigated the potential association of p16(INK) (4A) promoter methylation with histone methyltransferase SETDB1 expression in Greek patients with sporadic melanoma and their correlation with clinicopathological characteristics. " 01/01/2020 - "We found conserved expression changes in histone methyltransferase genes ASH2, EZH2, PRMT5, SUV39H1, SUV39H2, and SYMD2 in P-ERK low, p-38 high melanoma cells following prolonged BRAF inhibition. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "Thus, in this study, EHMT2 (a histone methyltransferase) was determined to be significantly overexpressed in breast cancer tissues and in Oncomine data. " 07/01/2014 - "This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, RORγ, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. " 12/01/2022 - "Here we show that inhibition of the H3K4 histone methyltransferase MLL1 in combination with PI3K inhibition impairs HR+ breast cancer clonogenicity and cell proliferation. " 01/01/2022 - "Mechanistically, inhibition of EZH2 histone methyltransferase alone by EZH2 inhibitors in breast cancer cells could reduce the enrichment of H3K27me3 on CCL2 gene promoter, elevate CCL2 transcription and secretion, contributing to the induction of M2 macrophage polarization and recruitment in TME, which reveal a potential explanation behind the frustrating results of EZH2 inhibitors against breast cancer. " 10/01/2020 - "Impact of histone methyltransferase SUV420H2 in breast cancer."
5.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/01/2023 - "Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells." 11/29/2022 - "Histone methyltransferase SETD1A is critical for acute myeloid leukemia (AML) cell survival, but the molecular mechanism driving SETD1A gene regulation remains elusive. " 11/01/2021 - "Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia." 01/01/2017 - "Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia." 05/01/2011 - "Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2."

Related Drugs and Biologics

1.	3-deazaneplanocin
2.	DNA (Deoxyribonucleic Acid)
3.	Histones (Histone)
4.	Lysine (L-Lysine)
5.	Histone Acetyltransferases (Histone Acetyltransferase)
6.	Histone Deacetylase Inhibitors
7.	Tamoxifen
8.	trichostatin A (A 300)
9.	Therapeutic Uses
10.	Poly(ADP-ribose) Polymerase Inhibitors

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Therapeutics
3.	Immunotherapy
4.	Castration
5.	Precision Medicine