X-ray Repair Cross Complementing Protein 1

A poly(ADP)-ribose-binding protein that functions in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing radiation. It interacts with DNA LIGASE III and POLY ADP RIBOSE POLYMERASE in BASE EXCISION REPAIR, and may also function in DNA processing and chromosome recombination in GERM CELLS.

Also Known As:

Networked: 57 relevant articles (1 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Wilson, David M: 3 articles (07/2015 - 07/2007)
2.	Zhang, Zhengdong: 2 articles (10/2017 - 03/2013)
3.	Mistry, Kinnari N: 2 articles (01/2016 - 01/2016)
4.	Singh, Preety Kadian: 2 articles (01/2016 - 01/2016)
5.	Bohr, Vilhelm A: 2 articles (07/2015 - 08/2010)
6.	Ladiges, Warren C: 2 articles (01/2015 - 01/2012)
7.	Morton, John: 2 articles (01/2015 - 01/2012)
8.	Pettan-Brewer, Christina: 2 articles (01/2015 - 01/2012)
9.	Chan, Stephen: 2 articles (12/2014 - 06/2013)
10.	Madhusudan, Srinivasan: 2 articles (12/2014 - 06/2013)

Related Diseases

1.	Stomach Neoplasms (Stomach Cancer) 06/01/2016 - "Immunohistochemistry (IHC) was used to evaluate XRCC1 protein expression profiles on surgical specimens of 612 gastric cancer patients. " 05/15/2012 - "JWA and XRCC1 protein levels were significantly downregulated in gastric cancer lesions compared with adjacent noncancerous tissues. " 01/01/2015 - "The aim of the present study was to evaluate the clinical outcome of excision repair cross-complementing protein 1 (ERCC1) and X-ray repair cross-complementing protein 1 (XRCC1) gene polymorphisms in 89 patients receiving oxaliplatin/5-fluorouracil-based chemotherapy as a first-line treatment regimen for advanced gastric cancer. "
2.	Nasopharyngeal Carcinoma 08/01/2018 - "Many studies have investigated polymorphisms of X-ray repair cross-complementing protein 1 (XRCC1) and risk of nasopharyngeal carcinoma (NPC), but the results are somewhat contradictory in different studies. " 01/01/2011 - "Previous studies on the association between X-ray repair cross-complementing protein 1 (XRCC1) polymorphisms and nasopharyngeal carcinoma (NPC) risk showed inconsistent results. "
3.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/01/2011 - "p53 and XRCC1 protein expression were evaluated in 54 samples of nonsmall cell lung cancer. " 01/01/2011 - "No statistically significant correlation was found between histopathological type, grade or early stage (IA, IB) of non-small cell lung cancer and expression of XRCC1 protein profile without neoadjuvant therapy. " 01/01/2011 - "Prognostic significance of p53 protein and X-ray repair cross-complementing protein 1 in non-small cell lung cancer." 11/01/2010 - "The current study investigated whether single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing protein 1 (XRCC1) gene are associated with survival in non-small-cell lung cancer (NSCLC) patients treated with platinum-based chemotherapy. " 12/01/2015 - "Resveratrol Enhances Etoposide-Induced Cytotoxicity through Down-Regulating ERK1/2 and AKT-Mediated X-ray Repair Cross-Complement Group 1 (XRCC1) Protein Expression in Human Non-Small-Cell Lung Cancer Cells."
4.	Squamous Cell Carcinoma of Head and Neck 04/01/2020 - "This study suggests that HNSCC patients with Gln substitution in place of Arg at position 399 (both homozygous and heterozygous) in XRCC1 protein have significantly inferior survival functions, higher recurrence rate, and events after radical treatment." 10/15/2011 - "In HNSCC, high XRCC1 protein expression is associated with poorer survival, particularly in patients receiving chemoradiation. " 10/15/2011 - "XRCC1 protein expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples in 138 consecutive HNSCC patients treated with surgery (n = 31), radiation (15), surgery and radiation (23), surgery and adjuvant chemoradiation (17), primary chemoradiation (51), and palliative measures (1). " 10/15/2011 - "We evaluated X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1) protein in head and neck squamous cell carcinoma (HNSCC) patients in association with outcome. " 10/15/2011 - "High XRCC1 protein expression is associated with poorer survival in patients with head and neck squamous cell carcinoma."
5.	Cataract (Cataracts) 01/01/2015 - "Various combinations of the keywords and MeSH terms were used to screen for potentially relevant studies, specifically "genetic polymorphisms" or "SNPs" or "variation" or "single nucleotide polymorphism" or "polymorphism" or "mutation" or "variant"; "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "X-ray repair cross complementing protein 1" or "Xeroderma Pigmentosum Group D Protein" or "XPD" or "Xeroderma Pigmentosum Complementation Group D Protein" or "ERCC2" or "XRCC1" or "XRCC1 DNA repair protein"; and "Cataract" or " Membranous Cataract" or " Pseudoaphakia." Meta-analyses were conducted using Stata 12.0 software. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Fluorouracil (Carac)
3.	Oxaliplatin (Eloxatin)
4.	X-ray Repair Cross Complementing Protein 1
5.	Platinum
6.	Xeroderma Pigmentosum Group D Protein
7.	DNA (Deoxyribonucleic Acid)
8.	Amino Acids
9.	Ligases (Synthetase)
10.	Endonucleases

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Neoadjuvant Therapy