CCCTC-Binding Factor

A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

Also Known As:

Networked: 95 relevant articles (1 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Qin, Yang: 3 articles (06/2022 - 04/2010)
2.	Poon, Gregory M K: 2 articles (10/2021 - 01/2021)
3.	Stark, Bastian: 2 articles (10/2021 - 01/2021)
4.	Wyrick, John J: 2 articles (10/2021 - 01/2021)
5.	Arens, Christoph: 2 articles (01/2021 - 01/2018)
6.	Lichtenstern, Christoph: 2 articles (01/2021 - 01/2018)
7.	Siegler, Benedikt Hermann: 2 articles (01/2021 - 01/2018)
8.	Uhle, Florian: 2 articles (01/2021 - 01/2018)
9.	Weigand, Markus Alexander: 2 articles (01/2021 - 01/2018)
10.	Weiterer, Sebastian: 2 articles (01/2021 - 01/2018)

Related Diseases

1.	Non-alcoholic Fatty Liver Disease 01/01/2021 - "Regulatory roles of both CCCTC-binding factor (CTCF) and dipeptidyl peptidase-4 (DPP4) have been reported in NAFLD, but it is still unclear whether the mechanism of action of gardenoside, a potential therapeutic for NAFLD, can be driven via these proteins. "
2.	Prostatic Neoplasms (Prostate Cancer) 11/06/2018 - "A recent study used CRISPR/Cas9 to reveal long-range looping between disease-related genes and their regulatory elements that is mediated by the CCCTC-binding factor (CTCF) in prostate cancer." 01/01/2020 - "Expression of CCCTC-binding factor (CTCF) is linked to poor prognosis in prostate cancer." 01/01/2019 - "The present research focuses on the influence of CCCTC-binding factor (CTCF) on prostate cancer (PC) via the regulation of the FoxO signalling pathway. " 01/01/2023 - "In this study, we find that MYC rewires prostate cancer chromatin architecture by interacting with CTCF protein. " 01/01/2009 - "Potential novel tumour suppressor genes (TSG) at 16q include CCCTC-binding factor (CTCF), Decreased Expression in Renal and Prostate Cancer (DERPC) and Dipeptidase 1 (DPEP1). "
3.	Breast Neoplasms (Breast Cancer) 05/01/2022 - "Here, we report a kind of targeted core-shell nanoparticles (NPs) carrying dual plasmids (pHR-pCas9) for precise CCCTC-binding factor (CTCF) gene insert to circumvent metastatic breast cancer. " 01/01/2004 - "A screen for germline mutations in the gene encoding CCCTC-binding factor (CTCF) in familial non-BRCA1/BRCA2 breast cancer." 08/01/2003 - "Concordant with the antiproliferative effects of the CTCF protein in vivo, CTCF may be involved in tumour initiation or proliferation in individual cases of invasive ductal breast carcinoma." 08/01/2003 - "We examined CTCF protein expression in 18 invasive ductal breast carcinomas using immunohistochemistry. " 08/01/2013 - "We previously reported the association of elevated levels of the multifunctional transcription factor, CCCTC binding factor (CTCF), in breast cancer cells with the specific anti-apoptotic function of CTCF. "
4.	Asthma (Bronchial Asthma) 01/01/2022 - "Studies have shown that the expression of CCCTC-binding factor (CTCF) is significantly upregulated in the airway epithelial cells of asthmatic patients, suggesting that CTCF may play an important role in the progression of asthma. " 01/01/2022 - "Long non-coding RNA HOTTIP induces inflammation in asthma by promoting EFNA3 transcription by CCCTC-binding factor."
5.	Atherosclerosis 11/22/2019 - "This study aimed to explore the interactions among long non-coding RNA H19, transcriptional factor CCCTC-binding factor (CTCF) and polycystic kidney disease 1 (PKD1), and to investigate its potentially regulatory effect on vulnerable plaque formation and angiogenesis of atherosclerosis. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	gardenoside
3.	Chromatin
4.	Long Noncoding RNA
5.	Messenger RNA (mRNA)
6.	Sirtuins
7.	Transcription Factors (Transcription Factor)
8.	Cohesins
9.	DNA (Deoxyribonucleic Acid)
10.	Histones (Histone)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)