Drug Misuse

Use of a drug for a purpose not consistent with legal or medical guidelines.

Also Known As:

Non-Prescription Drug Misuse; Non-Prescription Medicine Misuse; Nonprescription Drug Misuse; Over-the-Counter Drug Misuse; Drug Misuse, Non-Prescription; Drug Misuse, Nonprescription; Drug Misuse, Over-the-Counter; Drug Misuses; Drug Misuses, Nonprescription; Drug Misuses, Over-the-Counter; Medicine Misuse, Non-Prescription; Misuse, Drug; Misuse, Non-Prescription Drug; Misuse, Non-Prescription Medicine; Misuse, Nonprescription Drug; Misuse, Over-the-Counter Drug; Misuses, Nonprescription Drug; Misuses, Over-the-Counter Drug; Non Prescription Drug Misuse; Non Prescription Medicine Misuse; Nonprescription Drug Misuses; Over the Counter Drug Misuse; Over-the-Counter Drug Misuses

Networked: 235 relevant articles (11 outcomes, 21 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chronic Pain
2.	Pain (Aches)
3.	Abdominal Pain (Pain, Abdominal)
4.	Constipation
5.	Substance-Related Disorders (Drug Abuse)

Experts

1.	Baird, Janette R: 4 articles (12/2017 - 07/2014)
2.	Liu, Tao: 4 articles (12/2017 - 07/2014)
3.	Merchant, Roland C: 4 articles (12/2017 - 07/2014)
4.	Marsden, John: 4 articles (08/2017 - 03/2002)
5.	Manchikanti, Laxmaiah: 4 articles (03/2014 - 03/2008)
6.	Schifano, Fabrizio: 3 articles (05/2022 - 10/2012)
7.	Sussman, Steve: 3 articles (01/2019 - 01/2004)
8.	Gossop, Michael: 3 articles (11/2006 - 03/2002)
9.	Stewart, Duncan: 3 articles (11/2006 - 03/2002)
10.	Chiappini, Stefania: 2 articles (05/2022 - 02/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Drug Misuse:

1.	Opioid Analgesics (Opioids)IBA 02/23/2022 - "This trial will expand upon previous research advancing the scientific evidence regarding prevention of opioid and other drug misuse during the critical developmental period of late adolescent transition to young adulthood among a sample of American Indian and other youth living within the Cherokee Nation reservation. " 12/01/2023 - "The SMDC was created by linking electronic health record (EHR) data from adult cases of substance (alcohol, opioid, nonopioid drug) misuse at the University of Wisconsin hospitals to socioeconomic and state agency data. " 10/01/2023 - "Results indicate that males are significantly more vulnerable than females to overdose deaths caused by opioid and stimulant drugs, taking into account differing state-level environmental conditions and drug misuse levels. " 03/06/2023 - "Overdose mortality rates for opioids or stimulants are higher in males than females, controlling for rates of drug misuse: State-level data." 02/23/2022 - "Our goal is to implement and evaluate a theory-based, integrated multi-level community intervention designed to prevent the onset and escalation of opioid and other drug misuse. "
2.	Buprenorphine (Subutex)FDA LinkGeneric 09/01/1998 - "If the number of deaths linked to such drug misuse proves high, it may be necessary to review how buprenorphine is dispensed." 09/01/1992 - "Across that interval, beginning to use buprenorphine and temazepam were predictable by prior extent of other substance use, especially cannabis and tobacco, and by the Drug Misuse Scale, using selected MMPI items. " 01/01/2000 - "Buprenorphine and carbamazepine as a treatment for detoxification of opiate addicts with multiple drug misuse: a pilot study." 07/01/2013 - "Medicinal opioids, especially the opioid substitution treatment drugs buprenorphine and methadone, comprised the majority of the findings of both admitted and unexpected drug misuse. " 01/01/2000 - "The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects."
3.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/01/2021 - "This study shows that drug misuse/abuse in soccer is a real matter of debate, especially with regards to NSAIDs, exposing athletes to predictable and/or unpredictable risks for their health." 04/15/2016 - "While NSAIDs might be effective for the short term and opioids might help with urgent pain relief and improving the life quality, their long-term use is associated with significant side effects and drug misuse or abuse. " 09/01/2019 - "We focused on specifically identified situations of drug misuse involving non-steroidal anti-inflammatory drugs (NSAIDs), antiemetics in patients with Parkinson's disease and antipsychotics in pediatrics; we also focused on direct anticoagulants, asthma and oral antidiabetic drugs but results for these latter are only shown in supplementary materials. "
4.	Oxazepam (Serax)FDA LinkGeneric 01/01/2000 - "The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects."
5.	Carbamazepine (Tegretol)FDA LinkGeneric 01/01/2000 - "Buprenorphine and carbamazepine as a treatment for detoxification of opiate addicts with multiple drug misuse: a pilot study." 01/01/2000 - "The present study supports the hypothesis that buprenorphine/carbamazepine is more effective than oxazepam/carbamazepine in rapid opioid detoxification in patients with additional multiple drug misuse and both regimens were safe with no unexpected side effects."
6.	spleen fibrinolytic proteinase (human) (SFP)IBA 04/01/2003 - "One study also highlighted the potential value of culturally focused skills training over the longer-term (NNT = 17 over 3.5 years for 4+ drinks in the last week) (1) Research into important outcome variables needs to be undertaken; (2) the methodology of evaluations needs to be improved; (3) the SFP needs to be evaluated on a larger scale and in different settings; (4) culturally focused interventions require further development and rigorous evaluation; and (5) an international register of alcohol and drug misuse prevention interventions should be established and criteria agreed for rating prevention interventions in terms of safety, efficacy and effectiveness."
7.	Heroin (Diamorphine)IBA 01/01/2023 - "SGM by everyday discrimination interactions was significant for alcohol misuse, over-the-counter drug misuse, and heroin use, with the association between everyday discrimination and substance misuse stronger among gender minorities. " 10/01/2019 - "Label preferences by individuals who use heroin and are in early recovery are consistent with general guidelines about use of first-person language and suggest avoidance of language indicative of drug misuse or dependence." 07/05/2011 - "In light of these and previous results, we recommend hair analysis in babies and children from risky environments to detect exposure to heroin and other drug misuse, which could provide the basis for specific social and health interventions." 01/01/2007 - "The purpose of this article is to characterize fully employed users of heroin, compare them with their unemployed counterparts, and identify demographic, human, and social capital and drug misuse factors that are differentially associated with full employment. " 01/01/2001 - "Intravenous drug misuse, principally heroin, occurs primarily in the Greater Dublin area. "
8.	Cocaine (Cocaine HCl)IBA 03/01/2009 - "All of the cases of drug misuse involved cocaine. " 05/01/2000 - "First, a postal survey of all known drug misuse treatment services ascertained approximate numbers of cocaine misusers presenting and receiving a specified range of treatments. " 03/01/1996 - "Results showed that the likelihood of admitting cocaine use was positively related to having received drug misuse treatment before, and negatively related to being Hispanic. " 06/01/2001 - "Marked differences were found between users recruited at these sites, especially in relation to age, gender, employment status, criminal history, history of prostitution, previous drug misuse treatment, duration of cocaine use and lifetime use of intravenous cocaine. " 06/01/2015 - "Despite the patient's denial of recent cocaine use, this positive cocaine screening result in conjunction with a remote history of drug misuse impacted the patient's recommended pain therapy. "
9.	AminesIBA 04/01/1996 - "Phenethylamine, a putrefactive amine, gave positive results for AMP at concentrations over 5,000 ng/mL. The method was applied to 9 hemolyzed blood samples and 3 turbid urine samples from 12 forensic autopsy cases suspected of drug misuse. "
10.	Adenosine Monophosphate (AMP)IBA 04/01/1996 - "Phenethylamine, a putrefactive amine, gave positive results for AMP at concentrations over 5,000 ng/mL. The method was applied to 9 hemolyzed blood samples and 3 turbid urine samples from 12 forensic autopsy cases suspected of drug misuse. "

Therapies and Procedures

1.	Therapeutics 05/22/2023 - "The increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. " 01/01/2019 - "Recent studies of mixed quality focus on advocacy and empowerment, integrated interventions (with alcohol and drug misuse) and couples counselling for domestic violence and cognitive behavioural or processing therapy for sexual violence. " 09/01/2014 - "All guidelines espouse an individual approach to management, beginning with a comprehensive patient evaluation, with particular focus on eliciting factors that may indicate potential drug misuse and abuse, and a trial of therapy to determine the course of treatment. " 01/01/2020 - "The vulnerable group included participants in one or more of these categories: 65 years of age or older, nonwhite, no insurance or Medicaid insurance, preinjury receipt of psychological therapy or counseling, preinjury alcohol and/or drug misuse, or with a preexisting disability. " 01/01/2019 - "Multiple functional variations in the neural processing networks supporting preference for immediate and future rewards signal individual differences in readiness to benefit from an effective behavioral therapy for reducing adolescent drug misuse. "
2.	Polypharmacy 02/01/1992 - "The authors are confident, however, that drug misuse and polypharmacy can be reduced in older persons by the use of current knowledge of risk factors associated with polypharmacy and by improved communication between the physician and patient." 04/01/1992 - "Polypharmacy and drug misuse were common among the sample. " 02/01/1992 - "Methods to prevent polypharmacy and drug misuse have not been well studied. " 02/01/1992 - "Overcoming problems with polypharmacy and drug misuse in the elderly." 02/01/1992 - "Sound data suggest that polypharmacy and drug misuse are highly prevalent in long-term care facilities. "
3.	Self Administration (Administration, Self) 11/13/2008 - "At present, passive vaccination has recognized efficacy in treating certain gross symptoms of drug misuse, namely, motor activation, self-administration, and overdose. "
4.	Condoms (Condom) 09/01/2011 - "Psychosocial pathways to inconsistent condom use among male sex workers: personality, drug misuse and criminality." 01/01/2022 - "This study aimed to build on central tenets of objectification theory through its examination of sexist experiences in relation to body surveillance, body shame, depressive symptoms, and the health risk behaviors of substance use (i.e., alcohol and drug misuse) and sexual risk (i.e., condom use and number of sexual partners) among a large sample of college student women. "
5.	Drug Prescriptions 03/11/2020 - "Deprescribing of these medications could decrease both drug misuse and cost of drug prescription. " 10/04/2013 - "This study investigated and quantified risk factors of dose escalation, as an indication of drug misuse and dependency of benzodiazepines and congeners, among presumably drug naïve patients in the Norwegian drug prescription database, observed over 3 years. "